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Dissecting a two-domain alginate lyase of family PL6 reveals a mechanistic basis for substrate specificity and enzyme activity

Authors: Mikkel Madsen; Mette E. R nne; Agnes B. Petersen; Tobias Tandrup; Bo Pilgaard; Jesper Holck; Finn L. Aachmann; Casper Wilkens; Leesa J. Klau; Birte Svensson

Journal: The Journal of Biological Chemistry

PubMed ID: 41638429

Doi: 10.1016/j.jbc.2026.111227

Dissecting a two-domain alginate lyase of family PL6 reveals a mechanistic basis for substrate specificity and enzyme activity

Authors: Mikkel Madsen; Mette E. R nne; Agnes B. Petersen; Tobias Tandrup; Bo Pilgaard; Jesper Holck; Finn L. Aachmann; Casper Wilkens; Leesa J. Klau; Birte Svensson

Journal: The Journal of Biological Chemistry

PubMed ID: 41638429

Doi: 10.1016/j.jbc.2026.111227

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Authors: Bipin Rimal, Stephanie L Collins, Ceylan E Tanes, Edson R Rocha, Megan A Granda, Sumeet Solanki, Nushrat J Hoque, Emily C Gentry, Imhoi Koo, Erin R Reilly, Fuhua Hao, Devendra Paudel, Vishal Singh 11, Tingting Yan 12, Min Soo Kim 2, Kyle Bittinger 3, Joseph P Zackular 13 14, Kristopher W Krausz 12, Dhimant Desai 15, Shantu Amin 15, James P Coleman 4, Yatrik M Shah 5, Jordan E Bisanz 2 16, Frank J Gonzalez 12, John P Vanden Heuvel 1 17, Gary D Wu 18, Babette S Zemel 3, Pieter C Dorrestein 7 8, Emily E Weinert 2 6, Andrew D Patterson 19 20 21

Journal: Nature

PubMed ID: 38326609

Doi: 10.1038/s41586-023-06990-w

Products & Services: Gene Synthesis

Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Authors: Xiaozhu Zhang, Briana Van Treeck, Connor A. Horton, Jeremy J. R. McIntyre, Sarah M. Palm, Justin L. Shumate & Kathleen Collins

Journal: Nat Biotechnol

PubMed ID: 38379101

Doi: 10.1038/s41587-024-02137-y

Products & Services: Plasmid DNA Preparation

Disordered regions mediate the interaction of p53 and MRE11

Authors: Sinem Usluer , Markus Galhuber , Yukti Khanna , Benjamin Bourgeois , Emil Spreitzer , Helene Michenthaler, Andreas Prokesch, Tobias Madl

Journal: Cell Research

PubMed ID: 38123020

Doi: 10.1016/j.bbamcr.2023.119654

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Biomimetic bacteria-derived nanoclusters enhance ferroptosis cancer immunotherapy through synergistic CRISPR-photothermo modulation

Authors: Xiuhua Pan , Jie Yang , Ruixin Kang , Jun Zhang , Zongwei Hu , Ning Yang , Zengyi Liu , Zengguang Jia , Xiawei Zhou , Qi Shen

Journal: Nano Today

Doi: 10.1016/j.nantod.2024.102213

Products & Services: CRISPR Services

Engineering recombinant replication-competent bluetongue viruses expressing reporter genes for and non-invasive studies

Authors: Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Alejandro Marín-López, Miguel Illescas-Amo, Germán Andrés, Eva Calvo-Pinilla, Gema Lorenzo, Piet A van Rijn, Javier Ortego, Aitor Nogales

Journal: Microbiol Spectr

PubMed ID: 38353566

Doi: 10.1128/spectrum.02493-23

Products & Services: Molecular Biology Reagents

Rapid Decline of SARS-CoV-2 Viral Load in Single vs Double-Dose (Short-Interval <6 Weeks) ChAdOx nCoV-19 Vaccinated Health-Care Workers

Authors: Arnab Ghosh, Poonam Kanta, Manisha Ramola, Ritin Mohindra, Kapil Goyal, Roop Kishore, Vikas Suri, P V M Lakshmi, Chanderkanta Chauhan, Manisha Sharma, Partha Rakshit, Kalaiarasan Ponnusamy, Tanzin Dikid, Mini P Singh

Journal: Curr Microbiol

PubMed ID: 38353761

Doi: 10.1007/s00284-023-03603-7

Products & Services: Serology SARS-Cov-2 detection kits

Site-Directed Mutagenesis of VvCYP76F14 (Cytochrome P450) Unveils Its Potential for Selection in Wine Grape Varieties Linked to the Development of Wine Bouquet

Authors: Bin Peng, Jianguo Ran, Yiyang Li, Meiling Tang, Huilin Xiao, Shengpeng Shi, Youzheng Ning, Adeeba Dark, Jin Li, Xueqiang Guan, Zhizhong Song

Journal: J Agric Food Chem

PubMed ID: 38334101

Doi: 10.1021/acs.jafc.3c09083

Products & Services: Gene Synthesis

Applying valency-based immuno-selection to generate broadly cross-reactive antibodies against influenza hemagglutinins

Authors: Daniëla Maria Hinke, Ane Marie Anderson, Kirankumar Katta, Marlene Fyrstenberg Laursen, Demo Yemane Tesfaye, Ina Charlotta Werninghaus, Davide Angeletti, Gunnveig Grødeland, Bjarne Bogen, Ranveig Braathen

Journal: Nat Commun

PubMed ID: 38346952

Doi: 10.1038/s41467-024-44889-w

Products & Services: Catalog Peptides