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Preparative capillary electrophoresis (CE) fractionation of protein digests improves protein and peptide identification in bottom-up proteomics

Authors: Simon D Weaver, Naviya Schuster-Little, Rebecca J Whelan

Journal: Anal Methods

PubMed ID: 35175250

Doi: 10.1039/d1ay02145a

Products & Services: Catalog Peptides

Genome-wide identification and characterization of AINTEGUMENTA-LIKE (AIL) family genes in apple (Malus domestica Borkh)

Authors: Xiaolei Han, Kai Liu, Gaopeng Yuan, Shanshan He, Peihua Cong, Caixia Zhang

Journal: Genomics

PubMed ID: 35151838

Doi: 10.1016/j.ygeno.2022.110313

Products & Services: Protein Tools

Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1

Authors: Wallace H Liu, Robert E Miner, Brittany N Albaugh, Gene E Ananiev, Scott A Wildman, John M Denu

Journal: Biochemistry

PubMed ID: 35143176

Doi: 10.1021/acs.biochem.1c00698

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NR3C2 suppresses the proliferation, migration, invasion and angiogenesis of colon cancer cells by inhibiting the AKT/ERK signaling pathway

Authors: Jia Li, Zhao Xu

Journal: Mol Med Rep

PubMed ID: 35191517

Doi: 10.3892/mmr.2022.12649

Products & Services: Custom DNA/RNA Oligos

Ecology and Diversity of Culturable Fungal Species Associated with Soybean Seedling Diseases in the Midwestern United States

Authors: Mirian F Pimentel, Ali Y Srour, Amanda J Warner, Jason P Bond, Carl A Bradley, John Rupe, Martin I Chilvers, J Alejandro Rojas, Janette L Jacobs, Christopher R Little, Alison E Robertson, Loren J Giesler, Dean Malvick, Kiersten Wise, Albert Tenuta, Ahmad M Fakhoury

Journal: J Appl Microbiol

PubMed ID: 35226387

Doi: 10.1111/jam.15507

Products & Services: PCR and Cloning

High-throughput split-protein profiling by combining transposon mutagenesis and regulated protein-protein interactions with deep sequencing

Authors: Kai Zhou, Thomas Litfin, Md Solayman, Huijun Zhao, Yaoqi Zhou, Jian Zhan

Journal: Int J Biol Macromol

PubMed ID: 35120933

Doi: 10.1016/j.ijbiomac.2022.01.173

Products & Services: Custom DNA/RNA Oligos

An insect antifreeze protein from Anatolica polita enhances the cryoprotection of Xenopus laevis eggs and embryos

Authors: Predrag Jevtić, K Wade Elliott, Shelby E Watkins, Jonathan A Sreter, Katarina Jovic, Ian B Lehner, Paul W Baures, John G Tsavalas, Daniel L Levy, Krisztina Varga

Journal: J Exp Biol

PubMed ID: 35014670

Doi: 10.1242/jeb.243662

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Ultrasensitive Label-Free DNA Detection Based on Solution-Gated Graphene Transistors Functionalized with Carbon Quantum Dots

Authors: Minghua Deng, Jinhua Li, Bichen Xiao, Zhanpeng Ren, Ziqin Li, Haiyang Yu, Jiashen Li, Jianying Wang, Zhaowei Chen, Xianbao Wang

Journal: Anal Chem

PubMed ID: 35147418

Doi: 10.1021/acs.analchem.1c05309

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Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

Authors: Dapeng Li, David R Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L Sutherland, Esther Lee, Robert Parks, Dieter Mielke, Whitney Edwards, Amanda Newman, Kevin W Bock, Mahnaz Minai, Bianca M Nagata, Matthew Gagne, Daniel Douek, C Todd DeMarco, Thomas N Denny, Thomas H Oguin, Alecia Brown, Wes Rountree, Yunfei Wang, Katayoun Mansouri, Robert J Edwards, Guido Ferrari, Gregory D Sempowski, Amanda Eaton, Juanjie Tang, Derek W Cain, Sampa Santra, Norbert Pardi, Drew Weissman, Mark Tomai, Christopher Fox, Ian N Moore, Hanne Andersen, Mark G Lewis, Hana Golding, Surender Khurana, Robert Seder, Ralph S Baric, David C Montefiori, Kevin O Saunders, Barton F Haynes

