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The SH protein of mumps virus is a druggable pentameric viroporin

Authors: Kira Devantier, Trine L Toft-Bertelsen, Andreas Prestel, Viktoria M S Kjær, Cagla Sahin, Marco Giulini, Stavroula Louka, Katja Spiess, Asmita Manandhar, Katrine Qvortrup, Trond Ulven, Bo H Bentzen, Alexandre Mjj Bonvin, Nanna MacAulay, Birthe B Kragelund, Mette M Rosenkilde

Journal: SCIENCE ADVANCES

PubMed ID: 40479045

Doi: 10.1126/sciadv.ads3071

Products & Services: Bacterial Expression

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

Authors: Meichen Pan, Chunrong Yang, Zhongliang Fu, Yuchen Yang, Ying Zhuo, Hongwei Hou, Jinghong Li

Journal: Advanced Science

Doi: 10.1002/advs.202501384

Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second-strand nicking

Authors: Akanksha Thawani, Anthony Rodríguez-Vargas, Briana Van Treeck, Nozhat T Hassan, David L Adelson, Eva Nogales, Kathleen Collins

Journal: SCIENCE ADVANCES

PubMed ID: 40540573

Doi: 10.1126/sciadv.adu5533

Structure of bifunctional variediene synthase yields unique insight on biosynthetic diterpene assembly and cyclization

Authors: Eliott S Wenger, David W Christianson

Journal: Nature Communications

PubMed ID: 39677668

Doi: 10.1101/2024.12.03.626647

Products & Services: Custom Vector Construction

RIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1

Authors: Akihito Sakoguchi, Samuel G Chamberlain, Alexander M Mørch, Marcus Widdess, Thomas E Harrison, Michael L Dustin, Hisashi Arase, Matthew K Higgins, Shiroh Iwanaga

Journal: Nature

PubMed ID: 40500441

Doi: 10.1038/s41586-025-09091-y

Products & Services: Gene Synthesis

Identification and characterisation of vaginal bacteria-glycan interactions implicated in reproductive tract health and pregnancy outcomes

Authors: Virginia Tajadura-Ortega, Wengang Chai, Lauren A Roberts, Yibing Zhang, Antonio Di Maio, Alexiane C Decout, Benedita A Pinheiro, Angelina S Palma, Gian De Nicola, Lucia Riaposova, Belen Gimeno-Molina, Yun S Lee, Hongzhi Cao, Vladimir Piskarev, Yukie Akune, Tiago R D Costa, Himani Amin, Lynne Sykes, Phillip R Bennett, Julian R Marchesi, Ten Feizi, Yan Liu, David A MacIntyre

Journal: Nature Communications

PubMed ID: 40467588

Doi: 10.1038/s41467-025-60404-1

Products & Services: PCR Cloning and Subcloning

Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease

Authors: Grace Neilsen, Shuiyun Lan, Ryan L Slack, Zachary C Lorson, Andres Emanuelli Castaner, Rachel Lee, Kristin G Edwards, Huanchun Zhang, Jasper Lee, William A Cantara, Maria E Cilento, Hongwang Zhang, Ramyani De, Franck Amblard, Philip R Tedbury, Karen A Kirby, Raymond F Schinazi, Stefan G Sarafianos

Journal: SCIENCE ADVANCES

PubMed ID: 40479048

Doi: 10.1126/sciadv.adv8875

Products & Services: PCR Cloning and Subcloning

Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation

Authors: Guillem Hernandez, Maria L Martins, Nuno P Fernandes, Tiago Veloso, João Lopes, Tiago Gomes, Tiago N Cordeiro

Journal: Nucleic Acids Research

PubMed ID: 40503686

Doi: 10.1093/nar/gkaf502

Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain

Authors: Guillaume Mas , Sebastian Hiller

Journal: Nature Communications

PubMed ID: 40449998

Doi: 10.1038/s41467-025-60343-x

Products & Services: Gene Synthesis

Designing Sandwich ELISA with Broadly Reactive Anti-Nucleocapsid Monoclonal Antibodies to Detect Bat-Borne Merbecoviruses

Authors: Kong Yen Liew, Yaju Wang, Sneha Sree Mullapudi, Dinah Binte Aziz, Wenjie Fan, Min Luo, Paul Anantharajah Tambyah, Yee-Joo Tan

Journal: Viruses

PubMed ID: 40733504

Doi: 10.3390/v17070886

Products & Services: Gene Synthesis Codon Optimization PCR Cloning and Subcloning