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Heterologous Synthesis and Secretion of Ricinoleic Acid in Starmerella bombicola with Sophorolipid as an Intermediate

Authors: Mohor Chatterjee , Jay B Patel , Spencer T Stober, Xiaozhou Zhang

Journal: ACS Synth Biol

PubMed ID: 35157794

Doi: 10.1021/acssynbio.1c00457

Products & Services: Gene Synthesis

Discovery of potent and versatile CRISPR-Cas9 inhibitors engineered for chemically controllable genome editing

Authors: Guoxu Song , Fei Zhang , Chunhong Tian , Xing Gao, Xiaoxiao Zhu, Dongdong Fan, Yong Tian

Journal: Nucleic Acids Res

PubMed ID: 35188577

Doi: doi.org/10.1093/nar/gkac099

Products & Services: Gene Synthesis

MPLA-Adjuvanted Liposomes Encapsulating S-Trimer or RBD or S1, but Not S-ECD, Elicit Robust Neutralization Against SARS-CoV-2 and Variants of Concern

Authors: Jian Wang, Xu-Guang Yin, Yu Wen, Jie Lu, Ru-Yan Zhang, Shi-Hao Zhou, Chun-Miao Liao, Hua-Wei Wei, Jun Guo

Journal: J Med Chem

PubMed ID: 35108485

Doi: 10.1021/acs.jmedchem.1c02025

Products & Services: Proteins, Expression, Isolation and Analysis

Jasmonic acid biosynthetic genes TgLOX4 and TgLOX5 are involved in daughter bulb development in tulip (Tulipa gesneriana)

Authors: Qi Sun, Bei Zhang, Chaolong Yang, Weiliang Wang, Lin Xiang, Yanping Wang, Zhulong Chan

Journal: Hortic Res

PubMed ID: 35147193

Doi: 10.1093/hr/uhac006

Products & Services: Molecular Biology Tools

Role of IL-17 in Morphogenesis and Dissemination of during Murine Infection

Authors: Nuria Trevijano-Contador, Elena Roselletti, Rocío García-Rodas, Anna Vecchiarelli, Óscar Zaragoza

Journal: Microorganisms

PubMed ID: 35208830

Doi: 10.3390/microorganisms10020373

Products & Services: Recombinant Proteins

CRAF dimerization with ARAF regulates KRAS-driven tumor growth

Authors: Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, Frances Shanahan, Benjamin Haley, Lilian Phu, Erik Verschueren, Trent B Hinkle, David Kan, Ehud Segal, Jason E Long, Tony Lima, Nicholas P D Liau, Jawahar Sudhamsu, Jason Li, Christiaan Klijn, Robert Piskol, Melissa R Junttila, Andrey S Shaw, Mark Merchant, Matthew T Chang, Donald S Kirkpatrick, Shiva Malek

Journal: Cell Rep

PubMed ID: 35139374

Doi: 10.1016/j.celrep.2022.110351

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Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis

Authors: Dogan Can Kirman, Bhuvanasundar Renganathan, Wai Kit Chui, Ming Wei Chen, Neslihan Arife Kaya, Ruowen Ge

Journal: Cell Death Dis

PubMed ID: 35197459

Doi: 10.1038/s41419-022-04618-x

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Recombinant Mosquito Densovirus with Toxins Significantly Improves Pathogenicity against

Authors: Khadija Batool, Intikhab Alam, Peiwen Liu, Zeng Shu, Siyu Zhao, Wenqiang Yang, Xiao Jie, Jinbao Gu, Xiao-Guang Chen

Journal: Toxins (Basel)

PubMed ID: 35202174

Doi: 10.3390/toxins14020147

Products & Services: Gene Synthesis

Cytoplasmic switch of ARS2 isoforms promotes nonsense-mediated mRNA decay and arsenic sensitivity

