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Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter

Authors: Victor Hugo Pérez Carrillo, Margot Di Cesare, Dania Rose-Sperling, Waqas Javed, Hannes Neuweiler, Julien Marcoux, Cédric Orelle, Jean-Michel Jault, Ute A Hellmich

Journal: Nature Communications

PubMed ID: 41219214

Doi: 10.1038/s41467-025-65037-y.

A bispecific antibody targeting PD-L1/TNFR2 increases tumor targeting and enhances antitumor efficacy in colorectal cancer

Authors: Xiaozhen Kang, Peng Qian, Yifeng Han, Mengdi Wu, Yuxin Li, Chun Xu, Jiwu Wei

Journal: Journal for ImmunoTherapy of Cancer

PubMed ID: 41238220

Doi: https://doi.org/10.1136/jitc-2025-013001

Products & Services: Catalog Antibodies

Early CD4+ T-cell immune reconstitution as a biomarker for Epstein-Barr virus control following allogeneic transplantation

Authors: Kexin Lin, Wenwen Yang, Jiaxiu Yin, Jing Luo, Hao Zhou, Lanxiang Liu, Li Yang, Jie Luo, Lin Liu, Junli Mou

Journal: Blood research

PubMed ID: 41186900

Doi: 10.1007/s44313-025-00106-1

Products & Services: Molecular Biology Reagents

Double-stranded DNA deaminase DddAE1347A can increase the efficiency and targeting range of cytidine base editors

Authors: Yuqiang Qian, Fengjiao Hui, Wenchao Niu, Di Wang, Yang Hao, Qingying Meng, Siyu Ren, Deqiang Kong, Heng Gong, Jiayu Wu, Kexin Chen, Muna Alariqi, Junping Gao, Zhanjun Li, Shuangxia Jin

Journal: Genome Biology

PubMed ID: 41250247

Doi: 10.1186/s13059-025-03849-3

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1

Authors: Yu Hsuan Chen, Martin Esparza Sanchez, Ta I Hung, Jin Tang, Wenyan Xu, Jiekai Yin, Yinsheng Wang, Chia-En A Chang, Huimin Zhang, Junjie Chen, Linlin Zhao

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41259143

Doi: doi.org/10.1073/pnas.2509312122

Products & Services: Catalog Antibodies

Engineering Multicellular Inter-communication Systems Using a Synthetic Homodimer-inducible Kinase Receptor

Authors: Quan Zhang, Miao Zhang, Yao Zhang, Fenglin Wang, Jian-Hui Jiang

Journal: Angewandte Chemie (International ed. in English)

PubMed ID: 41267507

Doi: 10.1002/anie.202513254

Products & Services: PCR Cloning and Subcloning DNA Sequencing

SLC7A11-independent disulfidptosis induced by a two-pronged delivery strategy for bladder cancer chemotherapy and cisplatin-resistance reverse

Authors: Bin Zheng, Facai Zhang, Heng Wang, Wenyan Zuo, Dingyi Liu, Zhihan Wu, Zhenghong Liu, Haichang Li, Yang Liu, Yixuan Mou, Xiaowen Qin, Dahong Zhang, Pu Zhang, Qi Zhang

Journal: Materials today. Bio

PubMed ID: 41322137

Doi: 10.1016/j.mtbio.2025.102547

Products & Services: Protein and Antibody Isolation

Unveiling conformation-selective regulation of the norepinephrine transporter

Authors: Heng Zhang, Tianwei Zhang, Dingyan Wang, Antao Dai, Jianhang Mao, Qihui Chen, Tianyuan Du, Xue Lu, Yongxin Hao, Chao Zhang, Yu-Ling Yin, Wen Hu, Benxun Pan, Sanshan Jin, Mengting Jiang, Yuan Si, Qingning Yuan, Ming-Wei Wang, Mingyue Zheng, Zhen Wang, Dehua Yang, H Eric Xu, Yi Jiang

Journal: Cell

PubMed ID: 41138730

Doi: 10.1016/j.cell.2025.10.002

Products & Services: Protein and Antibody Isolation

A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes

Authors: Enzo Mameli, George-Rafael Samantsidis, Raghuvir Viswanatha, Hyeogsun Kwon, David R Hall, Matthew Butnaru, Yanhui Hu, Stephanie E Mohr, Norbert Perrimon, Ryan C Smith

Journal: Nature Communications

PubMed ID: 41285753

Doi: 10.1038/s41467-025-65304-y.

Products & Services: PCR Cloning and Subcloning

PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors

Authors: Andrew D Huber, Wenwei Lin, Young-Hwan Jung, Shyaron Poudel, Guangwei Yang, Jing Wu, Annalise G Carrigan, Vishwajeeth Pagala, Wei Wang, Yingxue Fu, Zuo-Fei Yuan, Stephanie D Byrum, Ka Yang, Rebecca R Florke Gee, Elizabeth D Arnold, Allister J Loughran, Jingheng Wang, Shondra M Pruett-Miller, Junmin Peng, Taosheng Chen

Journal: Nature Communications

PubMed ID: 41198675

Doi: 10.1038/s41467-025-64773-5.

Products & Services: Bacterial Expression