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Single-cell profiling and genetic regulation of alternative polyadenylation in the human brain

Authors: Jiuhong Nan, Carles A Boix, Shaohui Shi, Xiaoxi Fan, Jiacheng Ni, Kai Wang, Xiaoyu Shuai, Ke Ding, Puqi Wu, Yao An, Na Sun, Lei Hou, Kexuan Chen, Xianpei Huang, Chengyu Li, Leyla Akay, Kate Louderback, Hiba Nawaid, Yongjin P Park, Xudong Fu, Chong Liu, Xiaoyu Li, Yafei Yin, Wei Mo, Zhanghua Yang, Weirui Ma, Xinyang Hu, David A Bennett, Manolis Kellis, Li-Huei Tsai, Shamil Sunyaev, Jingyun Li, Xushen Xiong

Journal: Nature Genetics

PubMed ID: 42816601

Doi: 10.1038/s41588-026-02758-w

Products & Services: Protein Electrophoresis and Western

A biomimetic nanodisc system selectively activates type I interferons by nonclassical STING pathway for cancer immunotherapy

Authors: Qianwen Mu, Haolan Deng, Shuo Li, Xiaoyu An, Xuan Liu, Yue Xi, Hao Liang, Di Sun, Xiaojun Wang, Xue Liu, Gang Liu, Chao Liu

Journal: Nature Communications

PubMed ID: 41917023

Doi: 10.1038/s41467-026-71363-6

Products & Services: Peptide Synthesis Protein Electrophoresis and Western

Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations

Authors: Shiming Gan, Yangyang Li, Lin Yin, Xiaotong Yang, Chen Lou, Sisi Li, Mingde Lin, Xin Li, Wenchao Xu, Jiaming Zhou, Peiran Hu, Zhendong Yao, Yuan Yuan, Jianzhong Sheng, Chen Zhang, Wei Yang, Youjiang Li, Hefeng Huang

Journal: EMBO Molecular Medicine

PubMed ID: 41618099

Doi: 10.1038/s44321-026-00374-z

Products & Services: Protein Electrophoresis and Western

Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection

Authors: Rui Chao, Yexin Wang, Zhan Liu, Tianhao Wan, Yi Mao, Xinru Xie, Lei Sun, Weifeng Xu, Xuzhuo Chen, Shanyong Zhang

Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PubMed ID: PMC12488209

Doi: 10.3892/ijmm.2025.5647

Products & Services: Protein and Antibody Isolation

The EP300-Targeting Drug CCS1477 Inhibits the Growth and Development of Diffuse Large B-Cell Lymphoma by Promoting Apoptosis and Mitophagy to Reduce Drug Resistance

Authors: Rujia Si, Yihan Zhang, Bowen Hu, Yuxin Du, Dan Zou, Shaodi Wen, Xiaoyue Du, Xin Chen, Chen Peng, Shulei Fu, Shiying Zhu, Fan Du, Xiaofeng Sha, Ning Ding, Cong Xu, Bo Shen

Journal: Anti-Cancer Agents in Medicinal Chemistry

Doi: 10.2174/0118715206430859250915050817

Products & Services: Protein Electrophoresis and Western

Rim4-seeded stress granules connect temperature sensing to meiotic regulation

Authors: Rudian Zhang, Shunjin Li, Wenzhi Feng, Suhong Qian, Akshay John Chellappa, Fei Wang

Journal: Nature Communications

PubMed ID: 40593583

Doi: 10.1038/s41467-025-60645-0

Products & Services: Protein Electrophoresis and Western

Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma

Authors: Juanfen Mo, YuXuan Zhang, Chenxi Cao, WeiLi Zheng, Li Zheng, Xiaoguang Wang, Shiyue Wang, Jiayuan Wu, Yi Bao

Journal: Cell Communication and Signaling