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Near-infrared photochromic miniprotein enables photoacoustic molecular imaging of acute inflammation and intracellular antigens

Authors: Olena S Oliinyk, Yirui Xu, Jinhuan Luo, Kateryna O Tokarchuk, Kyrylo Yu Manoilov, Josie van de Klashorst, Matthew P Eyring, Mu-En Wang, Ming Chen, Pengfei Song, John W Hickey, Junjie Yao, Vladislav V Verkhusha

Journal: Nature Methods

PubMed ID: 42870097

Doi: 10.1038/s41592-026-03255-y.

Products & Services: Gene Synthesis

Recordanelles for transcriptome-wide single-cell RNA recording in human cells

Authors: Christopher D Reinkemeier, Marcos Manero-Carranza, Rick Farouni, Federica Filice, Alexander Klotz, Konstantin Schneider-Heieck, Tim L Andermann, Randall J Platt

Journal: Nature Biotechnology

PubMed ID: 42907534

Doi: 10.1038/s41587-026-03327-6

Products & Services: Gene Synthesis

Cardiomyocyte-enriched OTUD5 alleviates pathological myocardial hypertrophy by deubiquitinating STAT3 and modulating the STAT3–PGC-1α axis

Authors: Bozhi Ye, Yucheng Jiang, Zhaozheng Zheng, Yanhong Jin, Yingjie Liao, Zhihan Jia, Wante Lin, Diyun Xu, Jibo Han, Zimin Fang, Naijin Zhang, Peiren Shan, Gaojun Wu, Guang Liang

Journal: experimental & molecular medicine

PubMed ID: 42888217

Doi: 10.1038/s12276-026-01870-5

Keratin 9 regulates mechanosensitive YAP1 signalling in palmoplantar epidermis

Authors: Sarah N. Steiner, Eric N. Horst, Evelyn S. Chiu, Mitre Athaiya, Craig N. Johnson, Joseph Y. Shen, Michelle L. Kerns, Joseph D. Kirma, Rebecca L. McCarthy, Syed F. H. Shah, Ofer Sarig, Liat Samuelov, Eli Sprecher, Edel A. O’Toole, Johann E. Gudjonsson, Geeta Mehta, Ramiro Iglesias-Bartolome, Pierre A. Coulombe

Journal: Nature Cell Biology

PubMed ID: 42918816

Doi: 10.1038/s41556-026-02087-4

Neuron-Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65-Mediated ANXA2 Degradation

Authors: Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji

Journal: Advanced Science

PubMed ID: 42885139

Doi: 10.1002/advs.77808

Cis-regulatory inactivation of vitamin D signaling confers extreme calcium tolerance in Jialing fish

Authors: Nan Zhang, Yongsen Zhou, Jianbin Feng, Tianhao Yang, Huilin Liu, Yongsheng Zhang, Lingyun Chen, Weiyang Xiao, Tai Wang, Aaron J W Hsueh, Jianzhen Li

Journal: Science advences

PubMed ID: 42842657

Doi: 10.1126/sciadv.aeg8398

Products & Services: Synthetic Guide RNA

Enzymes can activate and mobilize dense biomolecular condensates across scales

Authors: Mirco Dindo, Jakob Metson, Weitong Ren, Michalis Chatzittofi, Kiyoshi Yagi, Alessandro Bevilacqua, Erika Fukuhara, Yuji Sugita, Ramin Golestanian, Paola Laurino

Journal: Nature Communications

PubMed ID: 42963352

Doi: 10.1038/s41467-026-77666-y

Products & Services: Molecular Biology Tools

Innate sensor responses set a supra-unitary threshold for viral replication

Authors: Kojiro Mukai, Dongya Jia, Mamata Panigrahi, Thomas Tayman, Graham Brogden, Ying-Han Chen, Nazmul Haque, Gunjan Arora, Joshua E Mutterperl, Ian Poe, Chenyu Zhang, Zahin Islam, Ronald Holewinski, Thorkel Andresson, Di Wu, Grzegorz Piszczek, Joseph Marcotrigiano, J Robert Hogg, Suk See De Ravin, Nasir S Malik, Avindra Nath, Ekaterina Viktorova, Anna Zimina, George A Belov, Banu Bayyurt-Kocabaş, Grégoire Altan-Bonnet, Nihal Altan-Bonnet

Journal: Cell

PubMed ID: 42956738

Doi: 10.1016/j.cell.2026.10.004

Products & Services: Catalog IVT RNA products

IRF2BP2-FOSL2 interaction regulates SOX9-mediated cartilage regeneration in osteoarthritis models

Authors: Hao Zhou, Tiantian Lu, Zhuoqun Gao, Can Cui, Zhiqiang Fang, Yu You, Jing Jiang, Jinjin Xu, Fang Wei, Jing Yu, Hu Zhou, Jinsong Li, Jian Luo, Lei Zhang, Yunyun Jin

Journal: JOURNAL OF CLINICAL INVESTIGATION

PubMed ID: 42878073

Doi: 10.1172/JCI200039

Products & Services: Peptide Synthesis

Interpretable AI-guided discovery of degradable ionizable lipids with enhanced hepatic mRNA delivery in vivo

Authors: Zhen Zhang, Yongbo Ren, Deqiang Kong, Jindong Feng, Kaiyi Hu, Xinyun Xu, Fukang Deng, Peixia Li, Jiuao Wang, Wenhui Huang, Guodan Wei, Yang Su, Ying Tan, Shuixing Zhang, Xiaodan Sun, Feiyu Kang, Hao Yan

Journal: nature communications

Doi: doi.org/10.1038/s41467-026-78635-1

Products & Services: Custom mRNA synthesis