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Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe

Authors: Jinal A Patel, Camryn Zezelic, Julie Rageul, Joanne Saldanha, Arafat Khan, Hyungjin Kim

Journal: Nucleic Acids Research

PubMed ID: 37144518

Doi: 10.1093/nar/gkad363

Products & Services: ORF cDNA Clones/MolecularCloud

Characterization of the conserved features of the NSE6 subunit of the Physcomitrium patens SMC5/6 complex

Authors: Edit Lelkes , Jitka Jemelková , Marcela Holá , Barbora Štefanovie , Peter Kolesár , Radka Vágnerová , Eva Dvořák Tomaštíková , Ales Pecinka , Karel J Angelis , Jan J Paleček

Journal: Plant J .

PubMed ID: 37191775

Doi: 10.1111/tpj.16282

Products & Services: Gene Synthesis

A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex

Authors: Hong-Wei Zhang, Kun Huang, Zhan-Xi Gu, Xiao-Xian Wu, Jia-Wei Wang, Yu Zhang

Journal: Nat Commun .

PubMed ID: 37253723

Doi: 10.1038/s41467-023-38619-x

Products & Services: Protein and Antibody Isolation

13C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme–Substrate Complex of an Active, N-Linked Glycosylated Lipoxygenase

Authors: Ajay Sharma , Chris Whittington , Mohammed Jabed , S Gage Hill , Anastasiia Kostenko , Tao Yu , Pengfei Li , Peter E Doan , Brian M Hoffman , Adam R Offenbacher

Journal: Biochemistry .

PubMed ID: 37115010

Doi: 10.1021/acs.biochem.3c00119

Products & Services: Gene Synthesis

Li-Mg-Si bioceramics provide a dynamic immuno-modulatory and repair-supportive microenvironment for peripheral nerve regeneration

Authors: Yiting Sun , Hongjian Zhang, Yu Zhang , Zheqi Liu , Dongming He , Wanlin Xu 4, Siyi Li , Chenping Zhang , Zhen Zhang

Journal: Bioact Mater.

PubMed ID: 37292230

Doi: 10.1016/j.bioactmat.2023.05.013

Products & Services: Protein and Antibody Isolation

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

Authors: Isha Singh; Anubha Seth; Christian B. Billesb lle; Joao Braz; Ramona M. Rodriguiz; Kasturi Roy; Bethlehem Bekele; Veronica Craik; Xi-Ping Huang; Danila Boytsov; Vladimir M. Pogorelov; Parnian Lak; Henry O Donnell; Walter Sandtner; John J. Irwin; Bryan L. Roth; Allan I. Basbaum; William C. Wetsel; Aashish Manglik; Brian K. Shoichet; Gary Rudnick

Journal: Cell

PubMed ID: 37137306

Doi: 10.1016/j.cell.2023.04.010

PTPMT1 protects cardiomyocytes from necroptosis induced by γ-ray irradiation through alleviating mitochondria injury

Authors: Jing Yi, Liang Yue, Yuning Zhang, Ning Tao, Han Duan, Lin Lv, Yingxia Tan, Hua Wang

Journal: Am J Physiol Cell Physiol

PubMed ID: 37154493

Doi: 10.1152/ajpcell.00466.2022

Products & Services: Codon Optimization

DPY30 Promotes Proliferation and Cell Cycle Progression of Colorectal Cancer Cells via Mediating H3K4 Trimethylation

Authors: Wei-Chao Su, Xiao-Mei Mao, Si-Yang Li, Chun-Ying Luo, Rui Fan, Hai-Feng Jiang, Lin-Jun Zhang, Ya-Tao Wang, Guo-Qiang Su, Dong-Yan Shen

Journal: Int J Med Sci