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Dual-receptor targeting of type I dendritic cells with DNA-scaffolded nanoparticles enhances STING-licensed antitumor immunity

Authors: Deblin Jana, Emilia Herdes, Justin Moustouka, Kayla M Mash, Jingge Chen, Kareem Ebeid, Marwa Sallam, Akram Abbasi, Tejal Desai

Journal: SCIENCE ADVANCES

PubMed ID: 41481710

Doi: 10.1126/sciadv.aeb0452

Products & Services: Protein and Antibody Isolation

Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance

Authors: Amar Singh, Adam Herman, Devanjan Dey, Samuel Menge, Shilpi Singh, Anna Tran, Anders Matson, Ahmed Mourad, Parthasarathy Rangarajan, Ravi Masuria, Naoya Sato, Sarah Vadnais, Joseph Sushil Rao, Gatikrushna Singh, Melanie L Graham, Sabarinathan Ramachandran, Bernhard J Hering

Journal: SCIENCE ADVANCES

PubMed ID: 41499508

Doi: 10.1126/sciadv.aea0567

Products & Services: Peptide Synthesis

On-demand cancer immunotherapy via single-cell encapsulation of synthetic circuit–engineered cells

Authors: Yue Zhao, Rui Li, Yirui Han, Chaochen Shi, Kyubae Lee, Guangjun Nie, Yazhou Chen

Journal: SCIENCE ADVANCES

PubMed ID: 41533781

Doi: 10.1126/sciadv.aea3573

Products & Services: Monoclonal Antibody Services

Cell surface engineering with a pseudofibrotic ECM reprograms the antifibrotic activity of mesenchymal stromal cells

Authors: Xianghua Zhong, Xinchao Liu, Jiajia Luo, Xinyang Liu, Xueting Wei, Xi Peng, Lu Wang, Huaimin Wang, Kunyu Zhang, Liming Bian, Peng Shi

Journal: SCIENCE ADVANCES

PubMed ID: 41544160

Doi: 10.1126/sciadv.aea0998

Products & Services: Gene Synthesis

Enhanced SfaTnpB enables single-base-specific, one-pot nucleic acid detection for high-sensitivity diagnostics

Authors: Bingrong Xu, Sheng Li, Yong Li, Shuhong Zhao, Xinyun Li, Jianlin Han, Di Wu, Shuaicheng Li, Ling Chen, Shengsong Xie, Xiaosong Han, Changzhi Zhao

Journal: Nucleic Acids Research

PubMed ID: 41505099

Doi: 10.1093/nar/gkaf1433

Products & Services: Codon Optimization

Bringing the ends together: cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis

Authors: Joydeep Baral, Ching-Seng Ang, Paul James McMillan, Kalyan Shobhana, Ayushi Saini, Elizabeth Hinde, Amit Kumar Das, Isabelle Rouiller

Journal: Nucleic Acids Research

PubMed ID: 41521670

Doi: 10.1093/nar/gkaf1418

Products & Services: PCR Cloning and Subcloning

G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails

Authors: Harrison A Fuchs, Yunhui Peng, Shine Ayyapan, Ruben Rosas, Houfang Zhang, Anna R Panchenko, Catherine A Musselman

Journal: Nucleic Acids Research

PubMed ID: 41533587

Doi: 10.1093/nar/gkaf1381

Products & Services: Mutagenesis Services

Multilayered regulation by RNA thermometers enables precise control of Cas9 expression in E. coli

Authors: Elise K Kammerdiener, Sarah K Garcia, Margaret K Bales, Dawn M Klingeman, Adam M Guss, Richard J Giannone, Robert L Hettich, Carrie A Eckert, William G Alexander

Journal: Nucleic Acids Research

PubMed ID: 41533573

Doi: 10.1093/nar/gkaf1495

Products & Services: Mutant Libraries

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR-Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Authors: Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo

Journal: Advanced Science

PubMed ID: 41560288

Doi: 10.1002/advs.202514140

Products & Services: Protein Electrophoresis and Western

Reversible phase dynamics of PsAF5 regulate mitophagy to balance redox levels in Phytophthora sojae

Authors: Jinzhu Chen, Wenhao Li, Qin Peng, Hongwei Zhu, Tan Dai, Jianqiang Miao, Xili Liu