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LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility

Authors: Jae Yeon Hwang, Pengxin Chai, Shoaib Nawaz, Jungmin Choi, Francesc Lopez-Giraldez, Shabir Hussain, Kaya Bilguvar, Shrikant Mane, Richard P Lifton, Wasim Ahmad, Kai Zhang, Jean-Ju Chung

Journal: Elife

PubMed ID: 38091523

Doi: 10.7554/eLife.9009

Products & Services: ORF cDNA Clones/MolecularCloud

Characterization of chronic relapsing antibody mediated arthritis in mice with a mutation in Ncf1 causing reduced oxidative burst

Authors: Peibin Liang; Yanpeng Li; Rui Xu; Kutty Selva Nandakumar; Roma Stawikowska; Gregg B. Fields; Rikard Holmdahl

Journal: Molecular Biomedicine

PubMed ID: 35551534

Doi: 10.1186/s43556-022-00076-1

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations

Authors: Fr d ric A. Dreyer; Constantin Schneider; Aleksandr Kovaltsuk; Daniel Cutting; Matthew J. Byrne; Daniel A. Nissley; Henry Kenlay; Claire Marks; David Errington; Richard J. Gildea; David Damerell; Pedro Tizei; Wilawan Bunjobpol; John F. Darby; Ieva Drulyte; Daniel L. Hurdiss; Sachin Surade; Newton Wahome; Douglas E.V. Pires; Charlotte M. Deane

Journal: MAbs

PubMed ID: 40458889

Doi: 10.1080/19420862.2025.2511220

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations

Journal: MAbs

PubMed ID: 40458889

Doi: 10.1080/19420862.2025.2511220

Characterization of chronic relapsing antibody mediated arthritis in mice with a mutation in Ncf1 causing reduced oxidative burst

Authors: Peibin Liang; Yanpeng Li; Rui Xu; Kutty Selva Nandakumar; Roma Stawikowska; Gregg B. Fields; Rikard Holmdahl

Journal: Molecular Biomedicine

PubMed ID: 35551534

Doi: 10.1186/s43556-022-00076-1

Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens

Authors: David Lund; Roelof Dirk Coertze; Marcos Parras-Molt ; Fanny Berglund; Carl-Fredrik Flach; Anna Johnning; D. G. Joakim Larsson; Erik Kristiansson

Journal: Communications Biology

PubMed ID: 37537271

Doi: 10.1038/s42003-023-05174-6

High-fidelity large-diversity monoclonal mammalian cell libraries by cell cycle arrested recombinase-mediated cassette exchange

Authors: Chuan Chen, Zening Wang, Minhyo Kang, Ki Baek Lee, Xin Ge

Journal: Nucleic Acids Res

PubMed ID: 37941133

Doi: 10.1093/nar/gkad1001

Products & Services: Protein and Antibody Isolation

In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma

Authors: Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38109533

Doi: 10.1073/pnas.2313009120

Products & Services: Protein and Antibody Isolation

Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor

Authors: Masaru Goto, Natsumi Sakamoto, Shoko Higashi, Rena Kawata, Kazuki Nagatsu, Ryota Saito

Journal: J Enzyme Inhib Med Chem

PubMed ID: 37259593

Doi: 10.1080/14756366.2023.2219038

Products & Services: Protein and Antibody Isolation

Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway

Authors: Hui Zhang, Huihua Wang, Qing Zhang, Hui Wang, Yuhang Zhu, Fangfang Wang, Jun Lin, Jue Zhou, Fan Qu