Authors: Monica Mesa-Perez, Phineas T Hamilton, Alex Miranda, Nicholas Brodie, Connor O'Sullivan, Jennifer Christie, Bridget C Ryan, Robert L Chow, David Goodlett, Christopher J Nelson, Perry L Howard

Journal: Nucleic Acids Res

PubMed ID: 35104878

Doi: 10.1093/nar/gkac033

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Multiple Neuraminidase Containing Influenza Virus-like Particle Vaccines Protect Mice from Avian and Human Influenza Virus Infection

Authors: Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan

Journal: Viruses

PubMed ID: 35216022

Doi: 10.3390/v14020429

Products & Services: Gene Synthesis

Introducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3

Authors: Zhonggang Hou , Chunyi Hu , Ailong Ke , Yan Zhang

Journal: Curr Protoc

PubMed ID: 35129865

Doi: 10.1002/cpz1.361

Products & Services: Gene Synthesis

A Necroptosis-Related Prognostic Model of Uveal Melanoma Was Constructed by Single-Cell Sequencing Analysis and Weighted Co-Expression Network Analysis Based on Public Databases

Authors: Jiaheng Xie, Liang Chen, Qikai Tang, Wei Wei, Yuan Cao, Chuyan Wu, Jing Hang, Kai Zhang, Jingping Shi, Ming Wang

Journal: Front Immunol

PubMed ID: 35242144

Doi: 10.3389/fimmu.2022.847624

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Safety and immunogenicity of a live recombinant Newcastle disease virus-based COVID-19 vaccine (Patria) administered via the intramuscular or intranasal route: Interim results of a non-randomized open label phase I trial in Mexico

Authors: Samuel Ponce-de-León, Martha Torres, Luis Enrique Soto-Ramírez, Juan José Calva, Patricio Santillán-Doherty, Dora Eugenia Carranza-Salazar, Juan Manuel Carreño, Claudia Carranza, Esmeralda Juárez, Laura E Carreto-Binaghi, Luis Ramírez-Martínez, Georgina Paz-De la Rosa, Rosalía Vigueras-Moreno, Alejandro Ortiz-Stern, Yolanda López-Vidal, Alejandro E Macías, Jesús Torres-Flores, Oscar Rojas-Martínez, Alejandro Suárez-Martínez, Gustavo Peralta-Sánchez, Hisaaki Kawabata, Irene González-Domínguez, José Luis Martínez-Guevara, Weina Sun, David Sarfati-Mizrahi, Ernesto Soto-Priante, Héctor Elías Chagoya-Cortés, Constantino López-Macías, Felipa Castro-Peralta, Peter Palese, Adolfo García-Sastre, Florian Krammer, Bernardo Lozano-Dubernard

Journal: medrxiv

PubMed ID: 35169806

Doi: 10.1101/2022.02.08.22270676

Products & Services: Recombinant Proteins

A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

Authors: Adam L Valkovic, Martina Kocan, Brad Hoare, Sarah Marshall, Daniel J Scott, Ross A D Bathgate

Journal: Int J Mol Sci

PubMed ID: 35163827

Doi: 10.3390/ijms23031908

Products & Services: cGMP Peptide Synthesis

Colicin E1 opens its hinge to plug TolC

Authors: S Jimmy Budiardjo, Jacqueline J Stevens, Anna L Calkins, Ayotunde P Ikujuni, Virangika K Wimalasena, Emre Firlar, David A Case, Julie S Biteen, Jason T Kaelber, Joanna S G Slusky

Journal: Elife

PubMed ID: 35199644

Doi: 10.7554/eLife.73297

Products & Services: Proteins, Expression, Isolation and Analysis

Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Authors: Zhi Yang, Kim-Marie A Dam, Michael D Bridges, Magnus A G Hoffmann, Andrew T DeLaitsch, Harry B Gristick, Amelia Escolano, Rajeev Gautam, Malcolm A Martin, Michel C Nussenzweig, Wayne L Hubbell, Pamela J Bjorkman

