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Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity
Authors: Benedikt Goretzki, Christoph Wiedemann, Brett A McCray, Stefan L Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Ainara Claveras Cabezudo, Jack K Donohue, Cy M Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J Sumner, Gerhard Hummer, Ute A Hellmich
Journal: Nat Commun
PubMed ID: 37443299
Doi: 10.1038/s41467-023-39808-4
Products & Services: Plasmid DNA Preparation   
Absolute Quantification of Photoreceptor Outer Segment Proteins
Authors: Nikolai P Skiba, Tylor R Lewis, William J Spencer, Carson M Castillo, Andrej Shevchenko, Vadim Y Arshavsky
Journal: J Proteome Res
PubMed ID: 37493966
Doi: 10.1021/acs.jproteome.3c00267
Products & Services: Peptide Synthesis   
Computationally Designed Small Molecules Disassemble Both Soluble Oligomers and Protofibrils of Amyloid β-Protein Responsible for Alzheimer's Disease
Authors: Yingying Jin, Matthew A Downey, Ambuj Singh, Steven K Buratto, Michael T Bowers
Journal: ACS Chem Neurosci
PubMed ID: 37442126
Doi: 10.1021/acschemneuro.3c00266
Products & Services: Protein and Antibody Isolation   
TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma
Authors: Niranjana Amin, Herui Wang, Qi Song, Manju Bhaskar, Sharda Prasad Yadav, Mark R Gilbert, Harish Pant, Emeline Tabouret, Zhengping Zhuang
Journal: Int J Mol Sci
PubMed ID: 37511490
Doi: 10.3390/ijms241411733
Products & Services: Peptide Synthesis   
Structural basis of CXC chemokine receptor 1 ligand binding and activation
Authors: Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri, Kenji Mizutani, Satoko Akashi, Jeremy R H Tame, Asuka Inoue, Sam-Yong Park
Journal: Nat Commun
PubMed ID: 37433790
Doi: 10.1038/s41467-023-39799-2
Products & Services: Gene Synthesis   
Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis
Authors: Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang, Lihui Yang, Jingxiao Wang, Meijuan Wan, Diego F Calvisi, Shumei Lin, Xin Chen, Haichuan Wang
Journal: Cell Death Dis
PubMed ID: 37500626
Doi: 10.1038/s41419-023-05958-y
Products & Services: Catalog Peptides   
Class I histone deacetylase complex: Structure and functional correlates
Authors: Xiao Wang, Yannan Wang, Simiao Liu, Yi Zhang, Ke Xu, Liting Ji, Roger D Kornberg, Heqiao Zhang
Journal: Proceedings of the National Academy of Sciences of the United States of America
PubMed ID: 37459529
Doi: 10.1073/pnas.2307598120
Products & Services: Gene Synthesis   Custom Vector Construction   
The combination of osimertinib with Raf inhibitor overcomes osimertinib resistance induced by KRAS amplification in EGFR-mutated lung cancer cells
Authors: Tae-Gul Lee, Hye-Min Kang, Seo Yun Kim, Hye-Ryoun Kim, Cheol Hyeon Kim
Journal: Exp Cell Res
PubMed ID: 37442265
Doi: 10.1016/j.yexcr.2023.113722
Products & Services: Protein and Antibody Isolation   
Targeting CXCR4-expressing Cancer Cells with Avidin-poly (lactic-co-glycolic acid) Nanoparticle Surface Modified with Biotinylated DV1 Peptide
Authors: Shiba Ansari, Madeeha Mudassir, B Vijayalekshmi, Parthaprasad Chattopadhyay
Journal: Int J Appl Basic Med Res
PubMed ID: 37614837
Doi: 10.4103/ijabmr.ijabmr_58_23
Products & Services: Peptide Synthesis   
Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results
Authors: Raffit Hassan, Marcus Butler, Roisin E O'Cearbhaill, David Y Oh, Melissa Johnson, Kevin Zikaras, Munisha Smalley, Michael Ross, Janos L Tanyi, Azam Ghafoor, Nirali N Shah, Babak Saboury, Liang Cao, Alfonso Quintás-Cardama, David Hong
Journal: Nat Med
PubMed ID: 37501016
Doi: 10.1038/s41591-023-02452-y
Products & Services: Protein and Antibody Isolation   
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