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A single main-chain hydrogen bond required to keep GABAA receptors closed

Authors: Cecilia M Borghese, Jason D Galpin, Samuel Eriksson Lidbrink, Yuxuan Zhuang, Netrang G Desai, Rebecca J Howard, Erik Lindahl, Christopher A Ahern, Marcel P Goldschen-Ohm

Journal: Nature Communications

PubMed ID: 40603861

Doi: 10.1038/s41467-025-61447-0

Products & Services: Mutagenesis Services

Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses

Authors: Arne Matthys, Jan Felix, Joao Paulo Portela Catani, Kenny Roose, Wim Nerinckx, Benthe Van Buyten, Daria Fijalkowska, Nico Callewaert, Savvas N Savvides, Xavier Saelens

Journal: Nature Communications

PubMed ID: 40593518

Doi: 10.1038/s41467-025-60232-3

Products & Services: Catalog Antibodies

Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery

Authors: Amanda X Y Chen, Kah Min Yap, Joelle S Kim, Kevin Sek, Yu-Kuan Huang, Phoebe A Dunbar, Volker Wiebking, Jesse D Armitage, Isabelle Munoz, Kirsten L Todd, Emily B Derrick, Dat Nguyen, Junming Tong, Cheok Weng Chan, Thang X Hoang, Katherine M Audsley, Marit J van Elsas, Jim Middelburg, Joel N Lee, Maria N de Menezes, Thomas J Cole, Jasmine Li, Christina Scheffler, Andrew M Scott, Laura K Mackay, Jason Waithman, Jane Oliaro, Simon J Harrison, Ian A Parish, Junyun Lai, Matthew H Porteus, Imran G House, Phillip K Darcy, Paul A Beavis

Journal: Nature

PubMed ID: 40604285

Doi: 10.1038/s41586-025-09212-7

Products & Services: PCR Cloning and Subcloning

Molecular architecture and catalytic mechanism of human glycogen debranching enzyme

Authors: Huiyi Guan, Huan Chen, He Geng, Ruifang Ma, Zhongmin Liu, Yong Wang, Yifang Chen, Kaige Yan

Journal: Nature Communications

PubMed ID: 40593796

Doi: 10.1038/s41467-025-61077-6

Products & Services: Protein and Antibody Isolation

Visualization of a multi-turnover Cas9 after product release

Authors: Kaitlyn A. Kiernan & David W. Taylor

Journal: Nature Communications

PubMed ID: 40593576

Doi: 10.1038/s41467-025-60668-7

Products & Services: Synthetic Guide RNA

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ

Authors: K S Beckwith, Ø Ødegård-Fougner, N R Morero, C Barton, F Schueder, W Tang, S Alexander, J-M Peters, R Jungmann, E Birney, J Ellenberg

Journal: Nature Communications

PubMed ID: 40683887

Doi: 10.1038/s41467-025-61689-y

Products & Services: Oligo pool

Rationally Designed TadA-Derived Cytosine Editors Enable Context-Independent Zebrafish Genome Editing

Authors: Wei Qin, Sheng-Jia Lin, Yu Zhang, Kevin Huang, Cassidy Petree, Kevin Boyd, Pratishtha Varshney, Gaurav K Varshney

Journal: Advanced Science

PubMed ID: 40685751

Doi: 10.1002/advs.202509800

Products & Services: Codon Optimization

Structural insights into the roles of PARP4 and NAD+ binding in the human vault cage

Authors: Jane E Lodwick, Rong Shen, Satchal Erramilli, Yuan Xie, Karolina Roganowicz, Simone Ritchey, Anthony A Kossiakoff, Minglei Zhao

Journal: Nature Communications

PubMed ID: 40691181

Doi: 10.1038/s41467-025-61981-x

Products & Services: Insect Expression

Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination

Authors: Jaigeeth Deveryshetty, Ayush Mistry, Sushil Pangeni, Mohamed Ghoneim, Monica Tokmina-Lukaszewska, Steven K Gore, Jie Liu, Vikas Kaushik, Simrithaa Karunakaran, Angela Taddei, Wolf-Dietrich Heyer, Taekjip Ha, Brian Bothner, Edwin Antony

Journal: Nature Communications

PubMed ID: 40691144

Doi: 10.1038/s41467-025-61811-0

Products & Services: Codon Optimization

Human Schlafen 14 Cleavage of Short Double-Stranded RNAs Underpins its Antiviral Activity

Authors: Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui

Journal: Advanced Science

PubMed ID: 40642785

Doi: 10.1002/advs.202501727

Products & Services: Gene Synthesis