Journal: Nat Commun

PubMed ID: 35136084

Doi: 10.1038/s41467-022-28424-3

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CRISPR-dCas9 based DNA detection scheme for diagnostics in resource-limited settings

Authors: Michel Bengtson, Mitasha Bharadwaj, Oskar Franch, Jaco van der Torre, Veronique Meerdink, Henk Schallig, Cees Dekker

Journal: Nanoscale

PubMed ID: 35044397

Doi: 10.1039/d1nr06557b

Products & Services: Plasmid DNA Preparation

An engineered bispecific human monoclonal antibody against SARS-CoV-2

Authors: Zhaohui Li, Shihua Li, Gen Zhang, Weiyu Peng, Zhen Chang, Xue Zhang, Zheng Fan, Yan Chai, Feiran Wang, Xin Zhao, Dedong Li, Rong Zhang, Zhanlong He, Weiwei Zou, Ke Xu, Wenwen Lei, Peipei Liu, Junfeng Hao, Jingjing Zhang, Litao Sun, Guizhen Wu, Shuguang Tan, George Fu Gao, Feng Gao, Yan Wu

Journal: Nat Immunol

PubMed ID: 35228696

Doi: 10.1038/s41590-022-01138-w

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Placental methylome reveals a 22q1333 brain regulatory gene locus associated with autism

Authors: Yihui Zhu, J Antonio Gomez, Benjamin I Laufer, Charles E Mordaunt, Julia S Mouat, Daniela C Soto, Megan Y Dennis, Kelly S Benke, Kelly M Bakulski, John Dou, Ria Marathe, Julia M Jianu, Logan A Williams, Orangel J Gutierrez Fugón, Cheryl K Walker, Sally Ozonoff, Jason Daniels, Luke P Grosvenor, Heather E Volk, Jason I Feinberg, M Daniele Fallin, Irva Hertz-Picciotto, Rebecca J Schmidt, Dag H Yasui, Janine M LaSalle

Journal: Genome Biol

PubMed ID: 35168652

Doi: 10.1186/s13059-022-02613-1

Products & Services: Polyclonal Antibody Services

Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy

Authors: Hung X Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M Perelli, Sophia DeLuca, Rachel Yang, Michael Tian, Andrew P Landstrom, Craig Henriquez, Nenad Bursac

Journal: Nat Commun

PubMed ID: 35110560

Doi: 10.1038/s41467-022-28251-6

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Engineered EryF hydroxylase improving heterologous polyketide erythronolide B production in Escherichia coli

Authors: Zhifeng Liu, Jianlin Xu, Haili Liu, Yong Wang

Journal: Microb Biotechnol

PubMed ID: 35174640

Doi: 10.1111/1751-7915.14000

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Antibody responses to 2 doses of mRNA Covid vaccine in pediatric renal patients

Authors: Alison Lap-Tak Ma, Daniel Leung, Eugene Yu-Hin Chan, Stella Chim, Samuel Cheng, Fanny Tsz-Wai Ho, Wai-Ming Lai, Pak-Chiu Tong, Matthew Hon-Lam Lee, Wilfred Hing-Sang Wong, Sau Man Chan, Jaime Rosa Duque, Joseph Sriyal Malik Peiris, Yu-Lung Lau

Journal: Kidney Int

PubMed ID: 35231464

Doi: 10.1016/j.kint.2022.01.035

Products & Services: Proteins, Expression, Isolation and Analysis

Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus

Authors: Sau Yee Tsoi, Merve Öncül, Ella Svahn, Mark Robertson, Zuzanna Bogdanowicz, Christina McClure, Gülşen Sürmeli

Journal: Elife

PubMed ID: 35188100

Doi: 10.7554/eLife.73162

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Performance evaluation of novel fluorescent-based lateral flow immunoassay (LFIA) for rapid detection and quantification of total anti-SARS-CoV-2 S-RBD binding antibodies in infected individuals

