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Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity

Authors: Kristen C Vogt , Pedro C Silberman , Qianqian Lin , James E Han , Amy Laflin , Hendryck A Gellineau , Daniel A Heller , David A Scheinberg

Journal: SCIENCE ADVANCES

PubMed ID: 39841845

Doi: 10.1126/sciadv.ads3403

Products & Services: Gene Synthesis

Developing orthogonal fluorescent RNAs for photoactive dual-color imaging of RNAs in live cells

Authors: Peng Yin , Chunzheng Huang , Li Zhang , Zhenzhen Li , Caijun Zhong , Shi Kuang , Chunyang Lei , Yan Huang , Zhou Nie

Journal: Angew Chem Int Ed Engl

PubMed ID: 39801450

Doi: 10.1002/anie.202424060

Products & Services: Plasmid DNA Preparation

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing

Authors: Yongliang Tong , Runqiu Chen , Xinrong Lu , Cuiying Chen , Guiqin Sun , Xiaolu Yu , Shaoxian Lyu , Meiqing Feng , Yiru Long , Likun Gong , Li Chen

Journal: Int J Biol Macromol

PubMed ID: 39824395

Doi: 10.1016/j.ijbiomac.2025.139953

Products & Services: Gene Synthesis

Restoring tumor antigenicity activates the “bystander” T cell immune cycle

Authors: Yifan Yang , Qiumin Yu , Haoyu Zhang , Yuchen Liu , Hexuan Wang , Ningyi Yang , Yulian Shi , Wanli Zhang , Zijie Wu , Shitong Huang , Wenbin Xie , Ran Duan , Qiuli Mao , Xupeiyao Shi , Zheng Gao , Xiaoning Wang , Hanlin Guo , Lingxiao Chen , Yi Han , Ximing Li , Liyuan Chen , Siqi Tang , Ying Fan , Wenbing Yao , Hong Tian , Xiangdong Gao

Journal: J Control Release

PubMed ID: 39894265

Doi: 10.1016/j.jconrel.2025.01.094

Products & Services: Gene Synthesis

Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy

Authors: Nailin Yang , Shumin Sun , Jiachen Xu , Fei Gong, Huali Lei , Yu Hao , Zifan Pei , Chenya Wang , Qiao Yu , Jihu Nie , Nan Jiang , Caifang Ni , Liang Cheng

Journal: Adv Mater

PubMed ID: 10.1002/adma.202414929

Doi: 10.1002/adma.202414929

Products & Services: Protein and Antibody Isolation

Computational design, expression, and characterization of a Plasmodium falciparum multi-epitope, multi-stage vaccine candidate (PfCTMAG)

Authors: Joan A Chick, Nadege N Abongdia, Robert A Shey, Tobias O Apinjoh

Journal: Heliyon

PubMed ID: 39906795

Doi: 10.1016/j.heliyon.2025.e42014

Products & Services: Bacterial Expression

Structural dynamics of calcium and integrin-binding protein 2 (CIB2) reveal uncommon flexibility and heterogeneous calcium and magnesium loading

Authors: Gabriele Olivieri, Giuditta Dal Cortivo, Rebecca Del Conte, Serena Zanzoni, Valerio Marino, Daniele Dell'Orco, Francesca Cantini

Journal: International Journal of Biological Macromolecules

PubMed ID: 39586446

Doi: doi.org/10.1016/j.ijbiomac.2024.138003

Products & Services: Peptide Synthesis

Interplay between the Xer recombination system and the dissemination of antibioresistance in Acinetobacter baumannii

Authors: Corentin Blanchais, Carine Pages, Manuel Campos, Kenza Boubekeur, Rachel Contarin, Mathias Orlando, Patricia Siguier, Maria-Halima Laaberki, François Cornet, Xavier Charpentier, Philippe Rousseau

Journal: Nucleic Acids Research

PubMed ID: 39777461

Doi: 10.1093/nar/gkae1255

Products & Services: Gene Synthesis

Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity

Authors: Gage M. J. Fairlie, Kha M. Nguyen, Sung-Eun Nam, Alexandria L. Shaw, Matthew A. H. Parson, Hannah R. Shariati, Xinyin Wang, Meredith L. Jenkins, Michael Gong, John E. Burke & Calvin K. Yip

Journal: Nature Communications

PubMed ID: 39779760

Doi: 10.1038/s41467-025-55828-8

Products & Services: Protein and Antibody Isolation

Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection

Authors: Zhao-Shan Chen, Hsiang-Chi Huang, Xiangkun Wang, Karin Schön, Yane Jia, Michael Lebens, Danica F. Besavilla, Janarthan R. Murti, Yanhong Ji, Aishe A. Sarshad, Guohua Deng, Qiyun Zhu & Davide Angeletti

Journal: Nature Communications

PubMed ID: 39788944

Doi: 10.1038/s41467-024-55193-y

Products & Services: Catalog Antibodies