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A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis

Authors: Caroline De Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D'Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo M Moreira, Nicoletta Basilico, David L Williams, Miguel Prudêncio, Bruno Pradines, Maribel Navarro

Journal: Pharmaceutics

PubMed ID: 35745823

Doi: 10.3390/pharmaceutics14061251

Products & Services: Mammalian Expression

Engineering a highly sensitive biosensor for abscisic acid in mammalian cells

Authors: Seo Woo Kim, Kübra Alci, Femke Van Gaever, Yasmine Driege, Keylla Bicalho, Geert Goeminne, Claude Libert, Alain Goossens, Rudi Beyaert, Jens Staal

Journal: FEBS Lett

PubMed ID: 35727199

Doi: 10.1002/1873-3468.14431

Products & Services: Custom Vector Construction

Mapping the deformability of natural and designed cellulosomes in solution

Authors: Jonathan Dorival, Sarah Moraïs, Aurore Labourel, Bartosz Rozycki, Pierre-Andre Cazade, Jérôme Dabin, Eva Setter-Lamed, Itzhak Mizrahi, Damien Thompson, Aurélien Thureau, Edward A Bayer, Mirjam Czjzek

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 35725490

Doi: 10.1186/s13068-022-02165-3

Products & Services: Plasmid DNA Preparation

The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication

Authors: Lucca R Policastro, Isabela Dolci, Andre S Godoy, José V J Silva Júnior, Uriel E A Ruiz, Igor A Santos, Ana C G Jardim, Kirandeep Samby, Jeremy N Burrows, Timothy N C Wells, Laura H V G Gil, Glaucius Oliva, Rafaela S Fernandes

Journal: Viruses

PubMed ID: 35891332

Doi: 10.3390/v14071351

Products & Services: Gene Synthesis

Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system

Authors: Xiaoxiao Han, Jiacheng Xu, Zixin Chen, Ping Li, Lili Zhao, Jincheng Tao, Yu Shen, Shengze Zhu, Bin Yu, Jianwei Zhu, Qianqian Cao, Songlin Zhou

Journal: Exp Neurol

PubMed ID: 35779613

Doi: 10.1016/j.expneurol.2022.114157

Products & Services: Gene Synthesis

Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4

Authors: Hugh C Welles, Hannah A D King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A Schramm, Nicole A Doria-Rose, Adrienne E Swanstrom, James A Hoxie, Celia LaBranche, David C Montefiori, Daniel C Douek, Peter D Kwong, John R Mascola, Mario Roederer, Rosemarie D Mason

Journal: PLoS Pathog

PubMed ID: 35709309

Doi: 10.1371/journal.ppat.1010574

Products & Services: DNA Sequencing

ISCA2 deficiency leads to heme synthesis defects and impaired erythroid differentiation in K562 cells by indirect ROS-mediated IRP1 activation

Authors: Jing Wang, Mengyao Jiang, Guanru Yue, Lifei Zhu, Xueqing Wang, Mengxiang Liang, Xiaolin Wu, Beibei Li, Yilin Pang, Guoqiang Tan, Jianghui Li

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 35714932

Doi: 10.1016/j.bbamcr.2022.119307

Products & Services: Custom Vector Construction

A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection

Authors: Tsai-Teng Tzeng, Kit Man Chai, Kuan-Yin Shen, Chia-Yi Yu, Shiu-Ju Yang, Wan-Chun Huang, Hung-Chun Liao, Fang-Feng Chiu, Horng-Yunn Dou, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu

Journal: npj Vaccines

PubMed ID: 35662254

Doi: 10.1038/s41541-022-00482-0

Products & Services: Mammalian Expression

Serological screening in wild ruminants in Germany, 2021/2022: No evidence of SARS-CoV-2, bluetongue virus or pestivirus spread but high seroprevalences against Schmallenberg virus

Authors: Kerstin Wernike, Luisa Fischer, Mark Holsteg, Andrea Aebischer, Anja Petrov, Katharina Marquart, Ulrich Schotte, Jacob Schön, Donata Hoffmann, Silke Hechinger, Antonie Neubauer-Juric, Julia Blicke, Thomas C Mettenleiter, Martin Beer

Journal: Transbound Emerg Dis

PubMed ID: 35585653

Doi: 10.1111/tbed.14600

Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum

Authors: Júlio Souza Dos-Santos, Luan Firmino-Cruz, Alessandra Marcia da Fonseca-Martins, Diogo Oliveira-Maciel, Gustavo Guadagnini Perez, Victor A Roncaglia-Pereira, Carlos H Dumard, Francisca H Guedes-da-Silva, Ana C Vicente Santos, Monique Dos Santos Leandro, Jesuino Rafael Machado Ferreira, Kamila Guimarães-Pinto, Luciana Conde, Danielle A S Rodrigues, Marcus Vinicius de Mattos Silva, Renata G F Alvim, Tulio M Lima, Federico F Marsili, Daniel P B Abreu, Orlando C Ferreira, Ronaldo da Silva Mohana Borges, Amilcar Tanuri, Thiago Moreno L Souza, Bartira Rossi-Bergmann, André M Vale, Jerson Lima Silva, Andréa Cheble de Oliveira, Alessandra D'Almeida Filardy, Andre M O Gomes, Herbert Leonel de Matos Guedes

Journal: Front Immunol

PubMed ID: 35844561

Doi: 10.3389/fimmu.2022.884760

Products & Services: PCR Cloning and Subcloning