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页码: 103/5358 每页显示数量

Machine learning-assisted substrate binding pocket engineering based on structural information

Authors: Xinglong Wang; Kangjie Xu; Xuan Zeng; Kai Linghu; Beichen Zhao; Shangyang Yu; Kun Wang; Shuyao Yu; Xinyi Zhao; Weizhu Zeng; Kai Wang; Jingwen Zhou

Journal: BRIEFINGS IN BIOINFORMATICS

PubMed ID: 39101501

Doi: 10.1093/bib/bbae381

A Chemically Induced CRISPR/dCas13 FCPF Platform for Precise and Programmable RNA Regulation

Authors: Sebastian Hasselbeck; Jianhui Wang; Zhaodai Bai; Tobias H fner; Gerhard Hummer; Phillip Grote; Xinlai Cheng

Journal: Journal of Medicinal Chemistry

PubMed ID: 41122778

Doi: 10.1021/acs.jmedchem.5c01609

A Chemically Induced CRISPR/dCas13 FCPF Platform for Precise and Programmable RNA Regulation

Authors: Sebastian Hasselbeck; Jianhui Wang; Zhaodai Bai; Tobias H fner; Gerhard Hummer; Phillip Grote; Xinlai Cheng

Journal: Journal of Medicinal Chemistry

PubMed ID: 41122778

Doi: 10.1021/acs.jmedchem.5c01609

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

Authors: Stephen A. Rettie; David Juergens; Victor Adebomi; Yensi Flores Bueso; Qinqin Zhao; Alexandria N. Leveille; Andi Liu; Asim K. Bera; Joana A. Wilms; Alina ffing; Alex Kang; Evans Brackenbrough; Mila Lamb; Stacey R. Gerben; Analisa Murray; Paul M. Levine; Maika Schneider; Vibha Vasireddy; Sergey Ovchinnikov; Oliver H. Weiergr ber; Dieter Willbold; Joshua A. Kritzer; Joseph D. Mougous; David Baker; Frank DiMaio; Gaurav Bhardwaj

Journal: Nature Chemical Biology

PubMed ID: 40542165

Doi: 10.1038/s41589-025-01929-w

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity

Authors: Yue Liu; Chenxi Li; Zirui Wu; Yu Zhao; Tieyan Yin; Xiaopan Liu; Jiaru Hui; Qingyu Wang; Yi Pan; Yaming Shan; Xinglong Qu

Journal: Frontiers in cellular and infection microbiology

PubMed ID: 40270771

Doi: 10.3389/fcimb.2025.1560330

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Constitutive down-regulation of liguleless alleles in sorghum drives increased productivity and water use efficiency

Authors: Nikhil Jaikumar, Truyen Quach, Zhengxiang Ge, Natalya Nersesian, Shirley J Sato, Scott M McCoy, Ming Guo, Andrew D B Leakey, Stephen P Long, Tom Elmo Clemente

Journal: Plant Biotechnology Journal.

PubMed ID: 40452217

Doi: 10.1111/pbi.70150

Products & Services: Gene Synthesis

Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification

Authors: Chung-Yao Hsu, Po-Cheng Tsai, Jung-Chen Lin, Chen-Hsueh Pai, Yun-Jui Teng, Bing-Yu Yao, Cheng-Yin Fei, Gwo Harn Max Shiau, Leon Cw Lin, Sean Lo, Hung-Chih Yang, Che-Ming Jack Hu

Journal: Nature Communications

PubMed ID: 40456725

Doi: 10.1038/s41467-025-60321-3

Products & Services: Endotoxin Detection & Removal System