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Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

Authors: Shristi Pawnikar; Brenda S Magenheimer; Keya Joshi; Ericka Nevarez-Munoz; Allan Haldane; Robin L Maser; Yinglong Miao; Qiang Cui; Shristi Pawnikar; Brenda Magenheimer; Keya Joshi; Ericka Nevarez-Munoz; Allan Haldane; Robin Maser; Yinglong Miao

Journal: Elife

PubMed ID: 39373641

Doi: 10.7554/eLife.95992

Products & Services: Peptide Synthesis

Target-based design of praziquantel analogs at cestode TRPM PZQ

Authors: Daniel J. Sprague; Sang-Kyu Park; Marc Kaethner; Claudia M. Rohr; Mina R. Ghobrial; D. Connor Barth; David Maillard; Thomas Spangenberg; Britta Lundstr m-Stadelmann; Jonathan S. Marchant

Journal: ACS Infectious Diseases

PubMed ID: 40754814

Doi: 10.1021/acsinfecdis.5c00449

Target-based design of praziquantel analogs at cestode TRPM PZQ

Authors: Daniel J. Sprague; Sang-Kyu Park; Marc Kaethner; Claudia M. Rohr; Mina R. Ghobrial; D. Connor Barth; David Maillard; Thomas Spangenberg; Britta Lundstr m-Stadelmann; Jonathan S. Marchant

Journal: ACS Infectious Diseases

PubMed ID: 40754814

Doi: 10.1021/acsinfecdis.5c00449

Target-based design of praziquantel analogs at cestode TRPM PZQ

Authors: Daniel J. Sprague; Sang-Kyu Park; Marc Kaethner; Claudia M. Rohr; Mina R. Ghobrial; D. Connor Barth; David Maillard; Thomas Spangenberg; Britta Lundstr m-Stadelmann; Jonathan S. Marchant

Journal: ACS Infectious Diseases

PubMed ID: 40754814

Doi: 10.1021/acsinfecdis.5c00449

Structure of Plasmodium vivax N -myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

Authors: Alex Mendez; Cydni Bolling; Shane Taylor; Stanley Makumire; Bart Staker; Alexandra Reers; Brad Hammerson; Stephen J. Mayclin; Jan Abendroth; Donald D. Lorimer; Thomas E. Edwards; Edward W. Tate; Sandhya Subramanian; Andrew S. Bell; Peter J. Myler; Oluwatoyin A. Asojo; Graham Chakafana

Journal: Acta Crystallographica Section F: Structural Biology Communications

PubMed ID: 39655507

Doi: 10.1107/S2053230X24011348

Molecular Modeling and In Vitro Functional Analysis of the RGS12 PDZ Domain Variant Associated with High-Penetrance Familial Bipolar Disorder

Authors: Percy S Agogo-Mawuli, Joseph Mendez, Emily A Oestreich, Dustin E Bosch, David P Siderovski

Journal: International Journal of Molecular Sciences

PubMed ID: 39518985

Doi: 10.3390/ijms252111431

Products & Services: Peptide Synthesis Bacterial Expression

Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations

Authors: Yoshita Srivastava , Olayinka Akinyemi , Tiana C Rohe , Elizabeth M Pritchett , Cameron D Baker , Akshara Sharma , Jermaine L Jenkins , David H Mathews , Joseph E Wedekind

Journal: Nucleic Acids Research

PubMed ID: 39413212

Doi: 10.1093/nar/gkae886

Products & Services: CRISPR KI Templates PCR Cloning and Subcloning Mutagenesis Services

Disrupting Intracellular Homeostasis by Copper-Based Nanoinducer with Multiple Enzyme-Mimicking Activities to Induce Disulfidptosis-Enhanced Pyroptosis for Tumor Immunotherapy

Authors: Xiao-Kang Jin , Shun-Kang Zhang , Shi-Man Zhang , Jun-Long Liang , Xiao Yan , Yan-Tong Lin , Ran Meng , Zi-Han Xu , Chuan-Jun Liu , Xian-Zheng Zhang

Journal: ADVANCED MATERIALS

PubMed ID: 39468892

Doi: 10.1002/adma.202410957

Products & Services: Recombinant Proteins

The TMEM63B Channel Facilitates Intestinal Motility and Enhances Proliferation of Intestinal Stem Cells

Authors: Jing-Jing Tu , Yan-Yu Zang , Yun Stone Shi ,and Xiao-Yu Teng

Journal: Cells

Doi: doi.org/10.3390/cells13211784

Products & Services: Molecular Biology Reagents

5′-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response

Authors: Hanyong Jin , Ji-Hyun Yeom , Eunkyoung Shin , Yoonjie Ha , Haifeng Liu , Daeyoung Kim , Minju Joo , Yong-Hak Kim , Hak Kyun Kim , Minkyung Ryu, Hong-Man Kim , Jeongkyu Kim , Keun P Kim , Yoonsoo Hahn , Jeehyeon Bae , Kangseok Lee

Journal: Nature Communications

PubMed ID: 39468069

Doi: 10.1038/s41467-024-53624-4

Products & Services: Custom Vector Construction