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Complete integration of carbene-transfer chemistry into biosynthesis

Authors: Jing Huang, Andrew Quest, Pablo Cruz-Morales, Kai Deng, Jose Henrique Pereira, Devon Van Cura, Ramu Kakumanu, Edward E K Baidoo, Qingyun Dan, Yan Chen, Christopher J Petzold, Trent R Northen, Paul D Adams, Douglas S Clark, Emily P Balskus, John F Hartwig, Aindrila Mukhopadhyay, Jay D Keasling

Journal: Nature

PubMed ID: 37138074

Doi: 10.1038/s41586-023-06027-2

Products & Services: Recombinant Proteins

Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis

Authors: Stephanie M Bozonet, Nicholas J Magon, Abigail J Schwartfeger, Andreas Konigstorfer, Sarah G Heath, Margreet C M Vissers, Vanessa K Morris, Christoph Göbl, James M Murphy, Guy S Salvesen, Mark B Hampton

Journal: J Biol Chem

PubMed ID: 37150321

Doi: 10.1016/j.jbc.2023.104792

Products & Services: Molecular Biology Reagents

De Novo Computational Design of a Lipase with Hydrolysis Activity towards Middle-Chained Fatty Acid Esters

Authors: Jinsha Huang, Xiaoman Xie, Zhen Zheng, Luona Ye, Pengbo Wang, Li Xu, Ying Wu, Jinyong Yan, Min Yang, Yunjun Yan

Journal: Int J Mol Sci

PubMed ID: 37239928

Doi: 10.3390/ijms24108581

Products & Services: Gene Synthesis

Sel1-like proteins and peptides are the major -derived factors stimulating oxalate transport by human intestinal epithelial cells

Authors: Donna Arvans, Changsoo Chang, Altayeb Alshaikh, Christine Tesar, Gyorgy Babnigg, Don Wolfgeher, Stephen Kron, Dionysios Antonopoulos, Mohamed Bashir, Candace Cham, Mark Musch, Eugene Chang, Andrzej Joachimiak, Hatim Hassan

Journal: Am J Physiol Cell Physiol

PubMed ID: 37125773

Doi: 10.1152/ajpcell.00466.2021

Products & Services: Peptide Synthesis

Electronegative clusters modulate folding status and RNA binding of unstructured RNA-binding proteins

Authors: Steve Zaharias, Talia Fargason, Rory Greer, Yuhua Song, Jun Zhang

Journal: Protein Sci

PubMed ID: 37060324

Doi: 10.1002/pro.4643

Products & Services: Gene Synthesis

Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa

Authors: Xingyun Wang, Cong Liu, Nino Rcheulishvili, Dimitri Papukashvili, Fengfei Xie, Jiao Zhao, Xing Hu, Kaiwei Yu, Nuo Yang, Xuehua Pan, Xueyan Liu, Peng George Wang, Yunjiao He

Journal: npj Vaccines

PubMed ID: 37231060

Doi: 10.1038/s41541-023-00672-4

Products & Services: Polyclonal Antibody Services

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

Authors: Joka Pipercevic, Bastian Kohl, Ruta Gerasimaite, Véronique Comte-Miserez, Sarah Hostachy, Thomas Müntener, Elia Agustoni, Henning Jacob Jessen, Dorothea Fiedler, Andreas Mayer, Sebastian Hiller

Journal: Nat Commun

PubMed ID: 37156835

Doi: 10.1038/s41467-023-38315-w

Products & Services: Molecular Biology Reagents

In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution

Authors: Lisandro J González, Guillermo Bahr, Mariano M González, Robert A Bonomo, Alejandro J Vila

Journal: Nat Chem Biol

PubMed ID: 37188957

Doi: 10.1038/s41589-023-01319-0

Products & Services: Gene Synthesis

Validation of immunoassays for the Chlamydia trachomatis antigen Pgp3 using a chimeric monoclonal antibody

Authors: Brook Goodhew, Xiaoling Tang, Jason Goldstein, Joo Lee, Diana Martin, Sarah Gwyn

Journal: Sci Rep

PubMed ID: 37142607

Doi: 10.1038/s41598-023-33834-4

Products & Services: Protein and Antibody Isolation

Small-Molecule-Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death

Authors: Rita A Avelar, Amy J Armstrong, Gracie Carvette, Riya Gupta, Noah Puleo, Jose A Colina, Peronne Joseph, Alexander M Sobeck, Caitlin M O'Connor, Brynne Raines, Agharnan Gandhi, Michele L Dziubinski, Daniel S Ma, Kimberly Resnick, Sareena Singh, Kristine Zanotti, Christa Nagel, Steven Waggoner, Daffyd G Thomas, Stephanie L Skala, Junran Zhang, Goutham Narla, Analisa DiFeo

Journal: Mol Cancer Ther

PubMed ID: 36788429

Doi: 10.1158/1535-7163.MCT-21-0880

Products & Services: CRISPR Plasmids