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Mimicry of molecular glues using dual covalent chimeras

Authors: Eden Kapcan, Karolina Krygier, Maya da Luz, Nickolas J Serniuck, Ali Zhang, Jonathan Bramson, Anthony F Rullo

Journal: Nature Communications

PubMed ID: 40128528

Doi: 10.1038/s41467-025-58083-z

Products & Services: Antibody Services

Conformational reorganization and phase separation drive hyper-editing of ADR-2-ADBP-1 complex

Authors: Jianqiang Mu, Cang Wu, Kaiming Xu, Xingang Liu, Yajuan Fu, Zhen Zhang, Jingwei Yu, Chenyang Xue, Zi Wang, Xinmeng Chen, Yanhong Chen, Guangshuo Ou, Zhongmin Liu

Journal: Nucleic Acids Res

PubMed ID: 40037706

Doi: 10.1093/nar/gkaf148

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair

Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris

Journal: Mol Cell

PubMed ID: 40054443

Doi: 10.1016/j.molcel.2025.02.004

Products & Services: Gene Synthesis Mutagenesis Services PCR Cloning and Subcloning Peptide Synthesis

The OsIAA3-OsARF16-OsBUL1 auxin signaling module regulates grain size in rice

Authors: Fengjun Xian, Shuya Liu, Jishuai Huang, Bin Xie, Lin Zhu, Qiannan Zhang, Chen Lv, Yimeng Xu, Xinrong Zhang, Jun Hu

Journal: Plant Physiol

PubMed ID: 40156155

Doi: 10.1093/plphys/kiaf122

Products & Services: Custom DNA/RNA Oligos

Potential role of TRAF2 in pulmonary hypertension in broiler chickens and preparation and specificity analysis of its polyclonal antibody

Authors: Wen Peng, Gen Wan, Sufang Cheng, Guyue Li, Liling Liu, Juan Chen, Pei Liu, Xiaoquan Guo, Xiaona Gao, Gaofeng Cai, Zhanhong Zheng, Ping Liu

Journal: Int J Biol Macromol

PubMed ID: 39798767

Doi: doi.org/10.1016/j.ijbiomac.2025.139741

Products & Services: Protein Electrophoresis and Western

ER nests are specialized ER subdomains in Arabidopsis where peroxisomes and lipid droplets form

Authors: Zachary J Wright , Nathan E Tharp , Bonnie Bartel

Journal: Developmental Cell

Doi: 10.1016/j.devcel.2025.03.005

Products & Services: Gene Synthesis Protein Electrophoresis and Western

Active- and Allosteric-Site Cyclic Peptide Inhibitors of Secreted M. tuberculosis Chorismate Mutase

Authors: Renier H P van Neer, Patricia K Dranchak, Mahesh Aitha, Lijun Liu, Emma K Carlson, Isabella E Jacobsen, Kevin Battaile, Yuhong Fang, Dingyin Tao, Ganesha Rai, Janak Padia, Scott Lovell, Hiroaki Suga, James Inglese

Journal: ACS Infectious Diseases

PubMed ID: 39903128

Doi: 10.1021/acsinfecdis.4c00798

Products & Services: Peptide Synthesis Plasmid DNA Preparation

Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists

Authors: Xiaohong Sang, Haizhan Jiao, Qian Meng, Xiong Fang, Qi Pan, Jiao Zhou, Tingli Qian, Wanqin Zhang, Yan Xu, Jing An, Ziwei Huang, Hongli Hu

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 40063796

Doi: 10.1073/pnas.2425795122

Products & Services: Gene Synthesis

Large Library Docking for Polypharmacology

Authors: Yujin Wu; Seth Vigneron; Joao Braz; Karthik Srinivasan; Elissa A. Fink; Xi-Ping Huang; Xinyu Xu; Harald Huebner; Joseph Y. Kim; Jing Wang; Tara Pfeiffer; Kensuke Sakamoto; Dmytro S. Radchenko; Ramona M. Rodriguiz; Yurii S. Moroz; John J. Irwin; Peter Gmeiner; Christian Billesboelle; Bryan L. Roth; Allan I. Basbaum; Aashish Manglik; William C. Wetsel; Brian K. Shoichet

Journal: Journal of Medicinal Chemistry

PubMed ID: 41712624

Doi: 10.1021/acs.jmedchem.5c03810

Products & Services: Peptide Synthesis

Large Library Docking for Polypharmacology

Journal: Journal of Medicinal Chemistry

PubMed ID: 41712624

Doi: 10.1021/acs.jmedchem.5c03810

Products & Services: Peptide Synthesis