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The Human T-cell Leukemia Virus capsid protein is a potential drug target

Authors: Ruijie Yu, Prabhjeet Phalora, Nan Li, Till Böcking, David Anthony Jacques

Journal: Nature Communications

PubMed ID: 41345105

Doi: 10.1038/s41467-025-65899-2

Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors

Authors: Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu

Journal: Advanced Science

PubMed ID: 41388583

Doi: 10.1002/advs.202512342

Products & Services: Peptide Synthesis

Protein-nucleic acid language model-assisted design of precise and compact adenine base editor

Authors: Jingxuan Ren, Jiawei Yao, Qiuyu Cao, Yinuo Li, Yang Li, Ziyi Zhang, Xiyu Ge, Shengfang Wang, Yang Zhang, Xiaogang Wang, Xiaohui Zhang

Journal: Nature Communications

PubMed ID: 41390734

Doi: 10.1038/s41467-025-65311-z

Products & Services: Synthetic Guide RNA

Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinoma

Authors: Yan Huang, Shaoli Liu, Xiaoju Zhang, Bingxu Zhang, Feng Shi, Jia Zhang, Shuaibo Shao, Hongya Han, Xiaoyun Ma, Jing Xie, Jianqi Zhang, Hongxiaoying Yu, Yongchao Zhao, Jiazheng Jin, Dong Xu, Liang Liu, Jianing Wang, Yu Tan, Kelu Xu, Lushuai Jin, Quanjun Du, Yifeng Geng, Andong Liu, Wei Xu

Journal: Nature Communications

PubMed ID: 41397962

Doi: 10.1038/s41467-025-66087-y

Products & Services: Custom Vector Construction

Molecular insights into ligand recognition and signaling of OXGR1

Authors: Aijun Liu, Yezhou Liu, Yuanzhengyang Long, Richard D Ye

Journal: Nature Communications

PubMed ID: 41413034

Doi: 10.1038/s41467-025-67101-z

Products & Services: Protein and Antibody Isolation

Nuclear effects play an important role in determining codon usage-dependent human gene expression

Authors: Renu Garg, Pancheng Xie, Jiabin Duan, Huan Liu, Yi Liu

Journal: Nature Communications

PubMed ID: 41339630

Doi: 10.1038/s41467-025-65907-5

Products & Services: Gene Synthesis

Structural basis of microtubule-mediated signal transduction

Authors: Sung Ryul Choi, Thorsten B Blum, Matteo Giono, Bibhas Roy, Ioannis Vakonakis, Dominic Schmid, Nicole Oelgarth, Apisha Ranganathan, Alvar D Gossert, G V Shivashankar, Alfred Zippelius, Michel O Steinmetz

Journal: Cell

PubMed ID: 41365297

Doi: 10.1016/j.cell.2025.11.011

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors

Authors: Michael Launspach, Julia Macos, Shoaib Afzal, Janik Hohmann, Marc L Appis, Maximilian Pilgram, Stefanie Beez, Emily Ohlendorf, Casper F T van der Ven, Chahrazad Lachiheb, Karin Töws, Lena Andersch, Marvin Jens, Felix Zirngibl, Jonas Kath, Maria Stecklum, Elias Rodriguez-Fos, Kathleen Anders, Dimitrios L Wagner, Anton G Henssen, Ralf Kühn, Angelika Eggert, Annette Künkele

Journal: Nature Communications

PubMed ID: 41366257

Doi: 10.1038/s41467-025-67328-w

A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Authors: Zilong Wang, Seokjung Cheong, Jose Henrique Pereira, Weixi Hu, Yifan Guo, Andy DeGiovanni, Guangxu Lan, Jinho Kim, Robert W Haushalter, Taek Soon Lee, Paul D Adams, Jay D Keasling

Journal: Nature Communications

PubMed ID: 41365852

Doi: 10.1038/s41467-025-65946-y

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions

Authors: Joshua Tomkins, Lucy V Edwardes, Sarah V Faull, Matthew Peach, Peter J Gillespie, Vera Leber, Anna Schmidt, Halil Bounoua, Nicholas Sim, Rosa Camarillo, J Julian Blow, Alexis R Barr, Anna Barnard, Christian Speck

Journal: Nature Communications

PubMed ID: 41365879

Doi: 10.1038/s41467-025-67073-0