Authors: Farah M Shurrab, Nadin Younes, Duaa W Al-Sadeq, Na Liu, Hamda Qotba, Laith J Abu-Raddad, Gheyath K Nasrallah

Journal: Int J Infect Dis

PubMed ID: 35231609

Doi: 10.1016/j.ijid.2022.02.052

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Elucidating the acid-base mechanisms underlying otolith overgrowth in fish exposed to ocean acidification

Authors: Garfield T Kwan, Martin Tresguerres

Journal: Sci Total Environ

PubMed ID: 35143791

Doi: 10.1016/j.scitotenv.2022.153690

Products & Services: Polyclonal Antibody Services

Functional antibody-dependent cell mediated cytotoxicity (ADCC) responses to vaccine and circulating influenza strains following vaccination

Authors: Xuemin Chen, He-Ying Sun, Chun Yi Lee, Christina A Rostad, Jessica Trost, Rodrigo B Abreu, Michael A Carlock, Jason R Wilson, Shane Gansebom, Ted M Ross, David A Steinhauer, Evan J Anderson, Larry J Anderson

Journal: Virology

PubMed ID: 35255298

Doi: 10.1016/j.virol.2022.02.004

Products & Services: Plasmid DNA Preparation

High level SARS-CoV-2 nucleocapsid refolding using mild condition for inclusion bodies solubilization: Application of high pressure at pH 90

Authors: Rosa Maria Chura-Chambi, Alvaro Rossan de Brandão Prieto-da-Silva, Matheus Martins Di Lela, João Ezequiel Oliveira, Patricia Estima Antonia Abreu, Luciana Regina Meireles, Heitor Franco de Andrade Junior, Ligia Morganti

Journal: PLoS ONE

PubMed ID: 35113919

Doi: 10.1371/journal.pone.0262591

Products & Services: Proteins, Expression, Isolation and Analysis

Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection

Authors: John P Evans, Cong Zeng, Claire Carlin, Gerard Lozanski, Linda J Saif, Eugene M Oltz, Richard J Gumina, Shan-Lu Liu

Journal: Sci Transl Med

PubMed ID: 35166573

Doi: 10.1126/scitranslmed.abn8057

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Dissolving Microneedle Delivery of a Prophylactic HPV Vaccine

Authors: Sayoni Ray, David M Wirth, Oscar A Ortega-Rivera, Nicole F Steinmetz, Jonathan K Pokorski

Journal: Biomacromolecules

PubMed ID: 35139303

Doi: 10.1021/acs.biomac.1c01345

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Discrepant serological findings in SARS-CoV-2 PCR negative, hospitalised patients with fever and acute respiratory symptoms during the pandemic

Authors: Gail Brenda Cross, Claire M Naftalin, Jinghao Nicholas Ngiam, Natasha Bagdasarian, Chek Meng Poh, Yun Shan Goh, Wan Ni Chia, Siti Naqiah Amrun, Sai Meng Tham, Hazel Teng, Rawan Alagha, Shoban Krishna Kumar, Shaun Shi Yan Tan, Lin Fa Wang, Paul Anantharajah Tambyah, Laurent Renia, Dale Fisher, Lisa F P Ng

Journal: J Med Virol

PubMed ID: 35171507

Doi: 10.1002/jmv.27656

Bioinformatic characterization of a triacylglycerol lipase produced by isolated from the decaying seed of

Authors: Benjamin O Ezema, Kingsley O Omeje, Roslyn M Bill, Alan D Goddard, Sabinus Oscar O Eze, Alfred Fernandez-Castane

Journal: J Biomol Struct Dyn

PubMed ID: 35147487

Doi: 10.1080/07391102.2022.2035821

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Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease

Authors: Gapisha Karunakaran, Yidai Yang, Véronique Tremblay, Zhibin Ning, Jade Martin, Amine Belaouad, Daniel Figeys, Joseph S Brunzelle, Patrick M Giguere, Alain Stintzi, Jean-François Couture

