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Isofagomine inhibits multiple TcdB variants and protects mice from induced mortality

Authors: Ashleigh S Paparella, Isabella Brew, Huynh A Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C Tyler, Vern L Schramm

Journal: biorxiv

PubMed ID: 37781587

Doi: 10.1101/2023.09.19.558375

Products & Services: Combinatorial DNA Libraries

A temperature dependent pilin promoter for production of thermostable enzymes in Thermus thermophilus

Authors: Lennart Kirchner, Volker Müller, Beate Averhoff

Journal: Microb Cell Fact

PubMed ID: 37726752

Doi: 10.1186/s12934-023-02192-1

Products & Services: Codon Optimization

A Proteorhodopsin-Related Photosensor Expands the Repertoire of Structural Motifs Employed by Sensory Rhodopsins

Authors: Maryam Saliminasab, Yoichi Yamazaki, Alyssa Palmateer, Andrew Harris, Luiz Schubert, Pit Langner, Joachim Heberle, Ana-Nicoleta Bondar, Leonid S Brown

Journal: J Phys Chem B

PubMed ID: 37694950

Doi: 10.1021/acs.jpcb.3c04032

Products & Services: Mutant Libraries Mutagenesis Services Gene Synthesis

Antibacterial Fusobacterium nucleatum-Mimicking Nanomedicine to Selectively Eliminate Tumor-Colonized Bacteria and Enhance Immunotherapy Against Colorectal Cancer

Authors: Linfu Chen , Rui Zhao , Jingjing Shen , Nanhui Liu , Zixuan Zheng , Yu Miao , Jiafei Zhu , Lin Zhang , Yingyao Wang , Huapan Fang , Jun Zhou , Maoyi Li , Yang Yang , Zhuang Liu , Qian Chen

Journal: Adv Mater .

PubMed ID: 37722134

Doi: 10.1002/adma.202306281

Products & Services: Gene Synthesis

TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in tachyzoites and bradyzoites

Authors: Robert D Murphy, Cortni A Troublefield, Joy S Miracle, Lyndsay E A Young, Corey O Brizzee, Animesh Dhara, Ramon C Sun, Craig W Vander Kooi, Matthew S Gentry, Anthony P Sinai

Journal: biorxiv

PubMed ID: 37808860

Doi: 10.1101/2023.09.29.560185

Products & Services: Proteins, Expression, Isolation and Analysis

Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors

Authors: Matteo Righi, Isaac Gannon, Matthew Robson, Saket Srivastava, Evangelia Kokalaki, Thomas Grothier, Francesco Nannini, Christopher Allen, Yuchen V Bai, James Sillibourne, Shaun Cordoba, Simon Thomas, Martin Pule

Journal: Cancer Immunol Res

PubMed ID: 37352396

Doi: 10.1158/2326-6066.CIR-22-0640

Products & Services: Proteins, Expression, Isolation and Analysis

Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors

Authors: Nicholas D Clark, Christopher Pham, Kurni Kurniyati, Ching Wooen Sze, Laurynn Coleman, Qin Fu, Sheng Zhang, Michael G Malkowski, Chunhao Li

Journal: PLoS Pathog

PubMed ID: 37747935

Doi: 10.1371/journal.ppat.1011674

Products & Services: Molecular Biology Reagents

Ultrasound-Induced Microbubble Cavitation for Targeted Delivery of MiR-29b Mimic to Treat Cardiac Fibrosis

Authors: Rafey A Feroze, Jonathan Kopechek, Jianhui Zhu, Xucai Chen, Flordeliza S Villanueva