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An AI-derived peptide PCa2 suppresses pancreatic cancer growth via modulation of the ErbB/PI3K/AKT/mTOR/MYC signaling axis

Authors: Weimin Zuo; Siyuan Luo; Haixin Qin; Koon Ho Wong; Shirley W. I. Siu; Alexandre K. Tashima; Yehuda G. Assaraf; Hang Fai Kwok

Journal: Cell Communication and Signaling : CCS

PubMed ID: 41957678

Doi: 10.1186/s12964-026-02856-6

Products & Services: Peptide Synthesis

A D-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis

Authors: Michael J. Pepi; Shibin Chacko; Gary M. Marqus; Vinayak Singh; Zhe Wang; Kyle Planck; Ryan T. Cullinane; Penchala N. Meka; Deviprasad R. Gollapalli; Thomas R. Ioerger; Kyu Y. Rhee; Gregory D. Cuny; Helena I.M. Boshoff; Lizbeth Hedstrom

Journal: ACS Infectious Diseases

PubMed ID: 35015509

Doi: 10.1021/acsinfecdis.1c00461

Guidelines in the Preparation of Fully Synthetic, Human Single-Domain Antibody Phage Display Libraries

Authors: Mark A. Tornetta; Brian P. Whitaker; Olivia M. Cantwell; Peter N. Haytko; Eileen D. Pisors; Fulai Zhou; Mark L. Chiu

Journal: Antibodies

PubMed ID: 40843683

Doi: 10.3390/antib14030071

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria

Authors: Hannah E. Snoke; Stephanie M. Reeve; Suresh Dharuman; Miranda J. Wallace; Victoria C. Loudon; Ying Zhao; John J. Bowling; Patricia A. Murphy; Brett Waddell; Robin B. Lee; J rgen B. Bulitta; Richard E. Lee

Journal: ACS Infectious Diseases

PubMed ID: 41116192

Doi: 10.1021/acsinfecdis.5c00635

T cell cholesterol transport links intestinal immune responses to dietary lipid absorption

Authors: Yajing Gao, John P Kennelly, Xu Xiao, Emily Whang, Alessandra Ferrari, Alexander H Bedard, Julia J Mack, Alexander Nguyen, Sonal Srikanth, Thomas Weston, Lauren F Uchiyama, Whitaker Cohn, Danielle H Cho, Min Sub Lee, Julian Whitelegge, Yousang Gwack, Stephen G Young, Steven J Bensinger, Peter Tontonoz

Journal: Science

PubMed ID: 41066556

Doi: 10.1126/science.adt4169

Products & Services: Recombinant Proteins

A human-specific regulatory mechanism revealed in a pre-implantation model

Authors: Raquel Fueyo, Sicong Wang, Olivia J. Crocker, Tomek Swigut, Hiromitsu Nakauchi & Joanna Wysocka

Journal: Nature

PubMed ID: 41034587

Doi: 10.1038/s41586-025-09571-1

DLFea4AMPGen de novo design of antimicrobial peptides by integrating features learned from deep learning models

Authors: Han Gao, Feifei Guan, Boyu Luo, Dongdong Zhang, Wei Liu, Yuying Shen, Lingxi Fan, Guoshun Xu, Yuan Wang, Tao Tu, Ningfeng Wu, Bin Yao, Huiying Luo, Yue Teng, Jian Tian, Huoqing Huang

Journal: Nature Communications

PubMed ID: 41093853

Doi: 10.1038/s41467-025-64378-y

Virus-inspired lipopeptide-derived nucleic acid delivery to cartilage for osteoarthritis therapy

Authors: Yu Fu, Yulan Huang, Yunjiao Wang, Zhenlan Fu, Wenyun Cai, Lu Wang, Yuchun Wu, Xing Zhou, Zhongyi Ma, Zhigang Xu, Yaqin Tang, Jing Xie, Jiayun Jiang, Robert J. Lee & Chong Li

Journal: Nature Communications

PubMed ID: 41102140

Doi: 10.1038/s41467-025-64212-5

DNA StairLoop: enabling high-fidelity data recovery and robust error correction in DNA-based data storage

Authors: Zihui Yan, Guanjin Qu, Xin Chen, Gang Zheng & Huaming Wu

Journal: Nature Communications

PubMed ID: 41102205

Doi: 10.1038/s41467-025-64230-3

The nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection

Authors: Tai-Ting Woo, Yuka Takeo, Mara C Harwood, Ethan T Houck, Daniel DiMaio, Billy Tsai

Journal: SCIENCE ADVANCES

PubMed ID: 41124246

Doi: 10.1126/sciadv.adz6792