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Microbiota-induced T cell plasticity enables immune-mediated tumour control

Authors: Tariq A Najar, Yuan Hao, Yuhan Hao, Gabriela Romero-Meza, Alexandra Dolynuk, Emma Almo, Dan R Littman

Journal: Nature

PubMed ID: 41535459

Doi: 10.1038/s41586-025-09913-z

Products & Services: Codon Optimization

Stress controls heterochromatin inheritance via histone H3 ubiquitylation

Authors: Bharat Bhatt, Yi Wei, Ashis Kumar Pradhan, Jothy Dhakshnamoorthy, Martin Zofall, Hua Xiao, Drisya Vijayakumari, Shweta Jain, Hernan Diego Folco, Hongyun Qi, David A Ball, Tatiana S Karpova, David Wheeler, Jiemin Wong, Shiv I S Grewal

Journal: Nature

PubMed ID: 41501458

Doi: 10.1038/s41586-025-09899-8

Products & Services: Protein and Antibody Isolation

Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease

Authors: Sarah N Zvornicanin, Ala M Shaqra, Julia Flynn, Lauren E Intravaia, Heidi Carias Martinez, Weiping Jia, Devendra Kumar Gupta, Stephanie Moquin, Dustin Dovala, Daniel N Bolon, Brian A Kelch, Celia A Schiffer, Nese Kurt Yilmaz

Journal: SCIENCE ADVANCES

PubMed ID: 41544157

Doi: 10.1126/sciadv.aeb0769

Products & Services: Molecular Biology Reagents

TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength

Authors: Martina Spiga, Alessia Potenza, Zulma Magnani, Stefano Beretta, Barbara Camisa, Laura Conte, Alessia Airaghi, Neda Mohammadi, Laura Perani, Claudio Doglioni, Maurilio Ponzoni, Francesca Sanvito, Chiara Balestrieri, Lucia Sergi Sergi, Oronza A Botrugno, Giulio Giovannoni, Giovanni Tonon, Danilo Abbati, Chiara Iozzi, Maximilian Reichert, Hana Algul, Arianna Pocaterra, Martina Fiumara, Samuele Ferrari, Alessia Ugolini, Alice Grometto, Giulia Di Lullo, Giovanni Sitia, Giulio Belfiori, Maria Pia Protti, Renato Ostuni, Anna Mondino, Michele Reni, Stefano Crippa, Massimo Falconi, Luigi Naldini, Eliana Ruggiero, Chiara Bonini

Journal: Nature Communications

PubMed ID: 41507193

Doi: 10.1038/s41467-025-67263-w

Products & Services: Peptide Synthesis

Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity

Authors: Pierce Longmire, Sebastian Zeltzer, Kristen Zarrella, Olivia Daigle, Marek Svoboda, Justin M Reitsma, Scott S Terhune, Carly Bobak, Giovanni Bosco, Felicia Goodrum

Journal: Nucleic Acids Research

PubMed ID: 41533576

Doi: 10.1093/nar/gkaf1445

Products & Services: Protein Electrophoresis and Western

FLIPs: Genetically encoded molecular biosensors for functional imaging of cell signaling by linear dichroism microscopy

Authors: Paul Miclea, Vendula Nagy-Marková, Robin Van den Eynde, Wim Vandenberg, Alina Sakhi, Alexey Bondar, Jitka Myšková, Peter Dedecker, Josef Lazar

Journal: SCIENCE ADVANCES

PubMed ID: 41544164

Doi: 10.1126/sciadv.adz5662

Products & Services: Gene Synthesis

Arboviruses manipulate rice’s volatile emissions, protecting insect vectors from natural enemies in the field

Authors: Qing Liu, Qian Wang, Qiong Li, Weiran Wang, Qi Li, Ziyuan Peng, Yuling Jiao, Feng Cui, Ian T Baldwin, Xiaoming Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 41499511

Doi: 10.1126/sciadv.aeb5215

Products & Services: Monoclonal Antibody Services

Optimally engineered HLA/peptide-specific CAR-T cells outperform TCR-T cells to eradicate solid tumors

Authors: Corinne E Decker, Jacqueline Idun, Katja Mohrs, Thomas Craig Meagher, Iryna Petriv, Jonathon Golas, Robert Salzler, Timothy Helms, Dharani Ajithdoss, Suhasini Avvaru, Jiaxi Wu, Tong Zhang, Eric Smith, Gavin Thurston, John C Lin, Jessica R Kirshner, David J DiLillo

Journal: SCIENCE ADVANCES

PubMed ID: 41564177

Doi: 10.1126/sciadv.adx9371

Products & Services: Gene Synthesis

Protection against lethal canine distemper virus infection by a dual epitope-targeting synthetic antibody

Authors: Melanie Scherer, Nadia Djabeur, Oliver Siering, Jean-Marc Jeckelmann, Marianne Wyss, Marina Cresci, Morgane Di Palma Subran, Rainer Riedl, Patrick Chames, Christian K Pfaller, Bevan Sawatsky, Dimitrios Fotiadis, Philippe Plattet

Journal: Nature Communications

PubMed ID: 41501035

Doi: 10.1038/s41467-025-67600-z

Products & Services: Monoclonal Antibody Services

Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation

Authors: Jun Nagai, Madeline M Hastings, Airi Nishida, Sreyashi Majumdar, Kendall Zaleski, Sofia A Marshall, Junrui Lin, Mira A S Saliman, Yumi Tani, Yamato Murakami, Chunli Feng, Alexander Perniss, Caitlin Wong, Lora G Bankova, Asuka Inoue, Nora A Barrett, Joshua A Boyce

Journal: Cell Reports

PubMed ID: 41422505

Doi: 10.1016/j.celrep.2025.116758

Products & Services: Custom Vector Construction