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页码: 122/5365 每页显示数量

Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1

Authors: Seow Theng Ong, Young-Woo Nam, Joshua A Nasburg, Alena Ramanishka, Xuan Rui Ng, Zhong Zhuang, Stephanie Shee Min Goay, Hai M Nguyen, Latika Singh, Vikrant Singh, Alicia Rivera, M Elaine Eyster, Yang Xu, Seth L Alper, Heike Wulff, Miao Zhang, K George Chandy

Journal: Proc Natl Acad Sci U S A

PubMed ID: 40294255

Doi: 10.1073/pnas.2425494122

Products & Services: Molecular Biology Tools

TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis

Authors: Yongyun Chang, Keyu Kong, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Jingwei Zhang, Yansong Qi, Yongsheng Xu, An Qin, Zanjing Zhai, Huiwu Li

Journal: International journal of biological sciences

PubMed ID: 40520017

Doi: 10.7150/ijbs.108832

Products & Services: Protein and Antibody Isolation

DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway

Authors: Chunyang Cai, Chufeng Gu, Chunren Meng, Yujie Wang, Qingquan Wei, Shuai He, Dongwei Lai, Xingyun Wang, Tengfei Wang, Qinghua Qiu

Journal: Clinical epigenetics

PubMed ID: 40380281

Doi: 10.1186/s13148-025-01874-4

Products & Services: Protein and Antibody Isolation

Mechanistic insights into the stimulation of the histone H3K9 methyltransferase Clr4 by proximal H3K14 ubiquitination

Authors: Yunxiang Du , Maoshen Sun , Zhengqing Li , Xiangwei Wu , Qian Qu , Huasong Ai , Lei Liu

Journal: SCIENCE ADVANCES

PubMed ID: 40446033

Doi: 10.1126/sciadv.adu1864

Products & Services: Gene Synthesis

CRISPR-Based Environmental Biosurveillance Assisted via Artificial Intelligence Design of Guide-RNAs

Authors: Benjamín Durán-Vinet, Jo-Ann L. Stanton, Gert-Jan Jeunen, Ulla von Ammon, Jackson Treece, Xavier Pochon, Anastasija Zaiko, Neil J. Gemmell

Journal: Environmental DNA

Doi: doi.org/10.1002/edn3.70105

Products & Services: Gene Synthesis Plasmid DNA Preparation Custom DNA/RNA Oligos Molecular Biology Reagents

A basigin antibody modulates MCTs to impact tumor metabolism and immunity

Authors: Heng Zhang, Xuemei Yang, Yue Xue, Yi Huang, Yingxi Mo, Yurun Huang, Hong Zhang, Xiaofei Zhang, Weixin Zhao, Bin Jia, Ningning Li, Ning Gao, Yue Yang, Dongxi Xiang, Shan Wang, Yi Qin Gao, Jun Liao

Journal: Cell Discovery

PubMed ID: 40324980

Doi: 10.1038/s41421-025-00777-1

Products & Services: Protein and Antibody Isolation

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

Authors: Meng Jiang, Qingqing Li, Jianhui Chen, Ruochong Li, Jun Yao, Yong Hu, Haizheng Zhang, Lixin Cai, Maoguo Luo, Yu Sun, Wenwen Zeng

Journal: Advanced Science

PubMed ID: 40349168

Doi: 10.1002/advs.202417733

Products & Services: Protein and Antibody Isolation

HR eye & MMR eye: one-day assessment of DNA repair-defective tumors eligible for targeted therapy

Authors: Shinta Saito, Shingo Kato, Usaki Arai, Atsuki En, Jun Tsunezumi, Taichi Mizushima, Kensuke Tateishi, Noritaka Adachi

Journal: Nature Communications

PubMed ID: 40355434

Doi: 10.1038/s41467-025-59462-2

Products & Services: Gene Synthesis

A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA

Authors: Jonas Aretz, Gayathri Jeyasankar, Anna Salerno-Kochan, Maren Thomsen, Gabriel Thieulin-Pardo, Tasir Haque, Edith Monteagudo, Dan Felsenfeld, Michael Finley, Thomas F Vogt, Julien Boudet, Brinda C Prasad

Journal: Nature Communications

PubMed ID: 40368883

Doi: 10.1038/s41467-025-59324-x

Products & Services: Gene Synthesis

Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3

Authors: Qishun Zhou, Theo Sagmeister, Saskia Hutten, Benjamin Bourgeois, Tea Pavkov-Keller, Dorothee Dormann, Tobias Madl

Journal: Nature Communications

PubMed ID: 40360518

Doi: 10.1038/s41467-025-59802-2

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