Journal: FEBS Lett

PubMed ID: 35122247

Doi: 10.1002/1873-3468.14295

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Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease

Authors: Gapisha Karunakaran, Yidai Yang, Véronique Tremblay, Zhibin Ning, Jade Martin, Amine Belaouad, Daniel Figeys, Joseph S Brunzelle, Patrick M Giguere, Alain Stintzi, Jean-François Couture

Journal: FEBS Lett

PubMed ID: 35122247

Doi: 10.1002/1873-3468.14295

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APLNR Regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells

Authors: Yingying Liu, Xiaochuan Ma, Hui Yang, Xun Li, Yingli Ma, Brandon Ason, Suling Liu, Liaoyuan A Hu

Journal: Biochem J

PubMed ID: 35084016

Doi: 10.1042/BCJ20210813

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Tetrahymena thermophila granule lattice protein 3 improves solubility of sexual stage malaria antigens expressed in Escherichia coli

Authors: Cengiz Akkale, Donna Marie Cassidy-Hanley, Theodore G Clark

Journal: Protein Expr Purif

PubMed ID: 35134517

Doi: 10.1016/j.pep.2022.106060

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Crp/fnr family protein binds to promoters of atxA and sodmn genes that regulate the expression of exotoxins in Bacillus anthracis

Authors: Divya Goel, Sudhir Kumar, Gopal Krishna Joshi, Prashant Rai, Rakesh Bhatnagar

Journal: Protein Expr Purif

PubMed ID: 35114377

Doi: 10.1016/j.pep.2022.106059

Products & Services: Recombinant Antibody Expression

Discrepant serological findings in SARS-CoV-2 PCR negative, hospitalised patients with fever and acute respiratory symptoms during the pandemic

Journal: J Med Virol

PubMed ID: 35171507

Doi: 10.1002/jmv.27656

Immunoaffinity monoliths for multiplexed extraction of preterm birth biomarkers from human blood serum in 3D printed microfluidic devices

Authors: Haifa M Almughamsi, Makella K Howell, Samuel R Parry, Joule E Esene, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley

Journal: Analyst

PubMed ID: 35103723

Doi: 10.1039/d1an01365c

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Transformation of by for the Expression of the Hemagglutinin of Avian Influenza Virus H5

Authors: Inkar Castellanos-Huerta, Gabriela Gómez-Verduzco, Guillermo Tellez-Isaias, Guadalupe Ayora-Talavera, Bernardo Bañuelos-Hernández, Víctor Manuel Petrone-García, Gilberto Velázquez-Juárez, Isidro Fernández-Siurob

Journal: Microorganisms

PubMed ID: 35208815

Doi: 10.3390/microorganisms10020361

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Comparison of Neutralizing Antibody Responses at 6 Months Post Vaccination with BNT162b2 and AZD1222

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Zoi Evangelakou, Maria Gavriatopoulou, Maria S Manola, Panagiotis Malandrakis, Despoina D Gianniou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Biomedicines

PubMed ID: 35203547

Doi: 10.3390/biomedicines10020338

The Anticancer Effect of a Conjugated Antimicrobial Peptide Against Colorectal Cancer (CRC) Cells

Authors: Raed Obaid Saleh, Ihsan Naji Atiyah Essia, Saade Abdalkareem Jasim

Journal: J Gastrointest Cancer

PubMed ID: 35217999

Doi: 10.1007/s12029-021-00799-4

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Calcium and integrin-binding protein 1-like interacting with an integrin α-cytoplasmic domain facilitates cellular immunity in Helicoverpa armigera

Authors: Ming-Ming Zhang, Ling-Ling Luo, Yu Liu, Gui-Jie Wang, Huan-Huan Zheng, Xu-Sheng Liu, Jia-Lin Wang

Journal: Dev Comp Immunol