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Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening

Authors: Xing Li, Shiyu Sun, Wansong Zhang, Ziwei Liang, Yitong Fang, Tianhu Sun, Yong Wan, Xingcong Ma, Shuqun Zhang, Yang Xu, Ruilin Tian

Journal: Experimental & Clinical Cancer Research

PubMed ID: 38561797

Doi: 10.1186/s13046-024-03027-6

Products & Services: Recombinant Proteins

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation

Authors: Miko aj S abicki; Jiho Park; Rados aw P. Nowak; Shourya S. Roy Burman; Jesse Pellman; Charles Zou; Hlib Razumkov; Jeannie Carreiro; Simran Rastogi; Anna Goldstein; Marek M. Nagiec; Katherine A. Donovan; Jianwei Che; Moritz Hunkeler; Qixiang Geng; Chi-Lin Hsu; Megha Lakshminarayan; Chelsea Shu; Rebecca L. Zon; Zuzanna Kozicka; Paul M.C. Park; Jonathan M. Tsai; Hojong Yoon; Lyn H. Jones; Adam S. Sperling; Nathanael S. Gray; Eric S. Fischer; Benjamin L. Ebert

Journal: Molecular Cell

PubMed ID: 40845806

Doi: 10.1016/j.molcel.2025.07.019

Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning

Authors: Gorka Lasso; Michael Grodus; Estefania Valencia; Veronica DeJesus; Eliza Liang; Isabel Delwel; Rob H. Bortz; Dmitry Lupyan; Hanna Y. Ehrlich; Adrian A. Castellanos; Andrea Gazzo; Heather L. Wells; Supaporn Wacharapluesadee; Alexandre Tremeau-Bravard; Janine F.R. Seetahal; Tom Hughes; Jimmy Lee; Mei-Ho Lee; Anna R. Sjodin; Marike Geldenhuys; Marinda Mortlock; Isamara Navarrete-Macias; Kirsten Gilardi; Michael R. Willig; Alessandra F.D. Nava; Elisabeth H. Loh; Makda Asrat; Tierra Smiley-Evans; Walter S. Magesa; Sijali Zikankuba; David Wolking; Gerardo Suz n; Rafael Ojeda-Flores; Christine V.F. Carrington; Ariful Islam; Jonathan H. Epstein; Wanda Markotter; Christine K. Johnson; Tracey Goldstein; Barbara A. Han; Jonna A.K. Mazet; Rohit K. Jangra; Kartik Chandran; Simon J. Anthony

Journal: Cell Host & Microbe

PubMed ID: 39818205

Doi: 10.1016/j.chom.2024.12.016

Products & Services: Protein and Antibody Isolation

Virtual screening and evaluation of bioactive peptides from Haliotis discus hannai as potential HMGCR inhibitors for hyperlipidemia treatment

Authors: Kun Qiao; Lina Liu; Yihui Chen; Qiongmei Huang; Bei Chen; Jingna Wu; Wenmei Huang; Zhiyu Liu

Journal: Frontiers in nutrition

PubMed ID: 39811675

Doi: 10.3389/fnut.2024.1525768

Products & Services: Peptide Synthesis

Mammalian PIWI–piRNA–target complexes reveal features for broad and efficient target silencing

Authors: Zhiqing Li, Zhenzhen Li, Yuqi Zhang, Lunni Zhou, Qikui Xu, Lili Li, Lin Zeng, Junchao Xue, Huilin Niu, Jing Zhong, Qilu Yu, Dengfeng Li, Miao Gui, Yongping Huang, Shikui Tu, Zhao Zhang, Chun-Qing Song, Jianping Wu，En-Zhi Shen

Journal: Nat Struct Mol Biol

PubMed ID: 38658622

Doi: 10.1038/s41594-024-01287-6.

Products & Services: Protein and Antibody Isolation

Structural basis of exoribonucleasemediated mRNA transcription termination

Authors: Yuan Zeng, Hong-Wei Zhang, Xiao-Xian Wu, Yu Zhang

Journal: Nature

PubMed ID: 38538796

Doi: doi.org/10.1038/s41586-024-07240-3

Products & Services: Catalog Peptides

Tailored UPRE2 variants for dynamic gene regulation in yeast

Authors: Chufan Xiao, Xiufang Liu, Yuyang Pan, Yanling Li, Ling Qin, Zhibo Yan, Yunzi Feng, Mouming Zhao, Mingtao Huang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38687789

Doi: 10.1073/pnas.2315729121

Products & Services: Molecular Biology Reagents

Duration of antibody response to the receptor binding domain of SARS-CoV-2 in infected or vaccinated individuals - A one year retrospective cohort study

Authors: Martin Pasev, Angelina Trifonova, Andrey Velichkov, Velislava Terzieva

Journal: Int Immunopharmacol

PubMed ID: 38621337

Doi: 10.1016/j.intimp.2024.112084

Products & Services: Serology SARS-Cov-2 detection kits

A long-acting FGF21 attenuates metabolic dysfunction-associated steatohepatitis-related fibrosis by modulating NR4A1-mediated Ly6C phenotypic switch in macrophages

Authors: Yue Ji, Yiliang Duan, Yuanyuan Li, Qingzhou Lu, Dingkang Liu, Yifan Yang, Ruilong Chang, Jing Tian, Wenbing Yao, Jun Yin, Xiangdong Gao

Journal: Br J Pharmacol

PubMed ID: 38679486

Doi: 10.1111/bph.16378

Products & Services: Molecular Biology Reagents

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Authors: Sofie J Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M F Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher

Journal: Mol Metab

PubMed ID: 38631478

Doi: 10.1016/j.molmet.2024.101938

Products & Services: Molecular Biology Reagents