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Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
Authors: Shuai Jin, Zixu Zhu, Yunjia Li, Shouyue Zhang, Yijing Liu, Danyuan Li, Yuanqing Li, Yingfeng Luo, Zhiheng Cheng, Kevin Tianmeng Zhao, Qiang Gao, Guanglei Yang, Hongchao Li, Ronghong Liang, Rui Zhang, Jin-Long Qiu, Yong E Zhang, Jun-Jie Gogo Liu, Caixia Gao
Journal: Cell
PubMed ID: 41027434
Doi: doi.org/10.1016/j.cell.2025.09.004
Products & Services: Codon Optimization   PCR Cloning and Subcloning   
Neutrophil elastase-activatable ratiometric photoacoustic nanoprobes for imaging atherosclerotic plaque vulnerability
Authors: Hui Cao, Xin Meng, Yuan Ma, Zhe Li, Xinyu Xu, Jiaqi Fu, Qingpeng Zhang, Hanlin Wei, Peng Liang, Dingyou Lu, Jinyu Li, Baoli Yin, Shuangyan Huan, Xiao-Bing Zhang, Guosheng Song
Journal: Nature Communications
PubMed ID: 41173886
Doi: 10.1038/s41467-025-64633-2
Products & Services: Catalog Peptides   
TOPO-seq reveals DNA topology-induced off-target activity by Cas9 and base editors
Authors: Min Duan, Pan Gao, Yi-Zhou Zhang, Yu-Long Hu, Lei Zhou, Zhong-Chen Xu, Hou-Yuan Qiu, Xiao-Han Tong, Rui-Jin Ji, Xin-Lin Lei, Hao Yin, Cun-Lan Guo, Ying Zhang
Journal: Nature Chemical Biology
PubMed ID: 40175512
Doi: 10.1038/s41589-025-01867-7
Products & Services: Synthetic Guide RNA   
A motif preferred adenine base editor with minimal bystander and off-targets editing
Authors: Mengyu Shang, Yinuo Li, Qiuyu Cao, Jingxuan Ren, Yuqiang Zeng, Jinxin Wang, Rachel V. L. Gonzalez & Xiaohui Zhang
Journal: Nature Communications
PubMed ID: 41093849
Doi: 10.1038/s41467-025-64203-6
Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1
Authors: Behnaz Davoudinasab, Aleksey Raskovalov, Woojin Lee, Donggyun Kim, Heesoo Kim, Jordy Homing Lam, Gye Won Han, Vsevolod Katritch, Vadim Cherezov
Journal: Nature Communications
PubMed ID: 41062467
Doi: 10.1038/s41467-025-64002-z
A dirigent protein redirects extracellular terpenoid metabolism for defense against biotic challenges
Authors: Jia-Ling Lin, Wen-Kai Wu, Gui-Bin Nie, Jian-Xu Li, Xin Fang, Yin-Guo Sheng, Meng-Meng Wang, Qi-Yue Zheng, Xiao-Xiang Guo, Jia-Fa Huang, Li-Ying Ma, Ling-Jian Wang, Jia-Xin Liu, Shan-Shan Wang, Baofu Xu, Yiqun Gao, Yan Li, Dong Wang, Cathie Martin, Xiao-Ya Chen & Jin-Quan Huang
Journal: Nature Communications
PubMed ID: 41115945
Doi: 10.1038/s41467-025-64323-z
Products & Services: Protein Electrophoresis and Western   
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion
Authors: Giovanni Luchetti, Marin V. Miner, Rachael M. Peterson, William P. Scott, Praveen Krishnamoorthy, Eric M. Kofoed, Angel G. Jimenez, Hua Zhang, Man Wah Tan, Rohit Reja, Tommy K. Cheung, Elizabeth Skippington, Yuxin Liang, Christopher M. Rose, Nobuhiko Kayagaki, Kim Newton, Isabella Rauch & Vishva M. Dixit
Journal: Nature
PubMed ID: 41125892
Doi: 10.1038/s41586-025-09645-0
Signal-strapping as a protein-sequence search method for the discovery of metalloproteins
Authors: João Paulo L Franco Cairo, Thamy L R Corrêa, Wendy A Offen, Alison K Nairn, Julia Walton, Sean T Sweeney, Gideon J Davies, Paul H Walton
Journal: Nature Communications
PubMed ID: 41115942
Doi: 10.1038/s41467-025-64309-x
Products & Services: Gene Synthesis   PCR Cloning and Subcloning   
Integration of humanized ROBO1 CAR in PD-1 locus in natural killer cells delivers synergistic tumor-killing effect against nonsmall cell lung cancer
Authors: Jia-Hao Tao, Jun Zhang, Chun-Yan Tang, Jia-Xi Duan, Wen-Jing Zhong, Chen-Yu Zhang, Yu-Biao Liu, Jin Ling, Hua-Shun Li, Yong Zhou, Cha-Xiang Guan
Journal: Cancer gene therapy
PubMed ID: 40913086
Doi: 10.1038/s41417-025-00957-x
Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)   
Reinforced plant-derived lipid nanoparticles for oral precise epigenome editing in colonic diseases
Authors: Qiang Gao, Yunxia Gao, Yingui Cao, Haiting Xu, Ya Ma, Menghang Zu, Qiang Yang, Kun Yang, Zhenhua Zhu, Chao Liu, Xiaoxiao Shi, Rui L Reis, Subhas C Kundu, Shengyun Ma, Hesong Han, Bo Xiao
Journal: SCIENCE ADVANCES
PubMed ID: 41004579
Doi: 10.1126/sciadv.adw9275
Products & Services: Catalog Gene Editing   
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