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Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery

Authors: Amanda X Y Chen, Kah Min Yap, Joelle S Kim, Kevin Sek, Yu-Kuan Huang, Phoebe A Dunbar, Volker Wiebking, Jesse D Armitage, Isabelle Munoz, Kirsten L Todd, Emily B Derrick, Dat Nguyen, Junming Tong, Cheok Weng Chan, Thang X Hoang, Katherine M Audsley, Marit J van Elsas, Jim Middelburg, Joel N Lee, Maria N de Menezes, Thomas J Cole, Jasmine Li, Christina Scheffler, Andrew M Scott, Laura K Mackay, Jason Waithman, Jane Oliaro, Simon J Harrison, Ian A Parish, Junyun Lai, Matthew H Porteus, Imran G House, Phillip K Darcy, Paul A Beavis

Journal: Nature

PubMed ID: 40604285

Doi: 10.1038/s41586-025-09212-7

Products & Services: PCR Cloning and Subcloning

Molecular architecture and catalytic mechanism of human glycogen debranching enzyme

Authors: Huiyi Guan, Huan Chen, He Geng, Ruifang Ma, Zhongmin Liu, Yong Wang, Yifang Chen, Kaige Yan

Journal: Nature Communications

PubMed ID: 40593796

Doi: 10.1038/s41467-025-61077-6

Products & Services: Protein and Antibody Isolation

Visualization of a multi-turnover Cas9 after product release

Authors: Kaitlyn A. Kiernan & David W. Taylor

Journal: Nature Communications

PubMed ID: 40593576

Doi: 10.1038/s41467-025-60668-7

Products & Services: Synthetic Guide RNA

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ

Authors: K S Beckwith, Ø Ødegård-Fougner, N R Morero, C Barton, F Schueder, W Tang, S Alexander, J-M Peters, R Jungmann, E Birney, J Ellenberg

Journal: Nature Communications

PubMed ID: 40683887

Doi: 10.1038/s41467-025-61689-y

Products & Services: Oligo pool

Rationally Designed TadA-Derived Cytosine Editors Enable Context-Independent Zebrafish Genome Editing

Authors: Wei Qin, Sheng-Jia Lin, Yu Zhang, Kevin Huang, Cassidy Petree, Kevin Boyd, Pratishtha Varshney, Gaurav K Varshney

Journal: Advanced Science

PubMed ID: 40685751

Doi: 10.1002/advs.202509800

Products & Services: Codon Optimization

Structural insights into the roles of PARP4 and NAD+ binding in the human vault cage

Authors: Jane E Lodwick, Rong Shen, Satchal Erramilli, Yuan Xie, Karolina Roganowicz, Simone Ritchey, Anthony A Kossiakoff, Minglei Zhao

Journal: Nature Communications

PubMed ID: 40691181

Doi: 10.1038/s41467-025-61981-x

Products & Services: Insect Expression

Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination

Authors: Jaigeeth Deveryshetty, Ayush Mistry, Sushil Pangeni, Mohamed Ghoneim, Monica Tokmina-Lukaszewska, Steven K Gore, Jie Liu, Vikas Kaushik, Simrithaa Karunakaran, Angela Taddei, Wolf-Dietrich Heyer, Taekjip Ha, Brian Bothner, Edwin Antony

Journal: Nature Communications

PubMed ID: 40691144

Doi: 10.1038/s41467-025-61811-0

Products & Services: Codon Optimization

Human Schlafen 14 Cleavage of Short Double-Stranded RNAs Underpins its Antiviral Activity

Authors: Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui

Journal: Advanced Science

PubMed ID: 40642785

Doi: 10.1002/advs.202501727

Products & Services: Gene Synthesis

Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury

Authors: Zhiqiang Zhao, Xinzhu Shan, Jing Ding, Bin Ma, Buyao Li, Wendi Huang, Qingqing Yang, Yian Fang, Junhe Chen, Chenglin Song, Chenlong Wei, Shuai Liu, Xingdi Cheng, Shengran Zhang, Yunxuan Liu, Hongkun Wu, Cong Luo, Shaokun Shu, Xue Qiao, Zefeng Wang, Xueguang Lu, Lei Miao

Journal: Nature Communications

PubMed ID: 40659631

Doi: 10.1038/s41467-025-61688-z

Products & Services: Plasmid DNA Preparation

Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice

Authors: Zhiyuan Li, Zheng Tian, Xiaoliu Shi, Aijun Long, Yazhuo Wang, Yan Yang, Yaqi Wang, Jingjing Zhang, Yiguo Wang

Journal: Nature Communications

PubMed ID: 40670400

Doi: 10.1038/s41467-025-61963-z

Products & Services: Protein and Antibody Isolation