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Safety and Efficacy of Intravenous and Intrathecal Delivery of AAV9-Mediated ARSA in Minipigs

Authors: Aysilu Mullagulova , Alisa Shaimardanova , Valeriya Solovyeva , Yana Mukhamedshina , Daria Chulpanova , Alexander Kostennikov, Shaza Issa, Albert Rizvanov

Journal: Int J Mol Sci .

PubMed ID: 37298156

Doi: 10.3390/ijms24119204

Products & Services: Gene Synthesis

FOSL2 promotes intertumoral infiltration of T cells and increases pathological complete response rates in locally advanced rectal cancer patients

Authors: Kailun Xu, Xiaoyang Yin, Biting Zhou, Xi Zheng, Hao Wang, Jing Chen, Xue Cai, Huanhuan Gao, Xiaoming Xu, Liuhong Wang, Li Shen, Tiannan Guo, Shu Zheng, Baosheng Li, Yingkuan Shao, Jian Wang

Journal: Cancer Letters

PubMed ID: 36997107

Doi: 10.1016/j.canlet.2023.216145

Products & Services: Synthetic Guide RNA

Ionic displacement of Ca by Pb in calmodulin is affected by arrhythmia-associated mutations

Authors: Valerio Marino, Giuditta Dal Cortivo, Daniele Dell'Orco

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 37201768

Doi: 10.1016/j.bbamcr.2023.119490

Products & Services: Codon Optimization

Engineered ketocarotenoid biosynthesis in the polyextremophilic red microalga Cyanidioschyzon merolae 10D

Authors: Mark Seger , Fakhriyya Mammadova , Melany Villegas-Valencia , Barbara ´ Bastos de Freitas , Clarissa Chang , Iona Isachsen , Haley Hemstreet , Fatimah Abualsaud , Malia Boring , Peter J. Lammers , Kyle J. Lauersen

Journal: Metabolic engineering communications

Doi: 10.1016/j.mec.2023.e00226

Products & Services: Gene Synthesis

Mining the UniProtKB /Swiss Prot database for antimicrobial peptides

Authors: Chenkai Li; Darcy Sutherland; Ali Salehi; Amelia Richter; Diana Lin; Sambina Islam Aninta; Hossein Ebrahimikondori; Anat Yanai; Lauren Coombe; Ren L. Warren; Monica Kotkoff; Linda M. N. Hoang; Caren C. Helbing; Inanc Birol

Journal: Protein science : a publication of the Protein Society

PubMed ID: 40100125

Doi: 10.1002/pro.70083

Products & Services: Peptide Synthesis

Simultaneous enhancement of multiple functional properties using evolution-informed protein design

Authors: Benjamin Fram, Ian Truebridge, Yang Su, Adam J Riesselman, John B Ingraham, Alessandro Passera, Eve Napier, Nicole N Thadani, Samuel Lim, Kristen Roberts, Gurleen Kaur, Michael Stiffler, Debora S Marks, Christopher D Bahl, Amir R Khan, Chris Sander, Nicholas P Gauthier

Journal: biorxiv

PubMed ID: 37214973

Doi: 10.1101/2023.05.09.539914

Products & Services: Molecular Biology Reagents

Inflammation Modifies miR-21 Expression Within Neuronal Extracellular Vesicles to Regulate Remyelination Following Spinal Cord Injury

Authors: Tianyu Han, Peiwen Song, Zuomeng Wu, Yunlei Liu, Wang Ying, Cailiang Shen

Journal: Stem Cell Rev Rep

PubMed ID: 37256514

Doi: 10.1007/s12015-023-10560-y

Products & Services: Gene Synthesis

GSK3 phosphorylates and regulates the Green Revolution protein Rht-B1b to reduce plant height in wheat

Authors: Huixue Dong, Danping Li, Ruizhen Yang, Lichao Zhang, Yunwei Zhang, Xu Liu, Xiuying Kong, Jiaqiang Sun

Journal: Plant Cell

PubMed ID: 36945740

Doi: 10.1093/plcell/koad090

Products & Services: Recombinant Proteins

Deep learning models to predict the editing efficiencies and outcomes of diverse base editors

Authors: Nahye Kim, Sungchul Choi, Sungjae Kim, Myungjae Song, Jung Hwa Seo, Seonwoo Min, Jinman Park, Sung-Rae Cho, Hyongbum Henry Kim

Journal: Nat Biotechnol

PubMed ID: 37188916

Doi: 10.1038/s41587-023-01792-x

Products & Services: Gene Synthesis

A highly efficient transgene knock-in technology in clinically relevant cell types

Authors: Alexander G Allen, Samia Q Khan, Carrie M Margulies, Ramya Viswanathan, Swarali Lele, Laura Blaha, Sean N Scott, Kaitlyn M Izzo, Alexandra Gerew, Rithu Pattali, Nadire R Cochran, Carl S Holland, Amy H Zhao, Stephen E Sherman, Michael C Jaskolka, Meng Wu, Aaron C Wilson, Xiaoqi Sun, Dawn M Ciulla, Deric Zhang, Jacqueline D Nelson, Peisheng Zhang, Patrizia Mazzucato, Yan Huang, Georgia Giannoukos, Eugenio Marco, Michael Nehil, John A Follit, Kai-Hsin Chang, Mark S Shearman, Christopher J Wilson, John A Zuris

Journal: Nat Biotechnol

PubMed ID: 37127662

Doi: 10.1038/s41587-023-01779-8

Products & Services: Gene Synthesis