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Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinoma

Authors: Yan Huang, Shaoli Liu, Xiaoju Zhang, Bingxu Zhang, Feng Shi, Jia Zhang, Shuaibo Shao, Hongya Han, Xiaoyun Ma, Jing Xie, Jianqi Zhang, Hongxiaoying Yu, Yongchao Zhao, Jiazheng Jin, Dong Xu, Liang Liu, Jianing Wang, Yu Tan, Kelu Xu, Lushuai Jin, Quanjun Du, Yifeng Geng, Andong Liu, Wei Xu

Journal: Nature Communications

PubMed ID: 41397962

Doi: 10.1038/s41467-025-66087-y

Products & Services: Custom Vector Construction

Molecular insights into ligand recognition and signaling of OXGR1

Authors: Aijun Liu, Yezhou Liu, Yuanzhengyang Long, Richard D Ye

Journal: Nature Communications

PubMed ID: 41413034

Doi: 10.1038/s41467-025-67101-z

Products & Services: Protein and Antibody Isolation

Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection

Authors: Rui Chao, Yexin Wang, Zhan Liu, Tianhao Wan, Yi Mao, Xinru Xie, Lei Sun, Weifeng Xu, Xuzhuo Chen, Shanyong Zhang

Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PubMed ID: PMC12488209

Doi: 10.3892/ijmm.2025.5647

Products & Services: Protein and Antibody Isolation

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender

Authors: Yan Huang, Biao Hu, Ya Liu, Ling-Qi Xie, Yu Dai, Yu-Ze An, Xin-Yi Peng, Ya-Lun Cheng, Yi-Fan Guo, Wei-Hong Kuang, Yao Xiao, Xin Chen, Yong-Jun Zheng, Gen-Qing Xie, Jian-Ping Wang, Hui Peng, Xiang-Hang Luo

Journal: Cell metabolism

PubMed ID: 41344322

Doi: doi.org/10.1016/j.cmet.2025.11.002

Products & Services: Nucleic Acid Purification

RING- Type E3 Ligase OsRFPH2- 6 Ubiquitinates Nuclear Factor Y Subunit OsNF- YA1 to Suppress Rice Immunity

Authors: Yan Bi, Leeza Tariq, Hui Wang, Yuqing Yan, Dayong Li, Fengming Song

Journal: Molecular plant pathology

PubMed ID: 41424058

Doi: 10.1111/mpp.70193

Products & Services: Catalog Antibodies

Nuclear effects play an important role in determining codon usage-dependent human gene expression

Authors: Renu Garg, Pancheng Xie, Jiabin Duan, Huan Liu, Yi Liu

Journal: Nature Communications

PubMed ID: 41339630

Doi: 10.1038/s41467-025-65907-5

Products & Services: Gene Synthesis

Structural basis of microtubule-mediated signal transduction

Authors: Sung Ryul Choi, Thorsten B Blum, Matteo Giono, Bibhas Roy, Ioannis Vakonakis, Dominic Schmid, Nicole Oelgarth, Apisha Ranganathan, Alvar D Gossert, G V Shivashankar, Alfred Zippelius, Michel O Steinmetz

Journal: Cell

PubMed ID: 41365297

Doi: 10.1016/j.cell.2025.11.011

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors

Authors: Michael Launspach, Julia Macos, Shoaib Afzal, Janik Hohmann, Marc L Appis, Maximilian Pilgram, Stefanie Beez, Emily Ohlendorf, Casper F T van der Ven, Chahrazad Lachiheb, Karin Töws, Lena Andersch, Marvin Jens, Felix Zirngibl, Jonas Kath, Maria Stecklum, Elias Rodriguez-Fos, Kathleen Anders, Dimitrios L Wagner, Anton G Henssen, Ralf Kühn, Angelika Eggert, Annette Künkele

Journal: Nature Communications

PubMed ID: 41366257

Doi: 10.1038/s41467-025-67328-w

A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Authors: Zilong Wang, Seokjung Cheong, Jose Henrique Pereira, Weixi Hu, Yifan Guo, Andy DeGiovanni, Guangxu Lan, Jinho Kim, Robert W Haushalter, Taek Soon Lee, Paul D Adams, Jay D Keasling

Journal: Nature Communications

PubMed ID: 41365852

Doi: 10.1038/s41467-025-65946-y

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions

Authors: Joshua Tomkins, Lucy V Edwardes, Sarah V Faull, Matthew Peach, Peter J Gillespie, Vera Leber, Anna Schmidt, Halil Bounoua, Nicholas Sim, Rosa Camarillo, J Julian Blow, Alexis R Barr, Anna Barnard, Christian Speck

Journal: Nature Communications

PubMed ID: 41365879

Doi: 10.1038/s41467-025-67073-0