Journal: biorxiv

PubMed ID: 35118474

Doi: 10.1101/2022.01.26.477915

Products & Services: Plasmid DNA Preparation

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

Journal: biorxiv

PubMed ID: 35118474

Doi: 10.1101/2022.01.26.477915

Products & Services: Plasmid DNA Preparation

E-cigarette and food flavoring diacetyl alters airway cell morphology, inflammatory and antiviral response, and susceptibility to SARS-CoV-2

Authors: Stephanie N Langel, Francine L Kelly, David M Brass, Andrew E Nagler, Dylan Carmack, Joshua J Tu, Tatianna Travieso, Ria Goswami, Sallie R Permar, Maria Blasi, Scott M Palmer

Journal: Cell Death Discov

PubMed ID: 35169120

Doi: 10.1038/s41420-022-00855-3

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Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana

Authors: Xiaodong Su, Duanfang Cao, Xiaowei Pan, Lifang Shi, Zhenfeng Liu, Luca Dall'Osto, Roberto Bassi, Xinzheng Zhang, Mei Li

Journal: Mol Plant

PubMed ID: 35123031

Doi: 10.1016/j.molp.2022.01.020

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Structure−Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels

Authors: Naglaa Salem El-Sayed, Young-Woo Nam, Polina A Egorova, Hai Minh Nguyen, Razan Orfali, Mohammad Asikur Rahman, Grace Yang, Heike Wulff, Ilya Bezprozvanny, Keykavous Parang, Miao Zhang

Journal: J Med Chem

PubMed ID: 34962403

Doi: doi/10.1021/acs.jmedchem.1c01473.

Products & Services: PCR Cloning and Subcloning

A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

Authors: Qian Yuan, Qian Ren, Li Li , Huishi Tan, Meizhi Lu, Yuan Tian, Lu Huang, Boxin Zhao, Haiyan Fu, Fan Fan Hou, Lili Zhou, Youhua Liu

Journal: Nat Commun

PubMed ID: 35064106

Doi: 10.1038/s41467-022-28096-z

Products & Services: Peptide Synthesis

A Novel Peptide Derived from Induces Apoptosis in Colorectal Cancer Cells through Mitochondria and the p38 MAPK Pathway

Authors: Chunlei Li, Sirui Zhang, Jianhua Zhu, Weijuan Huang, Yuanyuan Luo, Hui Shi, Dongbo Yu, Liguo Chen, Liyan Song, Rongmin Yu

Journal: Mar Drugs

PubMed ID: 35200639

Doi: 10.3390/md20020110

Products & Services: GenParts™ DNA Fragments

Channelopathy-causing mutations in the SA/SB and HA/HB helices of K23 and K31 channels alter their apparent Ca sensitivity

Authors: Razan Orfali, Young-Woo Nam, Hai Minh Nguyen, Mohammad Asikur Rahman, Grace Yang, Meng Cui, Heike Wulff, Miao Zhang

Journal: Cell Calcium

PubMed ID: 35030515

Doi: 10.1016/j.ceca.2022.102538

Products & Services: Mutagenesis Services

Synthetic nanobody-functionalized nanoparticles for accelerated development of rapid, accessible detection of viral antigens

Authors: Xiahui Chen, Shoukai Kang, Md Ashif Ikbal, Zhi Zhao, Yuxin Pan, Jiawei Zuo, Liangcai Gu, Chao Wang

Journal: Biosens Bioelectron

PubMed ID: 35051851

Doi: 10.1016/j.bios.2022.113971

Products & Services: Proteins, Expression, Isolation and Analysis

Mapping Critical Residues in ATG11's Coiled-Coil 2 Domain that Block Multiple Interactions and Disrupt Selective Autophagy

