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A Circulating GPNMB-Based Multimodal Model Integrates Tumor−Immune Crosstalk to Predict Immunotherapy Response in Esophageal Cancer

Authors: Liang Zhu, Xiaoyuan Wang, Guoyu Cheng, Yancheng Lai, Lan Lan, Zhenghao Dong, Zhixuan You, Xinjie Chen, Ziyi He, Xinyi Xiao, Lingxuan Zhu, Rucheng Liu, Li Zhang, Shaosen Zhang, Dongxin Lin, Chen Wu, Jiang Chang

Journal: Cancer discovery

PubMed ID: 41747244

Doi: 10.1158/2159-8290.CD-25-1907

Products & Services: Recombinant Proteins

Modulating ER-mitochondrial crosstalk to revitalize implant osseointegration in diabetes through an injectable hydrogel platform

Authors: Hao Wang, Ziqi Qin, Beilei Liu, Chen Li, Yifeng Ruan, Yifei Shen, Hao Li, Irene Shuping Zhao, Xueqi Gan

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2026.177208

Products & Services: Custom DNA/RNA Oligos

Efficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition

Authors: Junjie Zhu, Lin Ding, Kai-Ming Liu, Xingyu Zhu, Jifang Li, Buer Ha, Bao-Qing Gao, Xujiao Zhou, Chengfang Liu, Jia Wei, Shuangyu Ma, Wenchao Xu, Lingyun Kong, Jing Wu, Xiaodun Mou, Bei Yang, Lijie Wang, Jiaxu Hong, Li Yang & Jia Chen

Journal: Nature Biotechnology

Doi: 10.1038/s41587-026-03227-9

Products & Services: Gene Synthesis Synthetic Guide RNA

Ultrasensitive CRISPR-based biosensing platform for early diagnosis of Alzheimer's disease by simultaneous detection of plasma Aβ and hyperphosphorylated tau

Authors: Liding Zhang, Xuewei Du, Changwen Yang, Hui Gong, Min Zhang, Ying Han, Haiming Luo

Journal: SENSORS AND ACTUATORS B-CHEMICAL

Doi: 10.1016/j.snb.2025.138239

Products & Services: Catalog Antibodies

Intelligent Metal-Integrated Hydrogels Orchestrate Pyroptosis and cGAS-STING for Potentiated Treatment of Colorectal Cancer Peritoneal Metastasis

Authors: Lin-Zhu Zhang, Liang-Wei Si, Hui Xu, Fei Xiong, Juan Qin, Hai-Dong Zhu

Journal: Journal of controlled release

PubMed ID: 42456978

Doi: 10.1016/j.jconrel.2026.115184

Products & Services: Protein Electrophoresis and Western

Surface charge engineering shields extracellular vesicles from plasma protein corona to enable systemic extrahepatic targeting

Authors: Taotao Tang, Mengyun Wang, Xiaowei Xu, Jin Wang, Yan Wang, Fangzhou Wang, Deping Wu, Yilin Zhang, Shuangshuang Liu, Lingting Kong, Zhiqing Chen, Feng Chen, Yi Wen, Bin Wang, Junjia Wang, Bicheng Liu, Linli Lv

Journal: Materials today. Bio

PubMed ID: 42494417

Doi: 10.1016/j.mtbio.2026.103471

Products & Services: Protein Electrophoresis and Western

Beyond CAT, BSD, and URA: SUL, A novel selectable marker for Cyanidioschyzon merolae

Authors: Yissell Borges-Rodríguez, Martha R Stark, Elise Kerckhofs, Julie Mueller, Kyle J Lauersen, Daniel Schubert, Stephen D Rader

Journal: New biotechnology

PubMed ID: 41643937

Doi: 10.1016/j.nbt.2026.01.012

Products & Services: Gene Synthesis

Surface immune signaling unlocks NLR activation through mRNA alternative splicing

Authors: Chuyun Gao, Xi Meng, Xianchu Chen, Leiyun Yang, Tarhan Ibrahim, AmirAli Toghani, Enoch Lok Him Yuen, Nick Eilmann, Freddie King, Kangping Li, Luyao Wang, Biying Sun, Yuanchao Wang, Tolga Osman Bozkurt, Suomeng Dong

Journal: Science

PubMed ID: 42391383

Doi: 10.1126/science.adx9929

Products & Services: Gene Fragments Catalog Peptides

Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy

Authors: Lin Li, Xiu-Li Yan, Hao-Yang Wang, Hang-Yu Zhou, Yu-Yan Li, Wenlong Ma, Jian Li, Rong-Rong Zhang, Lu Lv, Xing-Yao Huang, Hao Du, Tian-Shu Cao, Qing Ye, Hui Zhao, Yan Fu, Byung-Ho Kang, Qiang Ding, Aiping Wu, Yi-Jiao Huang, Cheng-Feng Qin

Journal: Cell

PubMed ID: 42476130

Doi: 10.1016/j.cell.2026.06.031

Products & Services: Gene Synthesis

An additional site mutation in STING/MITA gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy

Authors: Fang-Xu Li, Sheng Liu, Zhi-Dong Zhang, Xin Shuai, Bi-Kun Xiao, Jia Yang, Defen Lu, Dandan Lin, Guijun Shang, Bo Zhong

Journal: Cell Insight

PubMed ID: 41626295

Doi: 10.1016/j.cellin.2026.100298

Products & Services: Peptide Synthesis