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Targeted DNA integration in human cells without double-strand breaks using CRISPR RNA-guided transposases

Authors: George D Lampe, Rebeca T King, Tyler S Halpin-Healy, Sanne E Klompe, Marcus I Hogan, Phuc Leo H Vo, Stephen Tang, Alejandro Chavez, Samuel H Sternberg

Journal: biorxiv

PubMed ID: 36993517

Doi: 10.1101/2023.03.17.533036

Products & Services: Molecular Biology Reagents

KRT5 mutation regulate melanin metabolism through notch signalling pathway between keratinocytes and melanocytes

Authors: Weixue Jia, Yuanyuan Zhang, Xue Wang, Lingling Luo, Heng Sun, Yiqun Jiang, Jianbo Wang, Qiuxia Mao, Youming Guo, Lingzhuo Kong, Ran Mo, Chengrang Li

Journal: Exp Dermatol

PubMed ID: 36809573

Doi: 10.1111/exd.14761

Products & Services: Molecular Biology Reagents

Immunoglobulin G subclasses confer protection against bloodstream dissemination through distinct mechanisms in mouse models

Authors: Xinhai Chen, Haley Gula, Tonu Pius, Chong Ou, Margaryta Gomozkova, Lai-Xi Wang, Olaf Schneewind, Dominique Missiakas

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36972444

Doi: 10.1073/pnas.2220765120

Products & Services: Protein and Antibody Isolation

High-force catch bonds between the Staphylococcus aureus surface protein SdrE and complement regulator factor H drive immune evasion

Authors: Telmo O Paiva, Joan A Geoghegan, Yves F Dufrêne

Journal: Commun Biol

PubMed ID: 36944849

Doi: 10.1038/s42003-023-04660-1

Products & Services: Peptide Synthesis

Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrin β to manipulate inflammatory responses

Authors: Yuanlong Guo, Yong Ao, Chen Ye, Ruidi Xia, Jiaomei Mi, Zhengjie Shan, Mengru Shi, Lv Xie, Zetao Chen

Journal: Nano Res

PubMed ID: 37359074

Doi: 10.1007/s12274-023-5550-0

Products & Services: Protein and Antibody Isolation

Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression

Authors: Yu Sun, Wenjun Xiao, Yang Yu, Yuchen Jiang, Zhijie Xiao, Defa Huang, Tianyu Zhong, Jiang Li, Xi Xiang, Yulong He, Zhigang Li

Journal: Exp Cell Res

PubMed ID: 36958650

Doi: 10.1016/j.yexcr.2023.113565

Products & Services: Gene Synthesis

Development of an efficient method for selection of stable cell pools for protein expression and surface display with Expi293F cells

Authors: Chuan Chen, Zening Wang, Zehua Sun, Wei Li, Dimiter S Dimitrov

Journal: Cell Biochem Funct

PubMed ID: 36864545

Doi: 10.1002/cbf.3787

Products & Services: Recombinant Proteins

Uman-type neurofilament light antibodies are effective reagents for the imaging of neurodegeneration

Authors: Gerry Shaw, Irina Madorsky, Ying Li, YongSheng Wang, Marda Jorgensen, Sabhya Rana, David D Fuller

Journal: Brain Commun

PubMed ID: 37091583

Doi: 10.1093/braincomms/fcad067

Products & Services: Protein and Antibody Isolation

Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective

Authors: Przemyslaw Grygier, Katarzyna Pustelny, Jakub Nowak, Przemyslaw Golik, Grzegorz M Popowicz, Oliver Plettenburg, Grzegorz Dubin, Filipe Menezes, Anna Czarna

Journal: J Med Chem

PubMed ID: 36883902

Doi: 10.1021/acs.jmedchem.2c01887

Products & Services: Combinatorial Mutant library

JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension

Authors: Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao

Journal: Cell Death Discov

PubMed ID: 36934091

Doi: 10.1038/s41420-023-01390-5

Products & Services: Catalog Peptides