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Targeted sequencing of cancer-related genes reveals a recurrent TOP2A variant which affects DNA binding and coincides with global transcriptional changes in glioblastoma

Authors: Bartlomiej Gielniewski, Katarzyna Poleszak, Adria-Jaume Roura, Paulina Szadkowska, Karol Jacek, Sylwia K Krol, Rafal Guzik, Paulina Wiechecka, Marta Maleszewska, Beata Kaza, Andrzej Marchel, Tomasz Czernicki, Andrzej Koziarski, Grzegorz Zielinski, Andrzej Styk, Maciej Kawecki, Cezary Szczylik, Ryszard Czepko, Mariusz Banach, Wojciech Kaspera, Wojciech Szopa, Mateusz Bujko, Bartosz Czapski, Miroslaw Zabek, Ewa Iżycka-Świeszewska, Wojciech Kloc, Pawel Nauman, Joanna Cieslewicz, Wieslawa Grajkowska, Natalia Morosini, Houtan Noushmehr, Bartosz Wojtas, Bozena Kaminska

Journal: Int J Cancer

PubMed ID: 37338006

Doi: 10.1002/ijc.34631

Products & Services: Protein and Antibody Isolation

Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection

Authors: Manuela C Aguirre-Botero, Lawrence T Wang, Pauline Formaglio, Eduardo Aliprandini, Jean-Michel Thiberge, Arne Schön, Yevel Flores-Garcia, Shamika Mathis-Torres, Barbara J Flynn, Lais da Silva Pereira, Yann Le Duff, Mathew Hurley, Adéla Nacer, Paul W Bowyer, Fidel Zavala, Azza H Idris, Joseph R Francica, Robert A Seder, Rogerio Amino

Journal: Cell Rep

PubMed ID: 37389992

Doi: 10.1016/j.celrep.2023.112681

Products & Services: Peptide Synthesis

Folding Double-Stranded DNA into Designed Shapes with Triplex-Forming Oligonucleotides

Authors: Cindy Ng , Anirban Samanta , Ole Aalund Mandrup , Emily Tsang , Sarah Youssef , Lasse Hyldgaard Klausen , Mingdong Dong , Minke A D Nijenhuis , Kurt V Gothelf

Journal: Adv Mater .

PubMed ID: 37311656

Doi: 10.1002/adma.202302497

Products & Services: DNA Sequencing

A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells

Authors: Aoxing Cheng, Tian Xu , Weiyi You, Ting Wang, Dongming Zhang, Huimin Guo , Haiyan Zhang , Xin Pan , Yucai Wang , Liu Liu , Kaiguang Zhang , Jue Shi , Xuebiao Yao ， Jing Guo , Zhenye Yang

Journal: Nat Metab .

PubMed ID: 37349486

Doi: 10.1038/s42255-023-00832-9

Products & Services: Antibody Modification and Purification Services

Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue

Authors: Colin J. Palmer; Raphael J. Bruckner; Joao A. Paulo; Lawrence Kazak; Jonathan Z. Long; Amir I. Mina; Zhaoming Deng; Katherine B. LeClair; Jessica A. Hall; Shangyu Hong; Peter-James H. Zushin; Kyle L. Smith; Steven P. Gygi; Susan Hagen; David E. Cohen; Alexander S. Banks

Journal: Molecular Metabolism

PubMed ID: 29031721

Doi: 10.1016/j.molmet.2017.07.013

Products & Services: Custom Vector Construction

Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue

Journal: Molecular Metabolism

PubMed ID: 29031721

Doi: 10.1016/j.molmet.2017.07.013

Products & Services: Custom Vector Construction

SAM1 domain of SASH1 harbors distinctive structural heterogeneity

Authors: Christopher M. Clements; Beat V geli; Yiqun G. Shellman; Morkos A. Henen

Journal: Journal of structural biology

PubMed ID: 36341956

Doi: 10.1016/j.jsb.2022.107914

Peptide Inhibitor Assay for Allocating Functionally Important Accessible Sites Throughout a Protein Chain: Restriction Endonuclease EcoRI as a Model Protein System

Authors: Joji M. Otaki

Journal: BioTech

PubMed ID: 39846550

Doi: 10.3390/biotech14010001

Products & Services: Peptide Synthesis

Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins

Authors: Xi Wang, Lavi S Bigman, Harry M Greenblatt, Binhan Yu, Yaakov Levy, Junji Iwahara

Journal: Nucleic Acids Res

PubMed ID: 36774964

Doi: 10.1093/nar/gkad045

Products & Services: Molecular Biology Reagents

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

Authors: Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Jason Swinderman, Feiqiao B Yu, Xuchao Lyu, Gemini Skariah, Vishvak Subramanyam, Luke A Gilbert, Hani Goodarzi, Li Lingyin

Journal: biorxiv

PubMed ID: 37333273

Doi: 10.1101/2023.06.01.543353

Products & Services: Protein and Antibody Isolation