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Taming immune responses to AAV gene therapy by programmed in vivo Treg expansion

Authors: Lavesh Gwalani, Mincheol Park, Alexandra B Ysasi, Mona Motwani, Robert Jackson, Jie Bu, Zhengyu Luo, John Bladon, Edith L Pfister, Christian Mueller, Sourav R Choudhury

Journal: Molecular Therapy

PubMed ID: 41691369

Doi: 10.1016/j.ymthe.2026.02.019

Products & Services: Peptide Library Services

Personalized structural biology reveals the molecular mechanisms underlying heterogeneous epileptic phenotypes caused by de novo KCNC2 variants

Authors: Souhrid Mukherjee; Thomas A. Cassini; Ningning Hu; Tao Yang; Bian Li; Wangzhen Shen; Christopher W. Moth; David C. Rinker; Jonathan H. Sheehan; Joy D. Cogan; John H. Newman; Rizwan Hamid; Robert L. Macdonald; Dan M. Roden; Jens Meiler; Georg Kuenze; John A. Phillips; John A. Capra

Journal: Human Genetics and Genomics Advances

PubMed ID: 36035247

Doi: 10.1016/j.xhgg.2022.100131

Products & Services: Custom Vector Construction

In-silico and in-vitro study of novel antimicrobial peptide AM1 from Aegle marmelos against drug-resistant Staphylococcus aureus

Authors: Rudra Awdhesh Kumar Mishra; Gothandam Kodiveri Muthukaliannan

Journal: Scientific REPORTS

PubMed ID: 39468175

Doi: 10.1038/s41598-024-76553-0

Products & Services: Peptide Synthesis

Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity

Authors: Jianan Li, Huilan Liu, Qile Guo, Yiying Zhang, Jiaxin Li, Tian Diao, Liangtao Zheng, Zenghua Deng, Yu Yang, Xueyan Chen, Shishang Qin, Jinhu Li, Yao He, Wanzhuo He, Dongfang Liu, Yufei Bo, Chang Liu, Huinan Lu, Hongtao Fan, Xueda Hu, Jirun Peng, Linnan Zhu, Jianzhong Jeff Xi, Dongfang Wang, Zemin Zhang

Journal: cancer cell

PubMed ID: 41544628

Doi: 10.1016/j.ccell.2025.12.018.

In-silico and in-vitro study of novel antimicrobial peptide AM1 from Aegle marmelos against drug-resistant Staphylococcus aureus

Authors: Rudra Awdhesh Kumar Mishra; Gothandam Kodiveri Muthukaliannan

Journal: Scientific REPORTS

PubMed ID: 39468175

Doi: 10.1038/s41598-024-76553-0

Products & Services: Peptide Synthesis

From Field Overexpression to Biochemical Function: PxCYP6B4 Mediated Hydroxylation Confers Pyrethroid Resistance in Plutella xylostella

Authors: Zhuoda Liu, Yifei Zhou, Dongliang Wang, Ruichi Li, Zhen Tian, Yifan Li, Jiyuan Liu

Journal: Journal of Agricultural and Food Chemistry

PubMed ID: 41645610

Doi: 10.1021/acs.jafc.6c00843

Products & Services: Gene Synthesis Codon Optimization

Protein delivery to the eye: assessing therapeutic potential across inner and outer retina

Authors: Giuditta Dal Cortivo, Carmen Longo, Brigitte Müller, Anna Avesani, Raffaella Pacchiana, Maria Weller, Valerio Marino, Lyubomyr Lytvynchuk, Knut Stieger, Daniele Dell'Orco

Journal: International journal of pharmaceutics

PubMed ID: 41500346

Doi: doi.org/10.1016/j.ijpharm.2026.126568

Products & Services: PCR Cloning and Subcloning

Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading

Authors: Yu Yan, Xuesong Wang, Zhenfei Xie, Daniel L V Bader, Ryan H Lim, Krystal M Ma, Christopher A Cottrell, Jon M Steichen, Liling Xu, Paula M Villavicencio, Madhav Akauliya, Ja-Hyun Koo, Jacqueline Ming Shen, Alexandra Vernich, Oleksandr Kalyuzhniy, Joel D Allen, Ali A Albowaidey, Anthony Alicea, Bingxian Chen, Erik Georgeson, Jordan Renae Ellis-Pugh, Nushin Alavi, Abigail Esposito, Hannah Naili, Nicole Phelps, Brendon Kelley, Michael Kubitz, Quynh Anh Phan, Alessia Liguori, Thavaleak Prum, Ryan Tingle, Danny Lu, Saman Eskandarzadeh, Xiaotie Liu, John E Warner, Stephanie R Weldon, Sunny Himansu, Max Crispin, Usha Nair, Sophia Liu, William R Schief, Facundo D Batista

Journal: Immunity

PubMed ID: 41690309

Doi: 10.1016/j.immuni.2026.01.011

Selective Targeting of Immune Checkpoints HLA-G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Authors: Lisa J Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer

Journal: Advanced Science

PubMed ID: 41662489

Doi: 10.1002/advs.202521448

Attenuation of Influenza a Virus into Live Vaccines Through C-End Degrons

Authors: Ping Wang, Le Li, Yunfang Chen, Le Tong, Zhen Li, Rong Yu, Quan Shen, Qikai Wang, Jihuan Hou, Qisi Zhang, Xu Si, Ning Wang, Demin Zhou, Wen-Xia Tian, Longlong Si

Journal: Advanced Science

PubMed ID: 41721587

Doi: 10.1002/advs.202509425

Products & Services: Peptide Synthesis