Authors: Mitchell D Meyer, Jasmine Winzeler, Sophia M Taylor, Alex Kilgore, Kimberly Edicha, Chase Chitwood, Zachary Spearin, S K Nadia Rahman Silvia, Ronith Chakraborty, Jesse E Smith, Bridget Kennedy, Carson Zois, Hayley Cawthon, Mukiri Gilruth, Steven K Backues

Journal: Front Cell Dev Biol

PubMed ID: 35118068

Doi: 10.3389/fcell.2021.775364

Products & Services: Mutagenesis Services

Cadherin switches during epithelial-mesenchymal transition: CDH4/RCAD downregulation reduces bladder cancer progression

Authors: Cláudia Martins-Lima, Vera Miranda-Gonçalves, João Lobo, Vera Constâncio, Pedro Leite-Silva, Catarina Guimarães-Teixeira, Sara Monteiro-Reis, José Pedro Sequeira, Mariana Cantante, Céline S Gonçalves, Bruno M Costa, Rui Henrique, Carmen Jerónimo

Journal: Cell Oncol (Dordr)

PubMed ID: 35064910

Doi: 10.1007/s13402-021-00657-2

Products & Services: Plasmid DNA Preparation

Novel TRPV1 Modulators with Reduced Pungency Induce Analgesic Effects in Mice

Authors: Anny Treat, Vianie Henri, Junke Liu, Joyce Shen, Mauricio Gil-Silva, Alejandro Morales, Avaneesh Rade, Kevin Joseph Tidgewell, Benedict Kolber, Young Shen

Journal: ACS Omega

PubMed ID: 35097287

Doi: 10.1021/acsomega.1c05727

Products & Services: Plasmid DNA Preparation

Peroxisomal ATP Uptake Is Provided by Two Adenine Nucleotide Transporters and the ABCD Transporters

Authors: Carlo W T van Roermund, Lodewijk IJlst, Nicole Linka, Ronald J A Wanders, Hans R Waterham

Journal: Front Cell Dev Biol

PubMed ID: 35127709

Doi: 10.3389/fcell.2021.788921

Products & Services: ORF cDNA Clones/MolecularCloud

An Enzymatic Biosensor for the Detection of D-2-Hydroxyglutaric Acid in Serum and Urine

Authors: Bo Wu, Zehua Li, Zepeng Kang, Chunling Ma, Haiyan Song, Fuping Lu, Zhiguang Zhu

Journal: Biosensors (Basel)

PubMed ID: 35200327

Doi: 10.3390/bios12020066

Products & Services: Codon Optimization

CD8 T-Cell Epitope Variations Suggest a Potential Antigen HLA-A2 Binding Deficiency for Spike Protein of SARS-CoV-2

Authors: Congling Qiu, Chanchan Xiao, Zhigang Wang, Guodong Zhu, Lipeng Mao, Xiongfei Chen, Lijuan Gao, Jieping Deng, Jun Su, Huanxing Su, Evandro Fei Fang, Zhang-Jin Zhang, Jikai Zhang, Caojun Xie, Jun Yuan, Oscar Junhong Luo, Li An Huang, Pengcheng Wang, Guobing Chen

Journal: Front Immunol

PubMed ID: 35116022

Doi: 10.3389/fimmu.2021.764949

Products & Services: Peptide Synthesis

Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticity

Authors: Jia-Wei Yang, Yu-Rou Lin, Ying-Ling Chu, Johnson H Y Chung, Huai-En Lu, Guan-Yu Chen

Journal: Commun Biol

PubMed ID: 35046486

Doi: 10.1038/s42003-022-03026-3

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Development and Evaluation of a Molecular Hepatitis A Virus Assay for Serum and Stool Specimens

