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Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment

Authors: Derek Allen, Samerender Nagam Hanumantharao, Rylie McDonell, Karen-Amanda Irvine, Peyman Sahbaie, David Clark, Paul Blum

Journal: Sci Rep

PubMed ID: 37479740

Doi: 10.1038/s41598-023-38618-4

Products & Services: Protein and Antibody Isolation

Low cross reactivity between wild type and deamidated AAV can lead to false negative results in immune monitoring T-cell assays

Authors: So Jin Bing, Stephanee Warrington, Ronit Mazor

Journal: Front Immunol

PubMed ID: 37469509

Doi: 10.3389/fimmu.2023.1211529

Products & Services: Protein and Antibody Isolation

An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma

Authors: Akinsola Oyelakin, Jennifer Sosa, Kasturi Bala Nayak, Alexandra Glathar, Christian Gluck, Isha Sethi, Maria Tsompana, Norma Nowak, Michael Buck, Rose-Anne Romano, Satrajit Sinha

Journal: NAR Cancer

PubMed ID: 37492374

Doi: 10.1093/narcan/zcad038

Products & Services: Plasmid DNA Preparation

Peptide/Nanoparticle Biointerfaces for Multistep Tandem Catalysis

Authors: Yuliana Perdomo, Joseph M Slocik, David M Phillips, Marc R Knecht

Journal: J Am Chem Soc

PubMed ID: 37478168

Doi: 10.1021/jacs.3c04097

Products & Services: Peptide Synthesis

A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury

Authors: Chen Yang, Huidie Xu, Dong Yang, Yunhao Xie, Mingrui Xiong, Yu Fan, XiKai Liu, Yu Zhang, Yushuo Xiao, Yuchen Chen, Yihao Zhou, Liangliang Song, Chen Wang, Anlin Peng, Robert B Petersen, Hong Chen, Kun Huang, Ling Zheng

Journal: Nat Commun

PubMed ID: 37460623

Doi: 10.1038/s41467-023-40036-z

Products & Services: Peptide Synthesis Protein portfolio

Systemic delivery of specific and efficient CRISPR/Cas9 system targeting HPV16 oncogenes using LL-37 antimicrobial peptide in C57BL/6 mice

Authors: Niloofar Khairkhah, Azam Bolhassani, Farzad Rajaei, Reza Najafipour

Journal: J Med Virol

PubMed ID: 37403986

Doi: 10.1002/jmv.28934

Products & Services: Custom DNA/RNA Oligos

Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine

Authors: Peter J. Halfmann; Kathryn Loeffler; Augustine Duffy; Makoto Kuroda; Jie E. Yang; Elizabeth R. Wright; Yoshihiro Kawaoka; Ravi S. Kane

Journal: Nature Communications

PubMed ID: 38346966

Doi: 10.1038/s41467-024-45495-6

Products & Services: PCR Cloning and Subcloning

Structure-based design of SARS-CoV-2 papain-like protease inhibitors

Authors: Prakash Jadhav; Bo Huang; Jerzy Osipiuk; Xiaoming Zhang; Haozhou Tan; Christine Tesar; Michael Endres; Robert Jedrzejczak; Bin Tan; Xufang Deng; Andrzej Joachimiak; Jianfeng Cai; Jun Wang

Journal: European Journal of Medicinal Chemistry

PubMed ID: 38065031

Doi: 10.1016/j.ejmech.2023.116011

A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer

Authors: Emily Maria Ploeg, Isabel Britsch, Anne Paulien van Wijngaarden, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Douwe Freerk Samplonius, Wijnand Helfrich

Journal: Cancers (Basel)

PubMed ID: 37509310

Doi: 10.3390/cancers15143651

Products & Services: Gene Synthesis

The structure and mechanism of action of a distinct class of dicistrovirus intergenic region IRESs

Authors: Irina S Abaeva , Christina Young , Reid Warsaba , Nadiyah Khan , Lan Vy Tran , Eric Jan , Tatyana V Pestova , Christopher U T Hellen

Journal: Nucleic Acids Res .

PubMed ID: 37427788

Doi: 10.1093/nar/gkad569

Products & Services: Polyclonal Antibody Services Gene Synthesis