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Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Authors: Markella Konstantinidou, Marios Zingiridis, Marloes A M Pennings, Michael Fragkiadakis, Johanna M Virta, Jezrael L Revalde, Emira J Visser, Christian Ottmann, Luc Brunsveld, Constantinos G Neochoritis, Michelle R Arkin

Journal: Nature Communications

PubMed ID: 40659654

Doi: 10.1038/s41467-025-61176-4

Products & Services: Peptide Synthesis

Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC)

Authors: Raghuvir Viswanatha, Samuel Entwisle, Yanhui Hu, Ah-Ram Kim, Kelly Reap, Matthew Butnaru, Mujeeb Qadiri, Stephanie E Mohr, Norbert Perrimon

Journal: Nature Communications

PubMed ID: 40659672

Doi: 10.1038/s41467-025-61692-3

Products & Services: Custom Vector Construction

Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology

Authors: De Xing, Tao Bai, Ozlem Neyisci, Seyedeh Zahra Paylakhi, Alexander J Duval, Yasemin Tekin, Mazhar Adli

Journal: Nature Communications

PubMed ID: 40681502

Doi: 10.1038/s41467-025-61848-1

Products & Services: Gene Synthesis

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Authors: Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S Yarla, Lu Wang, Jindan Yu, Jonathan C Zhao, Ivet Bahar, Yong Wan

Journal: Advanced Science

PubMed ID: 40671262

Doi: 10.1002/advs.202415585

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Non-antibiotics disrupt colonization resistance against enteropathogens

Authors: Anne Grießhammer, Jacobo de la Cuesta-Zuluaga, Patrick Müller, Cordula Gekeler, Jan Homolak, Hsuan Chang, Katharina Schmitt, Chiara Planker, Verena Schmidtchen, Suchira Gallage, Erwin Bohn, Taylor H Nguyen, Jenny Hetzer, Mathias Heikenwälder, Kerwyn Casey Huang, Taiyeb Zahir, Lisa Maier

Journal: Nature

PubMed ID: 40670795

Doi: 10.1038/s41586-025-09217-2

Products & Services: Gene Synthesis

Natural variation of an E3 ubiquitin ligase encoding gene Chalk9 regulates grain chalkiness in rice

Authors: Zhi Hu, Hongchun Liu, Min Guo, Xiang Han, Youguang Li, Rujia Chen, Yifan Guo, Yihao Yang, Shengyuan Sun, Yong Zhou, Minghong Gu, Changjie Yan

Journal: Nature Communications

PubMed ID: 40683885

Doi: 10.1038/s41467-025-61683-4

Products & Services: Polyclonal Antibody Services

CRISPRi screen identifies FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa

Authors: Yu Zhang, Tingting Zhang, Xue Xiao, Yejun Wang, Adam Kawalek, Jinzhao Ou, Anmin Ren, Wenhao Sun, Vincent de Bakker, Yujie Liu, Yuelong Li, Liang Yang, Liang Ye, Ning Jia, Jan-Willem Veening, Xue Liu

Journal: Nature Communications

PubMed ID: 40595632

Doi: 10.1038/s41467-025-61208-z

Products & Services: Oligo pool

DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation

Authors: Rui Zhang, Xin Zhang, Hua Bai, Qiuyu Cheng, Xia Yao, Shi Li, Vincenzo Torraca, Chaojun Yan, Xueying Dong, Siyi Miao, Xueyuan Hu, Yeping Yu, Yueyan Wu, Hongfei Tan, Xin Chen, Shicheng Liu, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Xing-Zhen Chen, Zhiyin Song, Cefan Zhou, Jingfeng Tang

Journal: Nature Communications

PubMed ID: 40595569

Doi: 10.1038/s41467-025-60887-y

Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation

Authors: Xiaoman Ju, Eva Maria Putz, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong, Biping Deng, Jing Hu, Juming Yan

Journal: Nature Communications

PubMed ID: 40593670

Doi: 10.1038/s41467-025-60922-y.

Products & Services: Custom Vector Construction

Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial

Authors: Mangalakumari Jeyanathan, Sam Afkhami, Michael R D'Agostino, Imran Satia, Dominik K Fritz, Kate Miyasaki, Jann C Ang, Anna Zganiacz, Karen J Howie, Marilyn Swinton, Emilio Aguirre, Michael B Zheng, Natallia Kazhdan, Anna Dvorkin-Gheva, Lawrence Mbuagbaw, Maria Fe C Medina, Nermin Diab, Danica L Brister, Gail M Gauvreau, Brian D Lichty, Matthew S Miller, Fiona Smaill, Zhou Xing

Journal: Nature Communications

PubMed ID: 40603330

Doi: 10.1038/s41467-025-60726-0

Products & Services: Codon Optimization