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ChemScreener: an active learning enabled hit discovery workflow with WDR5 inhibitor case study

Authors: Lingling Shen; Jian Fang; Lulu Liu; Rena Wang; Jeremy L. Jenkins; He Wang

Journal: Journal of Cheminformatics

PubMed ID: 42010453

Doi: 10.1186/s13321-026-01204-7

Products & Services: Peptide Synthesis

The anthelmintic meclonazepam activates a schistosome transient receptor potential channel

Authors: Sang-Kyu Park; Daniel J. Sprague; Claudia M. Rohr; Evgeny G. Chulkov; Ian Petrow; Sushil Kumar; Jonathan S. Marchant

Journal: The Journal of Biological Chemistry

PubMed ID: 38043794

Doi: 10.1016/j.jbc.2023.105528

Products & Services: Codon Optimization

Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design

Authors: rsula L pez-Garc a; Jan Vietor; Julian A. Marschner; Jan Heering; Vasily Morozov; Thomas Wein; Daniel Merk

Journal: Communications Chemistry

PubMed ID: 40399628

Doi: 10.1038/s42004-025-01553-8

Products & Services: Plasmid DNA Preparation

Artemisinin exerts antidepressant-like effects via activation of AKT and ERK signaling pathways

Authors: Ruohong Lin; Zhiwei Zhou; Yizhou Jiang; Song Liu; Jinfeng Xie; Haitao Wang; Henning Ulrich; Wenhua Zheng

Journal: Frontiers in pharmacology

PubMed ID: 41181594

Doi: 10.3389/fphar.2025.1642167

Products & Services: Protein Electrophoresis and Western

Artemisinin exerts antidepressant-like effects via activation of AKT and ERK signaling pathways

Authors: Ruohong Lin; Zhiwei Zhou; Yizhou Jiang; Song Liu; Jinfeng Xie; Haitao Wang; Henning Ulrich; Wenhua Zheng

Journal: Frontiers in pharmacology

PubMed ID: 41181594

Doi: 10.3389/fphar.2025.1642167

Products & Services: Protein Electrophoresis and Western

Harnessing Microbial Bioremediation and Wastewater Valorization for Production of (Methyl)muconates via Engineered Metabolic Pathways in Aromatic Pollutant Mixtures

Authors: Siqing Fan, Xueni Fu, Xiaoyu Wang, Lvjing Wang, Hongyu Chen, Christopher E French, Hongzhi Tang, Hao Ren, Zhenmei Lu

Journal: Environmental science & technology

PubMed ID: 42049681

Doi: 10.1021/acs.est.5c11064

Products & Services: Gene Synthesis

Revisiting the antizyme 1 - ODC interaction reveals low-nanomolar affinity

Authors: Grzegorz P Bereta, Elżbieta Wątor-Wilk, Paweł Kochanowski, Jakub Nowak, Tomasz Kantyka, Przemysław Grudnik

Journal: Amino Acids

PubMed ID: 41989609

Doi: 10.1007/s00726-026-03519-z

Products & Services: PCR Cloning and Subcloning

Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

Authors: Savanna Skeeters; Kamal Bagale; Galina Stepanyuk; David Thieker; Aaron Aguhob; Kui K. Chan; Benjamin Dutzar; Sergei Shalygin; Asif Shajahan; Xu Yang; Paul A. DaRosa; Emily Frazier; Maximilian M. Sauer; Lisa Bogatzki; Kelly A. Byrnes-Blake; Yifan Song; Parastoo Azadi; Eric Tarcha; Lianghui Zhang; Erik Procko

Journal: Molecular therapy. Methods & clinical development

PubMed ID: 39185275

Doi: 10.1016/j.omtm.2024.101301

Products & Services: Protein and Antibody Reagents

Parishin alleviates vascular ageing in mice by upregulation of Klotho

Authors: Xinxiu Zhao; Shixian Zhou; Yang Liu; Caixia Gong; Lan Xiang; Shumin Li; Peixia Wang; Yuejun Wang; Linlin Sun; Qin Zhang; Yunmei Yang

Journal: Journal of cellular and molecular medicine

PubMed ID: 37032511

Doi: 10.1111/jcmm.17740

Products & Services: Protein Electrophoresis and Western

Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway

Authors: Martina Lerche; Mathilde Mathieu; Hellyeh Hamidi; Megan Chastney; Guillaume Jacquemet; Bart Marlon Herwig Bruininks; Shreyas Kaptan; Lene Maler d; Nina Marie Pedersen; Andreas Brech; Nobuyuki Matoba; Yuichiro Sato; Ilpo Vattulainen; Pere Roca-Cusachs; Franck Perez; Gaelle Boncompain; St phanie Miserey; Johanna Ivaska

Journal: The Journal of cell biology

PubMed ID: 41329164

Doi: 10.1083/jcb.202508155

Products & Services: Peptide Synthesis