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A novel alphavirus-based saRNA platform for enhanced vaccination efficacy and organ-specific targeting

Authors: Zhen Sun, Yuxiao Liu, Haoyi Zhang, Ting Ge, Yuting Pan, Yang Liu, Miaomiao Wu, Tao Shan, Guoqiang Zhu, Qi Wu, Kangming Chen

Journal: Vaccine

PubMed ID: 41349243

Doi: 10.1016/j.vaccine.2025.128055

Products & Services: Custom mRNA synthesis

Ultrafast and Green Encapsulation of Enzymes in Biotitania Nanoparticles via Elastin-like Polypeptide-Mediated Biomimetic Mineralization

Authors: Lin, Yuanqing; He, Yichen; He, Ziyun; Zhan, Weichen; Huang, Yidan; Li, Xue; Cai, Jinzhong; Chen, Lanfang; Xiao, Zushun; Liu, Xingxing; Zhang, Guangya

Journal: ACS Sustainable Chemistry & Engineering

Doi: 10.1021/acssuschemeng.5c12382

Products & Services: Protein Electrophoresis and Western

Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates

Authors: Ignacio Relano-Rodriguez, Jianqiu Du, Zi Jie Lin, Margaret Kerwin, Marta Tarquis-Medina, Eduardo Urbano, Jiayan Cui, Meagan Watkins, Christy L Lavine, Peng Zhao, Rumi Habib, Colby Agostino, Sukanya Ghosh, Joyce Park, Caroline Boroughs, Agnes A Walsh, Mariane B Melo, Niharika Shukla, George M Shaw, Beatrice H Hahn, Darrell J Irvine, Lance Wells, David B Weiner, Michael S Seaman, Daniel W Kulp, Ronald S Veazey, Jesper Pallesen, Amelia Escolano

Journal: nature immunology

PubMed ID: 41634485

Doi: 10.1038/s41590-025-02408-z

Expression of IMD-CBM peptide induces the autophagic degradation of CAV1 (caveolin 1) to inhibit LDL transcytosis and retard diabetic atherosclerosis

Authors: Li Wang, Xiong Jia, Xiangli Bai, Ying Zhao, Wenzhuo Cheng, Meng Shu, Yan Shu, Liyin Zhang, Ruonan Wang, Si Jin

Journal: Autophagy

PubMed ID: 41686177

Doi: 10.1080/15548627.2026.2631946

CD3ɛ Nanobody-Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE-Secreting CAR-Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Authors: Shi-Wei Huang, Yu-Chuan Lin, Chih-Ming Pan, Yeh Chen, Ming-You Shie, Cheng-Yu Chen, Kai-Wen Kan, Yi-Wen Chen, Ming-Chao Liu, Chung-Chun Wu, Yu-Ting Chiang, Huai-Ping Ho, Chen-Yu Lin, Pei-Ying Lin, Yu-Han Huang, Steffany Rusli, Wan-Yu Mao, Pei-Wen Huang, Sin-Ting Wang, Wan-Chen Tsai, Ya-Hsu Chiu, Ting-Hsun Lin, Wan-Ling Chiang, Che-Kai Chang, Zi-Lun Lai, Mei-Chih Chen, Shao-Chih Chiu, Der-Yang Cho

Journal: Advanced Science

PubMed ID: 41632088

Doi: 10.1002/advs.202519440

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Authors: Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue

Journal: Advanced Science

PubMed ID: 41637534

Doi: 10.1002/advs.202505240

Products & Services: Protein Electrophoresis and Western

Engineering New-to-Nature Biological Pathways for β,γ-Alkanediol Synthesis

Authors: Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan

Journal: Advanced Science

PubMed ID: 41677379

Doi: 10.1002/advs.202519742

Human DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation

Authors: Natália C Moreno, Emilie J Korchak, Marcela T Latancia, Dana A D'Orlando, Temidayo Adegbenro, Ryan P Barnes, Irina Bezsonova, Roger Woodgate, Nicholas W Ashton

Journal: Nucleic Acids Research

PubMed ID: 41693564

Doi: 10.1093/nar/gkag098

PolyP inhibits CobB deacetylase triggering a regulatory coupling to prevent DNA replication initiation

Authors: Ewelina Boguszewska, Zuzanna Hirsz, Magdalena Sroka, Katarzyna Bury, Weronika Chmura, Agnieszka Strzałka, Marta Kołodziej, Jolanta Zakrzewska-Czerwińska, Igor Konieczny

Journal: Nucleic Acids Research

PubMed ID: 41728951

Doi: 10.1093/nar/gkag144

Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells

Authors: Huanhuan Feng, Zhixue Li, Hongdao Zhang, Yuli Zheng, Beiying Xu, Yao Zhang, Lin Zou, Ligang Wu

Journal: Nucleic Acids Research

PubMed ID: 41728952

Doi: 10.1093/nar/gkag112