Authors: Robert A Kozak, Candace Rutherford, Melissa Richard-Greenblatt, N Y Elizabeth Chau, Ana Cabrera, Mia Biondi, Jamie Borlang, Jaqueline Day, Carla Osiowy, Sumathi Ramachandran, Nancy Mayer, Laurel Glaser, Marek Smieja

Journal: Viruses

PubMed ID: 35062362

Doi: 10.3390/v14010159

Products & Services: Plasmid DNA Preparation

Differential T cell immune responses to deamidated adeno-associated virus vector

Authors: So Jin Bing, Sune Justesen, Wells W Wu, Abdul Mohin Sajib, Stephanee Warrington, Alan Baer, Stephan Thorgrimsen, Rong-Fong Shen, Ronit Mazor

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35211638

Doi: 10.1016/j.omtm.2022.01.005

Products & Services: Peptide Synthesis

Characterization of a Novel Chimeric p67 Antigen Which Incorporates into Virus-like Particles and Is Highly Immunogenic in Mice

Authors: Leah Whittle, Ros Chapman, Michiel van Diepen, Edward P Rybicki, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 35214669

Doi: 10.3390/vaccines10020210

Products & Services: Codon Optimization

Functionally Antagonistic Transcription Factors IRF1 and IRF2 Regulate the Transcription of the Dopamine Receptor D2 Gene Associated with Aggressive Behavior of Weaned Pigs

Authors: Jing Zhao, Siyuan Gao, Yanli Guo, Qinglei Xu, Mingzheng Liu, Chunlei Zhang, Meng Cheng, Xianle Zhao, Allan P Schinckel, Bo Zhou

Journal: Biology (Basel)

PubMed ID: 35053133

Doi: 10.3390/biology11010135

Products & Services: Proteins, Expression, Isolation and Analysis

Azole-Resistant Alleles of in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors

Authors: Bao Gia Vu, W Scott Moye-Rowley

Journal: Antimicrob Agents Chemother

PubMed ID: 35007132

Doi: 10.1128/AAC.02098-21

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Three-repeat and four-repeat tau isoforms form different oligomers

Authors: Hedieh Shahpasand-Kroner, Jennifer Portillo, Carter Lantz, Paul M Seidler, Natalie Sarafian, Joseph A Loo, Gal Bitan

Journal: Protein Sci

PubMed ID: 34902187

Doi: 10.1002/pro.4257

Products & Services: Proteins, Expression, Isolation and Analysis

FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape

Authors: Lei Wu, Yanquan Xu, Huakan Zhao, Yu Zhou, Yu Chen, Shuai Yang, Juan Lei, Jiangang Zhang, Jingchun Wang, Yongzhong Wu, Yongsheng Li

Journal: Theranostics

PubMed ID: 34976216

Doi: 10.7150/thno.66575

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Modulation of the Conformational Space of SARS-CoV-2 RNA Quadruplex RG-1 by Cellular Components and the Amyloidogenic Peptides α-Synuclein and hIAPP

Authors: Sanjib K Mukherjee, Jim-Marcel Knop, Roland Winter

Journal: Chemistry

PubMed ID: 34882862

Doi: 10.1002/chem.202104182

Products & Services: Mammalian Expression

A model for DHX15 mediated disassembly of A-complex spliceosomes

Authors: Hannah M Maul-Newby, Angela N Amorello, Turvi Sharma, John H Kim, Matthew S Modena, Beth E Prichard, Melissa S Jurica

Journal: RNA

PubMed ID: 35046126

Doi: 10.1261/rna.078977.121

Products & Services: Catalog Antibody

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

Authors: Rhia Kundu, Janakan Sam Narean, Lulu Wang, Joseph Fenn, Timesh Pillay, Nieves Derqui Fernandez, Emily Conibear, Aleksandra Koycheva, Megan Davies, Mica Tolosa-Wright, Seran Hakki, Robert Varro, Eimear McDermott, Sarah Hammett, Jessica Cutajar, Ryan S Thwaites, Eleanor Parker, Carolina Rosadas, Myra McClure, Richard Tedder, Graham P Taylor, Jake Dunning, Ajit Lalvani

