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Predicting the Anti-SARS-CoV-2 Potential of Isoquinoline Alkaloids from Brazilian Siparunaceae Species Using Chemometric Tools

Authors: Brendo Araujo Gomes; Di gina Ara jo Fernandes; Simony Carvalho Mendon a; Mariana Freire Campos; Thamirys Silva da Fonseca; Larissa Esteves Carvalho Constant; Natalia Ferreira de Sousa; Renata Priscila Barros de Menezes; Beatriz Albuquerque Cust dio de Oliveira; Stephany da Silva Costa; Giovanna Barbosa Frensel; Alice Santos Rosa; Thamara Kelcya Fonseca Oliveira; Amanda Resende Tucci; J lia Nilo Henrique Lima; Vivian Neuza Santos Ferreira; Milene Dias Miranda; Diego Allonso; Marcus Tullius Scotti; Suzana Guimar es Leit o; Gilda Guimar es Leit o

Journal: International Journal of Molecular Sciences

PubMed ID: 39859347

Doi: 10.3390/ijms26020633

Products & Services: Peptide Synthesis

Tuning the sensitivity of mechanosensory receptors through histidine scanning

Authors: Yuanhao Wang, Yuhan Wang, Wenjie Yuan, Mingyu Fan, Xiaojing Wang, Anhui Wang, Yanling Bao, Yajing Zhang, Jia Chi Tan, Jianglai Wang, Junshuang Liu, Tianqi Huang, Zixuan Han, Biling Pei, Lijuan Chen, Zhengxu Ren, Xueqing Wang, Lanxin Hu, Siqi Wu, Mengke Pang, Sifan Wang, Zihuan Yang, Jiaze Li, Delian Huang, Shuai Shao, Huairui Yuan, Ling Wu, Yinnian Feng, Penghui Zhou, Guohui Li, Bo Sun, Chenqi Xu, Nicholas R J Gascoigne, Xiang Zhao

Journal: Cell

PubMed ID: 41713420

Doi: 10.1016/j.cell.2025.12.050

Products & Services: Peptide Synthesis

Y-shaped nanoprobe-based DNA microarray for rapid detection of multiplex miRNAs with single-nucleotide specificity

Authors: Yichen Du, Rui Sun, Shuang Hao, Fuwan Yang, Qifei Hu, Ruyan Xue

Journal: Microchemical Journal

Doi: 10.1016/j.microc.2026.117169

Products & Services: Custom DNA/RNA Oligos

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Authors: Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu

Journal: Advanced Science

PubMed ID: 41787915

Doi: 10.1002/advs.202520157

Products & Services: Protein Electrophoresis and Western

A biomimetic nanodisc system selectively activates type I interferons by nonclassical STING pathway for cancer immunotherapy

Authors: Qianwen Mu, Haolan Deng, Shuo Li, Xiaoyu An, Xuan Liu, Yue Xi, Hao Liang, Di Sun, Xiaojun Wang, Xue Liu, Gang Liu, Chao Liu

Journal: Nature Communications

PubMed ID: 41917023

Doi: 10.1038/s41467-026-71363-6

Products & Services: Peptide Synthesis Protein Electrophoresis and Western

High-Entropy Alloy Synergized with Gene Editing for Cocktail-Sensitized Radioimmunotherapy of Lung Metastases

Authors: Qianglan Lu, Chengwei Ye, Ruiyue Chen, Zhanqi Xing, Zhiyong Liu, Fei Zeng, Jinglang Gong, Yanfeng Gao, Xiaolian Sun, Shaochun Tang, Yujun Song

Journal: ADVANCED MATERIALS

PubMed ID: 41914367

Doi: 10.1002/adma.202522618

Products & Services: Synthetic Guide RNA

Structural insights into lipid membrane binding by human ferlins

Authors: Constantin Cretu; Aleksandar Chernev; Csaba Zolt n Kib di Szab ; Vladimir Pena; Henning Urlaub; Tobias Moser; Julia Preobraschenski

Journal: The EMBO Journal

PubMed ID: 40437073

Doi: 10.1038/s44318-025-00463-8

A Oligomer Dissociation Is Catalyzed by Fibril Surfaces

Authors: Alexander J. Dear; Dev Thacker; Stefan Wennmalm; Lei Ortigosa-Pascual; Ewa A. Andrzejewska; Georg Meisl; Sara Linse; Tuomas P. J. Knowles

Journal: ACS Chemical Neuroscience

PubMed ID: 38785363

Doi: 10.1021/acschemneuro.4c00127

A Oligomer Dissociation Is Catalyzed by Fibril Surfaces

Authors: Alexander J. Dear; Dev Thacker; Stefan Wennmalm; Lei Ortigosa-Pascual; Ewa A. Andrzejewska; Georg Meisl; Sara Linse; Tuomas P. J. Knowles

Journal: ACS Chemical Neuroscience

PubMed ID: 38785363

Doi: 10.1021/acschemneuro.4c00127

Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis

Authors: Andrew I Wong; Tiago Beites; Kyle A Planck; Rachael A Fieweger; Kathryn A Eckartt; Shuqi Li; Nicholas C Poulton; Brian C VanderVen; Kyu Y Rhee; Dirk Schnappinger; Sabine Ehrt; Jeremy Rock; Bavesh D Kana

Journal: Elife

PubMed ID: 36810158

Doi: 10.7554/eLife.81177