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An additional site mutation in STING/MITA gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy

Authors: Fang-Xu Li, Sheng Liu, Zhi-Dong Zhang, Xin Shuai, Bi-Kun Xiao, Jia Yang, Defen Lu, Dandan Lin, Guijun Shang, Bo Zhong

Journal: Cell Insight

PubMed ID: 41626295

Doi: 10.1016/j.cellin.2026.100298

Products & Services: Peptide Synthesis

Enhancing Enzyme Activity With Mutation Combinations Guided by Few-Shot Learning and Causal Inference

Authors: Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian

Journal: ANGEWANDTE CHEMIE International Edition

PubMed ID: 42329188

Doi: 10.1002/anie.7768514

Products & Services: Protein and Antibody Isolation

Avian Foxp3 acts as a switch for IL-10 by directly binding the T3G motif: revealing a novel epigenetic modulation paradigm

Authors: Tianxu Li, Shouwen Du, Yaxin Wu, Zhouying Chi, Wenjing Yang, Keyi Shi, Zhicheng Liu, Chunhong Zhang, Xian Zou, Mingfei Sun, Jianfeng Zhang, Ming Liao

Journal: Cell Communication and signaling :ccs

PubMed ID: 42351152

Doi: 10.1186/s12964-026-02967-0

Products & Services: Protein Electrophoresis and Western

STAT3 interference-driven nanomodulators reverse lipid metabolism-associated chemoresistance and potentiate metalloimmunotherapy in breast cancer

Authors: Zifan Pei, Yifan Yin, Nailin Yang, Shumin Sun, Nan Jiang, Fangyi Yu, Xiaofen Zhang, Jihu Nie, Youdong Chen, Longxiao Li, Jie Wu, Fei Gong, Minming Chen, Wei Liu, Liang Cheng

Journal: Cell reports. Medicine

PubMed ID: 42242229

Doi: 10.1016/j.xcrm.2026.102844

Products & Services: Protein Electrophoresis and Western

A Redox-Responsive Reversible Photoacoustic Molecular Probe for Visualizing Atherosclerotic Plaque Redox Status in Vivo

Authors: Aiping Chen, Ning Zhang, Fangkun Yang, Rui Chen, Jinhui Shang, Ge Zhang, Xiaoqi Shao, Yuan Ma, Guosheng Song, Wenming He

Journal: Science china chemistry

Doi: 10.1007/s11426-026-3629-x

Products & Services: Peptide Synthesis

Cholesterol analogs modulate lipid nanoparticle performance for mRNA delivery after lyophilization and enable ocular disease therapy

Authors: Ting Wang, Wanqi Li, Jianyang Chen, Sitian Cheng, Min Gao, Chengyu Jiang, Chengyu Jiang, Bingyi Hu, Tzu-Cheng Sung, Akon Higuchi

Journal: Materials Today Bio

Doi: 10.1016/j.mtbio.2026.103044

Products & Services: Custom mRNA synthesis

Genome-Wide Identification, Characterization, and Functional Analysis of the GSK3/Shaggy-like Gene Family in Melon (Cucumis melo L.)

Authors: Peng Tian, Bing Li, Jingjing Zhang, Xiurui Gao, Wei Liu, Bowen Liu, Zhaowei Li, Jing Yang, Mengyuan Su, Jige Dang, Yanrong Wu

Journal: Horticulturae

Doi: 10.3390

Products & Services: Gene Synthesis

Gut microbiota-modulated glutamic acid rejuvenates the quality of oocytes deteriorated by advanced reproductive age

Authors: Feixue Wang, Wenjun Zeng, Zihao Zhang, Na Li, Zhaokang Cui, Jie Bai, Jiner Yan, Yu Zhang, Yilong Miao, Ling Gu, Bo Xiong

Journal: EMBO Molecular Medicine

PubMed ID: 42103932

Doi: 10.1038/s44321-026-00443-3

Products & Services: Protein Electrophoresis and Western

Diverse binding poses of agonistic neurotoxins on human Nav 1.6

Authors: Xiao Fan, Jian Huang, Lin Yang, Jiaofeng Chen, Huan Wang, Xiaoshuang Huang, Jinli Geng, Qinglin Wu, Yuzhen Xie, Fangzhou Lu, Qinmeng Guo, Zilin Shen, Xueqin Jin, Nieng Yan

Journal: Nature

Doi: 10.1038/s41586-026-10661-x

Machine Learning-Enhanced Ultrasensitive Immuno-CRISPR Array Facilitates Early Diagnosis of Alzheimer’s Disease by Detecting Multiple Plasma Biomarkers

Authors: Liding Zhang, Changwen Yang, Qian Yao, Xuewei Du, Shuai Ding, Yaoqiang Shi, Can Sheng, Ming Wang, Ying Han, Haiming Luo

Journal: Advanced Science

PubMed ID: 42261770

Doi: 10.1002/advs.75983

Products & Services: Catalog Antibodies