Journal: Nat Commun

PubMed ID: 35013199

Doi: 10.1038/s41467-021-27674-x

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Recombinant porphobilinogen deaminase targeted to the liver corrects enzymopenia in a mouse model of acute intermittent porphyria

Authors: Karol M Córdoba, Irantzu Serrano-Mendioroz, Daniel Jericó, María Merino, Lei Jiang, Ana Sampedro, Manuel Alegre, Fernando Corrales, María J Garrido, Paolo G V Martini, José Luis Lanciego, Jesús Prieto, Pedro Berraondo, Antonio Fontanellas

Journal: Sci Transl Med

PubMed ID: 35020410

Doi: 10.1126/scitranslmed.abc0700

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Physicochemical Characterization and In Vitro Digestibility Study of an In Silico Designed Recombinant Protein Enriched with Large Neutral Amino Acids and Lacking Phenylalanine for Phenylketonuria

Authors: Prakruthi Appaiah, L Sunil, Asha Martin, Prasanna Vasu

Journal: Protein J

PubMed ID: 35064867

Doi: 10.1007/s10930-021-10039-0

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Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

Authors: Sheng Jiang, Shuting Wu, Gan Zhao, Yue He, Linlin Bao, Jiangning Liu, Chuan Qin, Jiawang Hou, Yuan Ding, Alex Cheng, Brian Jiang, John Wu, Jian Yan, Laurent Humeau, Ami Patella, David B Weiner, Kate Broderick, Bin Wang

Journal: Hum Vaccin Immunother

PubMed ID: 35061975

Doi: 10.1080/21645515.2021.2016201

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Enzymatic synthesis of cellulose in space: gravity is a crucial factor for building cellulose II gel structure

Authors: Tomohiro Kuga, Naoki Sunagawa, Kiyohiko Igarashi

Journal: Cellulose (Lond)

PubMed ID: 35125685

Doi: 10.1007/s10570-021-04399-0

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Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor

Authors: Longying Jiang, Xueke Liu, Hudie Wei, Shuyan Dai, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Yongheng Chen

Journal: Biochem Biophys Res Commun

PubMed ID: 35091108

Doi: 10.1016/j.bbrc.2022.01.069

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Development of Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen

Authors: Grega Popovic, Nicholas C Kirby, Taylor C Dement, Kristine M Peterson, Caroline E Daub, Heather A Belcher, Martin Guthold, Adam R Offenbacher, Nathan E Hudson

Journal: Int J Mol Sci

PubMed ID: 35162976

Doi: 10.3390/ijms23031054

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Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

Authors: Enquan Xu, Ravindra Boddu, Hisham A Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M Carlisle, Elliot J Lefkowitz, Ashley S Harms, Etty N Benveniste, Talene A Yacoubian, Laura A Volpicelli-Daley, David G Standaert, Andrew B West

Journal: Mol Neurodegener

PubMed ID: 35012605

Doi: 10.1186/s13024-021-00509-5

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Distribution of serotypes and antibiotic resistance of invasive Pseudomonas aeruginosa in a multi-country collection

Authors: Shamima Nasrin, Nicolas Hegerle, Shaichi Sen, Joseph Nkeze, Sunil Sen, Jasnehta Permala-Booth, Myeongjin Choi, James Sinclair, Milagritos D Tapia, J Kristie Johnson, Samba O Sow, Joshua T Thaden, Vance G Fowler, Karen A Krogfelt, Annelie Brauner, Efthymia Protonotariou, Eirini Christaki, Yuichiro Shindo, Andrea L Kwa, Sadia Shakoor, Ashika Singh-Moodley, Olga Perovic, Jan Jacobs, Octavie Lunguya, Raphael Simon, Alan S Cross, Sharon M Tennant

Journal: BMC Microbiol

PubMed ID: 34991476

Doi: 10.1186/s12866-021-02427-4

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Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

