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Comparative analysis of adenovirus, mRNA, and protein vaccines reveals context-dependent immunogenicity and efficacy

Authors: Bakare Awakoaiye, Shiyi Li, Sarah Sanchez, Tanushree Dangi, Nahid Irani, Laura Arroyo, Gabriel Arellano, Shadi Mohammadabadi, Malika Aid, Pablo Penaloza-MacMaster

Journal: JCI Insight

PubMed ID: 41212056

Doi: 10.1172/jci.insight.198069

Products & Services: Custom mRNA synthesis

TIPIN coordinates ATM-dependent checkpoint and NF-κB signaling to counteract DNA replication damage from topoisomerase inhibition

Authors: Arafat Khan, Justin F Lim, Natalie Lo, Jinal A Patel, John Haley, Hyungjin Kim

Journal: Communications biology

PubMed ID: 41291151

Doi: 10.1038/s42003-025-09084-7

Products & Services: Polyclonal Antibody Services

Genetics of cystogenesis in base edited human organoids reveal therapeutic strategies for polycystic kidney disease

Authors: Courtney E. Vishy; Chardai Thomas; Thomas Vincent; Daniel K. Crawford; Matthew M. Goddeeris; Benjamin S. Freedman

Journal: Cell Stem Cell

PubMed ID: 38579684

Doi: 10.1016/j.stem.2024.03.005

Products & Services: Plasmid DNA Preparation

The Sobering Sting: Oleoyl Serotonin Is a Novel Stephanoconus Snail Venom-Derived Antagonist of Cannabinoid Receptors That Counteracts Learning and Memory Deficits

Authors: Dongchen An; Guilherme Salgado Carrazoni; Ben-Hur Souto das Neves; Rudi D Hooge; Steve Peigneur; Jan Tytgat

Journal: Biomedicines

PubMed ID: 38398056

Doi: 10.3390/biomedicines12020454

Products & Services: Custom Vector Construction

On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models

Authors: Filippo Birocchi, Antonio J Almazan, Aiyana Parker, Amanda A Bouffard, Sadie Goncalves, Christopher Kelly, Jessica Frank, Mark B Leick, Nicholas J Haradhvala, Shaw Kagawa, Gad Getz, Giulia Escobar, Diego Salas-Benito, Adele Mucci, Trisha R Berger, Marcela V Maus

Journal: Nature Communications

PubMed ID: 41176533

Doi: 10.1038/s41467-025-61858-z.

Products & Services: Monoclonal Antibody Services

Generation of antigen-specific paired-chain antibodies using large language models

Authors: Perry T Wasdin, Nicole V Johnson, Alexis K Janke, Sofia Held, Toma M Marinov, Gwen Jordaan, Rebecca A Gillespie, Léna Vandenabeele, Fani Pantouli, Olivia C Powers, Matthew J Vukovich, Clinton M Holt, Jeongryeol Kim, Grant Hansman, Jennifer Logue, Helen Y Chu, Sarah F Andrews, Masaru Kanekiyo, Giuseppe A Sautto, Ted M Ross, Daniel J Sheward, Jason S McLellan, Alexandra A Abu-Shmais, Ivelin S Georgiev

Journal: Cell

PubMed ID: 41192421

Doi: 10.1016/j.cell.2025.10.006.

Products & Services: Protein and Antibody Isolation

A plastid carbohydrate carrier mediates ribose recycling from nucleotide catabolism and glucose export from starch degradation

Authors: Luisa Voß, Isabel Keller, Rebekka Schröder, Denise Mehner-Breitfeld, André Specht, Gerald Dräger, Jannis Rinne, Jakob Franke, Nieves Medina-Escobar, Marco Herde, Thomas Brüser, H Ekkehard Neuhaus, Claus-Peter Witte

Journal: Nature Communications

PubMed ID: 41193506

Doi: 10.1038/s41467-025-65510-8

Products & Services: Monoclonal Antibody Services

Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii

Authors: Silvia Diaz-Martin, Christopher Swale, Valeria Bellini, Irina Dobrescu, Janine Wenker, Marie-Pierre Brenier-Pinchart, Laurence Braun, Alwéna Tollec, Charlotte Corrao, Yohann Couté, Caroline Mas, Fabrice Laurent, Matthew Bowler, Mohamed-Ali Hakimi, Alexandre Bougdour

Journal: Nature Communications

PubMed ID: 41193440

Doi: 10.1038/s41467-025-64701-7.

Products & Services: Gene Synthesis

A chromosome-level genome of Astilbe chinensis unveils the evolution of a terpene biosynthetic gene cluster

Authors: Fangfang Chen, Yan Yao, Hangzhi Zhu, Jie Hu, Aohan Geng, Zhenni Xu, Xueting Fang, Weijia Cheng, Yao Zhi, Yonghong Zhang, Zixin Deng, Tiangang Liu, Li Lu

Journal: Nature Communications

PubMed ID: 41213911

Doi: 10.1038/s41467-025-64842-9.

Products & Services: Protein and Antibody Isolation

Plexin-B1 safeguards astrocyte agility and glial alignment to facilitate wound corralling and axon pathfinding in mouse spinal cord injury model

Authors: Haofei Ni, Zhilai Zhou, Molly Estill, Dalia Halawani, Chrystian Junqueira Alves, Li Shen, Ning Xie, Roland H Friedel, Hongyan Zou

Journal: Nature Communications

PubMed ID: 41253783

Doi: 10.1038/s41467-025-65095-2.

Products & Services: Protein Electrophoresis and Western