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RNA Pol II inhibition activates cell death independently from the loss of transcription

Authors: Nicholas W Harper, Gavin A Birdsall, Megan E Honeywell, Kelly M Ward, Athma A Pai, Michael J Lee

Journal: Cell

PubMed ID: 40818455

Doi: 10.1016/j.cell.2025.07.034

Products & Services: Peptide Synthesis

Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM

Authors: James A Ferguson, Sai Sundar Rajan Raghavan, Garazi Peña Alzua, Disha Bhavsar, Jiachen Huang, Alesandra J Rodriguez, Jonathan L Torres, Maria Bottermann, Julianna Han, Florian Krammer, Facundo D Batista, Andrew B Ward

Journal: SCIENCE ADVANCES

PubMed ID: 40815640

Doi: 10.1126/sciadv.adv8257

Products & Services: Recombinant Antibody Expression

Structural basis for small molecule binding to the SARS-CoV-2 nsp10-nsp14 ExoN complex

Authors: Frank Kozielski, Suzanne Zoë Fisher, Shumeng Ma, Fatma Al Busaidi, Ewa Krupinska, Maria Nyblom, Céleste Sele, Heather McDuffie Sullivan, Tobias Krojer, Wolfgang Knecht

Journal: Nucleic Acids Research

PubMed ID: 40794865

Doi: 10.1093/nar/gkaf753

Products & Services: Codon Optimization

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats

Authors: Laurent Martin, Harrison J Stratton, Lyuba Y Salih, Nicolas LA Dumaire, Kimberly Gomez, Le Duy Do, Santiago Loya-Lopez, Cheng Tang, Aida Calderon-Rivera, Dongzhi Ran, Venkatrao Nunna, Shreya S Bellampalli, Liberty François-Moutal, Shizhen Luo, Frank Porreca, Mohab Ibrahim, Véronique Rogemond, Jérôme Honnorat, Rajesh Khanna, Aubin Moutal

Journal: Nature Communications

PubMed ID: 40775229

Doi: 10.1038/s41467-025-62380-y.

Products & Services: Peptide Synthesis

Iterative recombinase technologies for efficient and precise genome engineering across kilobase to megabase scales

Authors: Chao Sun, Hongchao Li, Yijing Liu, Jinxing Liu, Ronghong Liang, Caixia Gao

Journal: Cell

PubMed ID: 40763736

Doi: 10.1016/j.cell.2025.07.011

Products & Services: Gene Synthesis

Lactate-Modulating Nanoreactors Facilitate Self-Amplifying Pyroptosis and the cGAS-STING Cascade for Potentiated Catalytic-Immunotherapy

Authors: Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng

Journal: Advanced Science

PubMed ID: 40874418

Doi: 10.1002/advs.202511144

Products & Services: Protein and Antibody Isolation

Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

Authors: Yang Yue, Chanjuan Xu, Lijie Wu, Man Na, Kexin Xu, Xuan Chen, Yuxuan Song, Sichun Weng, Lu Xu, Fei Li, Xi Lin, Arthur Wang, Jianfeng Liu, Fei Xu

Journal: Nature Communications

PubMed ID: 40790299

Doi: doi.org/10.1038/s41467-025-62870-z

Products & Services: Gene Synthesis

Camel-Milk-Derived Extracellular Vesicles Mitigate High-Fat-DietInduced Obesity by Enhancing Thermogenesis and Modulating Lipid Metabolism in Mice

Authors: Shuai Wang, Shuting Liu, Ting He, Huanming Shen, Chunli Mo, Yu Zhu, Wenlo, Weihua Li, Jian Zhang

Journal: Journal of Agricultural and Food Chemistry

PubMed ID: 40810347

Doi: doi.org/10.1021/acs.jafc.5c02577

Products & Services: Catalog Antibodies

Senescence-regulating agents remodel mesenchymal stem cell-schwann cell circuitry for diabetic bone regeneration

Authors: An Lao, Yiting Sun, Weiqi Li, Yu Zhuang, Ziyang Liu, Chenci Xu, Xiangbing Wu, Linhu Ge, Kaili Lin, Jianyong Wu, Jing Mao, Jiaqiang Liu

Journal: Biomaterials

PubMed ID: 40916241

Doi: 10.1016/j.biomaterials.2025.123656

Products & Services: Protein and Antibody Isolation

Human monoclonal antibodies targeting A35 protect from death caused by mpox

Authors: Raianna F. Fantin, Meng Yuan, Seok-Chan Park, Bailey Bozarth, Hallie Cohn, Maxinne Ignacio, Patricia Earl, Alesandro Civljak, Gabriel Laghlali, Ding Zhang, Xueyong Zhu, Jameson Crandell, Valter Monteiro, Jordan J. Clark, Catherine Cotter, Martin Burkhardt, Gagandeep Singh, Prajakta Warang, Juan García-Bernalt Diego, Komal Srivastava, Luz A. Lugo, Lauren Pischel, PVI study group, Inci Yildirim, Saad B. Omer, Daniel da Silva, Florian Krammer, Goran Bajic, Viviana Simon, Michael Schotsaert, Carolina Lucas, Ian A. Wilson, Bernard Moss, Camila H. Coelho

Journal: Cell

Doi: 10.1016/j.cell.2025.08.004

Products & Services: DNA Sequencing