Authors: Kylie M Konrath, Kevin Liaw, Yuanhan Wu, Xizhou Zhu, Susanne N Walker, Ziyang Xu, Katherine Schultheis, Neethu Chokkalingam, Himanshi Chawla, Jianqiu Du, Nicholas J Tursi, Alan Moore, Jared Adolf-Bryfogle, Mansi Purwar, Emma L Reuschel, Drew Frase, Matthew Sullivan, Benjamin Fry, Igor Maricic, Viviane M Andrade, Christel Iffland, Max Crispin, Kate E Broderick, Laurent M P F Humeau, Ami Patel, Trevor R F Smith, Jesper Pallesen, David B Weiner, Daniel W Kulp

Journal: Cell Rep

PubMed ID: 35090597

Doi: 10.1016/j.celrep.2022.110318

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Identification of a plant endophytic growth-promoting bacteria capable of inhibiting cadmium uptake in rice

Authors: Wei Tian, Le Li, Xiao Xiao, Huili Wu, Yulong Wang, Zhaoyang Hu, Nahmina Begum, Yiping Zou, Laiqing Lou, Ming Chang, Qingsheng Cai

Journal: J Appl Microbiol

PubMed ID: 34216530

Doi: 10.1111/jam.15201

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CDC42 as an epigenetic regulator of ID4 in triple-negative breast tumors

Authors: Daniela Nasif, Sebastian Real, María Roqué, María T Branham

Journal: Breast Cancer

PubMed ID: 35094293

Doi: 10.1007/s12282-022-01334-4

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Nanobody-based anti-CD22-chimeric antigen receptor T cell immunotherapy exhibits improved remission against B-cell acute lymphoblastic leukemia

Authors: Tingting Zhang, Tian Wang, Fengtao You, Zixuan Li, Dan Chen, Kailu Zhang, Shuaiyu Tian, Binjie Sheng, Hai Wu, Licui Jiang, Renyuxue Ma, Gangli An, Huimin Meng, Lin Yang

Journal: Transpl Immunol

PubMed ID: 35051588

Doi: 10.1016/j.trim.2022.101538

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Induction of humoral and cellular immune responses to COVID-19 mRNA and vector vaccines: A prospective cohort study in Bulgarian healthcare workers

Authors: Maria Nikolova, Yana Todorova, Radoslava Emilova, Iva Trifonova, Teodora Gladnishka, Nina Petrova-Yancheva, Tatyana Chervenyakova, Elena Dragusheva, Georgi Popov, Iva Christova

Journal: J Med Virol

PubMed ID: 34997611

Doi: 10.1002/jmv.27572

MPP1 Determines the Mobility of Flotillins and Controls the Confinement of Raft-Associated Molecules

Authors: Agnieszka Biernatowska, Karolina Wójtowicz, Tomasz Trombik, Aleksander F Sikorski, Aleksander Czogalla

Journal: Cells

PubMed ID: 35159121

Doi: 10.3390/cells11030311

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A Novel Potent Carrier for Unconventional Protein Export in

Authors: Magnus Philipp, Kai P Hussnaetter, Michèle Reindl, Kira Müntjes, Michael Feldbrügge, Kerstin Schipper

Journal: Front Cell Dev Biol

PubMed ID: 35083222

Doi: 10.3389/fcell.2021.816335

Products & Services: Proteins, Expression, Isolation and Analysis

Differential effect of deleting members of African swine fever virus multigene families 360 and 505 from the genotype II Georgia 2007/1 isolate on virus replication, virulence and induction of protection

Authors: Anusyah Rathakrishnan, Samuel Connell, Vlad Petrovan, Katy Moffat, Lynnette C Goatley, Tamara Jabbar, Pedro J Sánchez-Cordón, Ana L Reis, Linda K Dixon

Journal: J Virol

PubMed ID: 35044212

Doi: 10.1128/jvi.01899-21

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