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Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents

Authors: Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C Chenna, Drake M Mellott, Zane W Taylor, Vivian Tat, Christopher Z Garcia, Ardala Katzfuss, Chien-Te K Tseng, Thomas D Meek

Journal: Front Chem

PubMed ID: 35860632

Doi: 10.3389/fchem.2022.867928

Products & Services: Gene Synthesis

HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations

Authors: Yong Du, Yongfeng Chen, Yuxia Wang, Jinju Chen, Xiaorong Lu, Li Zhang, Yan Li, Zhaofu Wang, Guozhong Ye, George Zhang

Journal: Mol Cancer Ther

PubMed ID: 35499406

Doi: 10.1158/1535-7163.MCT-21-0835

Products & Services: Protein and Antibody Isolation

Analysis of FR901379 Biosynthetic Genes in by Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Based Genomic Manipulation

Authors: Teng-Yun Wei, Yan Zheng, Miyang Wan, Songbai Yang, Jiawei Tang, Yuanjie Wu, Jiyang Li, Shao-Xin Chen

Journal: ACS Chem Biol

PubMed ID: 35822391

Doi: 10.1021/acschembio.2c00250

Products & Services: Gene Fragments

Interaction of Liberibacter Solanacearum with Host Psyllid Vitellogenin and Its Association with Autophagy

Authors: Poulami Sarkar, Murad Ghanim

Journal: Microbiol Spectr

PubMed ID: 35863005

Doi: 10.1128/spectrum.01577-22

Products & Services: Protein and Antibody Isolation

Ligand-induced transmembrane conformational coupling in monomeric EGFR

Authors: Shwetha Srinivasan, Raju Regmi, Xingcheng Lin, Courtney A Dreyer, Xuyan Chen, Steven D Quinn, Wei He, Matthew A Coleman, Kermit L Carraway, Bin Zhang, Gabriela S Schlau-Cohen

Journal: Nat Commun

PubMed ID: 35794108

Doi: 10.1038/s41467-022-31299-z

Products & Services: Mutagenesis Services

Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis

Authors: Zachary Armstrong, Richard W Meek, Liang Wu, James N Blaza, Gideon J Davies

Journal: Structure

PubMed ID: 35907402

Doi: 10.1016/j.str.2022.07.001

Products & Services: Mutant Libraries

Comprehensive Evaluation and Comparison of Machine Learning Methods in QSAR Modeling of Antioxidant Tripeptides

Authors: Zhenjiao Du, Donghai Wang, Yonghui Li

Journal: ACS Omega

PubMed ID: 35910147

Doi: 10.1021/acsomega.2c03062

Products & Services: Peptide Synthesis

Relaxin Affects Airway Remodeling Genes Expression through Various Signal Pathways Connected with Transcription Factors

Authors: Joanna Wieczfinska, Rafal Pawliczak

Journal: Int J Mol Sci

PubMed ID: 35955554

Doi: 10.3390/ijms23158413

Products & Services: Protein Electrophoresis and Western

Genetic diversity of collaborative cross mice enables identification of novel rift valley fever virus encephalitis model

Authors: Haley N Cartwright, Dominique J Barbeau, Joshua D Doyle, Ed Klein, Mark T Heise, Martin T Ferris, Anita K McElroy

Journal: PLoS Pathog

PubMed ID: 35834486

Doi: 10.1371/journal.ppat.1010649

Products & Services: Polyclonal Antibody Services

Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis

Authors: Wenli Liu, Nataliya Östberg, Mustafa Yalcinkaya, Huijuan Dou, Kaori Endo-Umeda, Yang Tang, Xintong Hou, Tong Xiao, Trevor P Fidler, Sandra Abramowicz, Yong-Guang Yang, Oliver Soehnlein, Alan R Tall, Nan Wang

Journal: J Clin Invest

PubMed ID: 35587375

Doi: 10.1172/JCI155724

Products & Services: Recombinant Proteins