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Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinoma

Authors: Yan Huang, Shaoli Liu, Xiaoju Zhang, Bingxu Zhang, Feng Shi, Jia Zhang, Shuaibo Shao, Hongya Han, Xiaoyun Ma, Jing Xie, Jianqi Zhang, Hongxiaoying Yu, Yongchao Zhao, Jiazheng Jin, Dong Xu, Liang Liu, Jianing Wang, Yu Tan, Kelu Xu, Lushuai Jin, Quanjun Du, Yifeng Geng, Andong Liu, Wei Xu

Journal: Nature Communications

PubMed ID: 41397962

Doi: 10.1038/s41467-025-66087-y

Products & Services: Custom Vector Construction

Protein-nucleic acid language model-assisted design of precise and compact adenine base editor

Authors: Jingxuan Ren, Jiawei Yao, Qiuyu Cao, Yinuo Li, Yang Li, Ziyi Zhang, Xiyu Ge, Shengfang Wang, Yang Zhang, Xiaogang Wang, Xiaohui Zhang

Journal: Nature Communications

PubMed ID: 41390734

Doi: 10.1038/s41467-025-65311-z

Products & Services: Synthetic Guide RNA

Molecular insights into ligand recognition and signaling of OXGR1

Authors: Aijun Liu, Yezhou Liu, Yuanzhengyang Long, Richard D Ye

Journal: Nature Communications

PubMed ID: 41413034

Doi: 10.1038/s41467-025-67101-z

Products & Services: Protein and Antibody Isolation

The Human T-cell Leukemia Virus capsid protein is a potential drug target

Authors: Ruijie Yu, Prabhjeet Phalora, Nan Li, Till Böcking, David Anthony Jacques

Journal: Nature Communications

PubMed ID: 41345105

Doi: 10.1038/s41467-025-65899-2

Supramolecular lipid nanoparticle reprograms tumor microenvironment by cucurbit[7]uril-based host–guest recognition for STING-activating cancer immunotherapy

Authors: Yunxuan Feng, Yuan Yu, Xinyang Yu, Mengyao Li, Jiaqi Lei, Yongcan Li, Zhida Liu, Shaolong Qi, Guocan Yu

Journal: Materials Today

Doi: doi.org/10.1016/j.mattod.2025.11.029

Products & Services: Protein Electrophoresis and Western

OMP16-targeting monoclonal antibodies H4 and E6 reveal essential linear epitopes for Brucella immunoprotection

Authors: Yunyi Zhai, Kaihui Sun, Ye Yuan, Xiaofang Liu, Gaowa Wudong, Yuanhao Yang, Shuan Qu, Yaxin Li, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang

Journal: International Journal of Biological Macromolecules

PubMed ID: 41448303

Doi: 10.1016/j.ijbiomac.2025.149881

Products & Services: Bacterial Expression Mutagenesis Services Peptide Synthesis

Study on the phosphorylation of NAD+-specific isocitrate dehydrogenase in the pathogenic bacteria Stenotrophomonas maltophilia and Xanthomonas sacchari

Authors: Qian Tian, Yongmei Zhang, Chunxu Pan, Linxiao Wang, Na Qin, Zhen Jiang, Chenxi Li, Zhengyu Cao, Guoping Zhu, Peng Wang

Journal: Journal of enzyme inhibition and medicinal chemistry

PubMed ID: 41395810

Doi: 10.1080/14756366.2025.2593798

Products & Services: Gene Synthesis Codon Optimization

Induced Proprioceptor and Low-Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

Authors: Amy J Hulme, Rocio K Finol-Urdaneta, Jeffrey R McArthur, Nicholas R Marzano, Simon Maksour, Amarinder Thind, Yang Guo, Dominic Kaul, Marnie Maddock, Oliver Friedrich, Boris Martinac, David J Adams, Mirella Dottori

Journal: Advanced Science

PubMed ID: 41364594

Doi: 10.1002/advs.202512413

Products & Services: Lentivirus Packaging

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors

Authors: Michael Launspach, Julia Macos, Shoaib Afzal, Janik Hohmann, Marc L Appis, Maximilian Pilgram, Stefanie Beez, Emily Ohlendorf, Casper F T van der Ven, Chahrazad Lachiheb, Karin Töws, Lena Andersch, Marvin Jens, Felix Zirngibl, Jonas Kath, Maria Stecklum, Elias Rodriguez-Fos, Kathleen Anders, Dimitrios L Wagner, Anton G Henssen, Ralf Kühn, Angelika Eggert, Annette Künkele

Journal: Nature Communications

PubMed ID: 41366257

Doi: 10.1038/s41467-025-67328-w

Nuclear effects play an important role in determining codon usage-dependent human gene expression

Authors: Renu Garg, Pancheng Xie, Jiabin Duan, Huan Liu, Yi Liu

Journal: Nature Communications

PubMed ID: 41339630

Doi: 10.1038/s41467-025-65907-5

Products & Services: Gene Synthesis