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Alpha and gamma mangostins inhibit wild-type B SARS-CoV-2 more effectively than the SARS-CoV-2 variants and the major target is unlikely the 3C-like protease

Authors: Aphinya Suroengrit, Van Cao, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Kowit Hengphasatporn, Ryuhei Harada, Supakarn Chamni, Asada Leelahavanichkul, Yasuteru Shigeta, Thanyada Rungrotmongkol, Supot Hannongbua, Warinthorn Chavasiri, Supaporn Wacharapluesadee, Eakachai Prompetchara, Siwaporn Boonyasuppayakorn

Journal: Heliyon

PubMed ID: 38867992

Doi: 10.1016/j.heliyon.2024.e31987

Products & Services: Serology SARS-Cov-2 detection kits

Discovery of UMI-77 as a novel Ku70/80 inhibitor sensitizing cancer cells to DNA damaging agents in vitro and in vivo

Authors: Xuening Chen, Changkun Chen, Chengmiao Luo, Jianyong Liu, Zhonghui Lin

Journal: Eur J Pharmacol

PubMed ID: 38754534

Doi: 10.1016/j.ejphar.2024.176647

Products & Services: Molecular Biology Reagents

Discrimination of Aspartic and Isoaspartic Acid Residues in Peptides by Tandem Mass Spectrometry with Hydrogen Attachment Dissociation

Authors: Daiki Asakawa, Shinich Iwamoto, Koichi Tanaka

Journal: Anal Chem

PubMed ID: 38741470

Doi: 10.1021/acs.analchem.4c00561

Products & Services: Catalog Peptides

Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing

Authors: Qiubing Chen, Xuebin Wang, Yizhou Zhang, Ming Tian, Junyi Duan, Ying Zhang, Hao Yin

Journal: NSR

Doi: 10.1093/nsr/nwae135

Products & Services: Gene Synthesis

Saccharomyces cerevisiae oral immunization in mice using multi-antigen of the African swine fever virus elicits a robust immune response

Authors: Shuo Gao, Wenfeng Zuo, Chao Kang, Zhong Zou, Kaiqi Zhang, Jun Qiu, Xiaomin Shang, Jingjing Li, Yuanfeng Zhang, Qi Zuo, Ya Zhao, Meilin Jin

Journal: Front Immunol

PubMed ID: 38742108

Doi: 10.3389/fimmu.2024.1373656

Products & Services: Gene Synthesis

Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase

Authors: Tao Zhang, Feiyu Zhao, Jinze Li, Xiaodi Sun, Xiyun Zhang, Hejun Wang, Peng Fan, Liangxue Lai, Zhanjun Li, Tingting Sui

Journal: Nucleic Acids Res

PubMed ID: 38366553

Doi: 10.1093/nar/gkae110

Products & Services: Molecular Biology Reagents

One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse

Authors: Marco Malatesta, Emanuele Fornasier, Martino Luigi Di Salvo, Angela Tramonti, Erika Zangelmi, Alessio Peracchi, Andrea Secchi, Eugenia Polverini, Gabriele Giachin, Roberto Battistutta, Roberto Contestabile, Riccardo Percudani

Journal: Nat Commun

PubMed ID: 38615009

Doi: 10.1038/s41467-024-47466-3

Products & Services: Molecular Biology Reagents

pH-dependent regulation of an acidophilic -acetylhomoserine sulfhydrylase from

Authors: Yasuyuki Matoba, Kosuke Oda, Maho Wataeda, Hina Kanemori, Koichi Matsuo

Journal: Appl Environ Microbiol

PubMed ID: 38568076

Doi: 10.1128/aem.00118-24

Products & Services: Mutagenesis Services

Food for Thought: The Effects of Feeding on Neurogenesis in the Ball Python, Python regius

Authors: Hannah Bow, Christina Dang, Katherine Hillsbery, Carly Markowski, Michael Black, Christine Strand