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Chemoenzymatic Synthesis of the Cyclopiane Family of Diterpenoid Natural Products

Authors: Zhengren Xu, Tao Wang, Jiasheng Zou, Kaibiao Wang, Yuanning Liu, Shouqi Zhang, Yao Kong

Journal: Angew Chem Int Ed Engl

PubMed ID: 39601390

Doi: 10.1002/anie.202419092

Products & Services: Gene Synthesis

Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses.

Authors: Tyler M. Renner, Matthew Stuible, Brian Cass, Sylvie Perret, Julie Guimond, Simon Lord-Dufour, Michael J. McCluskie, Yves Durocher & Bassel Akache

Journal: npj Viruses

Doi: 10.1038/s44298-024-00067-9

Products & Services: Gene Synthesis

Supramolecular complexes of GCAP1: implications for inherited retinal dystrophies

Authors: Amedeo Biasi, Valerio Marino, Giuditta Dal Cortivo, Daniele Dell'Orco

Journal: International Journal of Biological Macromolecules

PubMed ID: 39187109

Doi: doi.org/10.1016/j.ijbiomac.2024.135068

Products & Services: Peptide Synthesis PCR Cloning and Subcloning Mutagenesis Services

Expression and functional study of DNA polymerases from Psychrobacillus sp. BL-248-WT-3 and FJAT-21963

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yuanchen Mao , Yun He , Hui Tian

Journal: Front Microbiol

PubMed ID: 39633807

Doi: doi.org/10.3389/fmicb.2024.1501020

Products & Services: Gene Synthesis

Computation-driven redesign of an NRPS-like carboxylic acid reductase improves activity and selectivity

Authors: Kun Shi, Ju-Mou Li, Mu-Qiang Wang, Yi-Ke Zhang, Zhi-Jun Zhang, Qi Chen, Frank Hollmann, Jian-He Xu, Hui-Lei Yu

Journal: SCIENCE ADVANCES

PubMed ID: 39612335

Doi: 10.1126/sciadv.adp6775

Products & Services: Gene Synthesis

An Isopentenol Utilization Pathway-Based “Deuterium-Scanning“Method for Mechanistic Investigations of Terpene Cyclases

Authors: Shouqi Zhang, Kaibiao Wang,Yuanning Liu, Tao Wang, Yao Kong, Pengcheng Zhang, Bo Zhang, Min Yin, Guohui Pan, and Zhengren Xu

Journal: ACS catalysis

Doi: 10.1021/acscatal.4c05811

Products & Services: Gene Synthesis

Bivalent CD47 immunotoxin for targeted therapy of T-cell acute lymphoblastic leukemia

Authors: Jihong Ma , Zhaohui Wang , Danielle Mintzlaff , Huiping Zhang , Rashmi Ramakrishna , Eduardo Davila , Matthew T Witkowski , M Scott Lucia , Marc S Schwartz , Elizabeth A Pomfret , David W Mathes , Zhirui Wang

Journal: Blood

PubMed ID: 39561285

Doi: 10.1182/blood.2024025277

Products & Services: Gene Synthesis

Oncogenic cholesterol rewires lipid metabolism in hepatocellular carcinoma via the CSNK2A1-IGF2R Ser2484 axis

Authors: Ren-Yi Su, Chen-Hao Xu, Hai-Jun Guo, Li-Jun Meng, Jian-Yong Zhuo, Nan Xu, Hui-Gang Li, Chi-Yu He, Xuan-Yu Zhang, Zheng-Xin Lian, Shuai Wang, Chenhao Cao, Ruhong Zhou, Di Lu, Shu-Sen Zheng, Xu-Yong Wei, Xiao Xu

Journal: J Adv Res

PubMed ID: 39547439

Doi: 10.1016/j.jare.2024.11.021

Products & Services: Protein Electrophoresis and Western

Evolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction

Authors: Xin-Xin Zhu, Wen-Qing Zheng, Zi-Wei Xia, Xin-Ru Chen, Tian Jin, Xu-Wei Ding, Fei-Fei Chen, Qi Chen, Jian-He Xu, Xu-Dong Kong, Gao-Wei Zheng

Journal: Nat Commun

PubMed ID: 39609402

Doi: 10.1038/s41467-024-54613-3

Products & Services: Plasmid DNA Preparation

Identification of FBLL1 as a neuron-specific RNA 2'-O-methyltransferase mediating neuronal differentiation

Authors: Deyu Zhang , Bo Li , Henan Xu , Jingying Li , Chao Ma , Wei Ge , Congcong Lu , and Xuetao Cao