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页码: 97/5153 每页显示数量

Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants

Authors: Martin Grønbæk-Thygesen, Vasileios Voutsinos, Kristoffer E. Johansson, Thea K. Schulze, Matteo Cagiada, Line Pedersen, Lene Clausen, Snehal Nariya, Rachel L. Powell, Amelie Stein, Douglas M. Fowler, Kresten Lindorff-Larsen & Rasmus Hartmann-Petersen

Journal: Nat Commun

PubMed ID: 38740822

Doi: 10.1038/s41467-024-48481-0

Products & Services: Mutagenesis Services

Biosynthetic production of anticoagulant heparin polysaccharides through metabolic and sulfotransferases engineering strategies

Authors: Jian-Qun Deng, Yi Li, Yu-Jia Wang, Ya-Lin Cao, Si-Yu Xin, Xin-Yu Li, Rui-Min Xi, Feng-Shan Wang & Ju-Zheng Sheng

Journal: Nat Commun

PubMed ID: 38704385

Doi: 10.1038/s41467-024-48193-5

Products & Services: Gene Synthesis

A Customized Biohybrid presenting Cascade Responses to Tumor Microenvironment

Authors: Feiyu Li, Peipei Zhu, Bingzhu Zheng, Zijie Lu, Chao Fang, Yike Fu, Xiang Li

Journal: Adv Mater

PubMed ID: 38723206

Doi: 10.1002/adma.202404901

Products & Services: Molecular Biology Reagents

Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN

Authors: Jianhui Wang (王建辉) , Marcel Heinz, Kang Han (韩康), Varun J. Shah, Sebastian Hasselbeck, Martin P. Schwalm, Rajeshwari Rathore, Gerhard Hummer, Jun Zhou (周俊), Ivan Dikic, Xinlai Cheng (承辛来)

Journal: Cell Reports Physical Science

Doi: doi.org/10.1016/j.xcrp.2024.101960

Products & Services: Molecular Biology Reagents

C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD

Authors: Jessica Sultana, Audrey M G Ragagnin, Sonam Parakh, Sayanthooran Saravanabavan, Kai Ying Soo, Marta Vidal, Cyril Jones Jagaraj, Kunjie Ding, Sharlynn Wu, Sina Shadfar, Emily K Don, Anand Deva, Garth Nicholson, Dominic B Rowe, Ian Blair, Shu Yang, Julie D Atkin

Journal: Mol Neurobiol

PubMed ID: 38722513

Doi: 10.1007/s12035-024-04187-4

Products & Services: PCR Cloning and Subcloning

Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington's disease

Authors: Ranen Aviner, Ting-Ting Lee, Vincent B Masto, Kathy H Li, Raul Andino, Judith Frydman

Journal: Nat Cell Biol

PubMed ID: 38741019

Doi: 10.1038/s41556-024-01414-x

Products & Services: ORF cDNA Clones/MolecularCloud

A PACAP-activated network for secretion requires coordination of Ca influx and Ca mobilization

Authors: Xiaohuan Chen, Nicole A Bell, Breanna L Coffman, Agustin A Rabino, Rafael Garcia-Mata, Paul J Kammermeier, David I Yule, Daniel Axelrod, Alan V Smrcka, David R Giovannucci, Arun Anantharam

Journal: Mol Biol Cell

PubMed ID: 38758660

Doi: 10.1091/mbc.E24-02-0083

Products & Services: Molecular Biology Reagents

Disulfidptosis in head and neck squamous carcinoma: Integrative bioinformatic and in-vitro analysis

Authors: Xufeng Huang, Jinyan Yang, Qi Wang, Rao Fu, Xutao Wen, Zhengrui Li, Ling Zhang

Journal: Oral Dis

PubMed ID: 38696646

Doi: 10.1111/odi.14977

Products & Services: Molecular Biology Reagents

Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products

Authors: Xiaomin Huang, Ting Wang, Ludan Wang, Yantao Sun, Ziru Zhang, Yajun Zhang

Journal: BMC Chem

PubMed ID: 38702791

Doi: 10.1186/s13065-024-01198-z

Products & Services: DNA Sequencing

Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools Monitoring Targeted Protein Degradation

Authors: Hanfeng Lin, Kristin Riching, May Poh Lai, Dong Lu, Ran Cheng, Xiaoli Qi, Jin Wang

Journal: biorxiv

PubMed ID: 38798562

Doi: 10.1101/2024.05.14.594249

Products & Services: Molecular Biology Reagents