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Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation

Authors: Edgar J. Soto-Moreno, Nourhan N. Ali, Florian Küllmer, Veselin Nasufovic, Michaela Frolikova, Olga Tepla, Jaromir Masata, Dirk Trauner, Amanda A. Patterson, Hans-Dieter Arndt, Katerina Komrskova, Magdalena Zernicka-Goetz, David M. Glover & Ahmed Z. Balboula

Journal: Nature Communications

PubMed ID: 40973727

Doi: 10.1038/s41467-025-63586-w

Products & Services: Gene Services

α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion

Authors: Canqi Cui, Danielle C Leander, Sarah M Gray, Kimberley El, Alex Chen, Paul A Grimsrud, Jessica O Becker, Austin Taylor, Guo-Fang Zhang, Kyle W Sloop, C Bruce Verchere, Andrew N Hoofnagle, David A D'Alessio, Jonathan E Campbell

Journal: SCIENCE ADVANCES

PubMed ID: 40971442

Doi: 10.1126/sciadv.ady8048

Translesion DNA polymerases Rev1 and PolH promote LTR-retrotransposon transcription by safeguarding Pol II occupancy in both germline and somatic tissues of Drosophila

Authors: Chongyang Li, Zhe Meng, Qiuju Wen, Wenjuan Yang, Yaqian Xu, Yuening Lyu, Yile Guo, Tong Lyu, Dan Shen, Kun Dou

Journal: Nucleic Acids Research

PubMed ID: 40966519

Doi: 10.1093/nar/gkaf903

Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect

Authors: Bin Liu, Yansi Xian, Tao Shen, Yu Ben, Wenshu Wu, Yong Shi, Xueying An, Rui Peng, Wentian Gao, Wang Gong, Xiang Chen, Baosheng Guo, Qing Jiang

Journal: Journal of extracellular vesicles

PubMed ID: 40919882

Doi: 10.1002/jev2.70162

Products & Services: Protein and Antibody Isolation

PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity

Authors: Shen Yang, Eugenio Santelli, Carlos G Gonzalez, Wade T Johnson, Irene V Choi, Chuling Zhuang, Myungja Ro, Leigh-Ana M Rossitto, I-Shing Yu, Shu-Wha Lin, Yuan Zhan, Qinwei Chen, Jonathan D Yoshihara, Daniel J Wallace, Caroline A Jefferies, Michifumi Yamashita, David J Gonzalez, Richard I Ainsworth, Nisarg J Shah, Stephanie M Stanford, Nunzio Bottini

Journal: SCIENCE ADVANCES

PubMed ID: 40911684

Doi: 10.1126/sciadv.adw2568

Products & Services: Gene Services

Molecular Chain Elongation Mechanism for n-Caproate Biosynthesis by Megasphaera Hexanoica

Authors: Byoung Seung Jeon, Eun-Jung Kim, Hogyun Seo, Hyunjin Kim, Seungjin Shin, Caroline Schlaiß, Largus T Angenent, Kyung-Jin Kim, Byoung-In Sang

Journal: Advanced Science

PubMed ID: 40932660

Doi: 10.1002/advs.202506069

The TaCEP15 peptide signaling cascade modulates primary root length and drought tolerance in wheat

Authors: Wen Yang, Renhan Li, Man Feng, Zhen Qin, Yumei Zhang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Zhongfu Ni, Wen Song, Feng Qin, Fuminori Takahashi, Qixin Sun, Mingming Xin

Journal: SCIENCE ADVANCES

PubMed ID: 40901958

Doi: 10.1126/sciadv.ady1949

Products & Services: Peptide Services

TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression

Authors: Liangmin Fu, Wuyuan Liao, Youyan Tan, Hansen Lin, Kun Ye, Xinwei Zhou, Mingjie Lin, Kangbo Huang, Minyu Chen, Jietao Wei, Haoqian Feng, Yuhang Chen, Jinwei Chen, Bohong Guan, Shan Li, Zhengkun Zhang, Anze Yu, Zihao Feng, Lizhen Zhang, Guannan Shu, Jun Lu, Wei Chen, Yihui Pan, Jiefeng Yang, Junhang Luo, Li Luo

Journal: Advanced Science

PubMed ID: 40948085

Doi: 10.1002/advs.202506367

Products & Services: Peptide Services

Controllable Generation of Pathogen-Specific Antimicrobial Peptides Through Knowledge-Aware Prompt Diffusion Model

Authors: Yongkang Wang, Menglu Li, Feng Huang, Minyao Qiu, Wen Zhang

Journal: Advanced Science

PubMed ID: 40953451

Doi: 10.1002/advs.202507457

Products & Services: Peptide Services

Covariation MS uncovers a protein that controls cysteine catabolism

Authors: Haopeng Xiao, Martha Ordonez, Emma C. Fink, Taylor A. Covington, Hilina B. Woldemichael, Junyi Chen, Mika Sarkin Jain, Milan H. Rohatgi, Shelley M. Wei, Nils Burger, Muneeb A. Sharif, Julius Jan, Yaoyu Wang, Jonathan J. Petrocelli, Katherine Blackmore, Amanda L. Smythers, Bingsen Zhang, Matthew Gilbert, Hakyung Cheong, Sumeet A. Khetarpal, Arianne Smith, Dina Bogoslavski, Yu Lei, Laura Pontano Vaites, …Edward T. Chouchani

Journal: https://www.nature.com/ Nature

PubMed ID: 40963025

Doi: 10.1038/s41586-025-09535-5