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Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation

Authors: Gang Shen, Zhenzhen Fang, Fuyan Hong, Mian Wu, Jing Zhang, Jinhong Wang, Chuan Bai, Wencan Chen, Xia Yang, Chunhua Deng, Haibing Chen, Guoquan Gao, Ti Zhou

Journal: Communications Biology

PubMed ID: 40783594

Doi: 10.1038/s42003-025-08607-6.

Products & Services: Protein and Antibody Isolation

Laodelphax striatellus salivary sheath protein Lsactin triggers defense response in plants

Authors: Liangxuan Qi, Jing Li, Han Wang, Jing Li, Xinyang Tan, Zhichang Zhao, Sicong Zhou, Jichao Fang, Rui Ji

Journal: Insect biochemistry and molecular biology

PubMed ID: 40543628

Doi: 10.1016/j.ibmb.2025.104351

Products & Services: Polyclonal Antibody Services

Sonodynamic therapy augmented by glycolysis inhibition: a novel metabolic reprogramming strategy for enhanced osteosarcoma treatment

Authors: Zhuorun Song, Shunyi Lu, Yuqi Yang, Zijun Chen, Youdong Chen, Jie Cao, Zimin Zhang, Jun Ge, Huilin Yang, Liang Cheng

Journal: National Science Review

Doi: 10.1093/nsr/nwaf365

Products & Services: Protein and Antibody Isolation

A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo

Authors: Wei Zhang, Lizhen Yuan, Rui Liu, Yanbo Jing, Shijun Lin, Hao Fang, Yuxuan Li, Xiaohui Zhang, Jun Dai, Tao Liu, Fan Xia, Xiaoding Lou

Journal: J Am Chem Soc

PubMed ID: 40717291

Doi: 10.1021/jacs.5c07041

Products & Services: Recombinant Proteins

Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain

Authors: Thales Hein Da Rosa, Sterling H Ramsey, Judy J Lee, Natalia Y Kozlova, Zixuan Zhao, Jaeyeon Kim, Ava C Schneider, Sheng Li, Madhusudhanarao Katiki, Gary S Firestein, Ramachandran Murali, Eugenio Santelli, Stephanie M Stanford, Nunzio Bottini

Journal: The Journal of Biological Chemistry

PubMed ID: 40651610

Doi: 10.1016/j.jbc.2025.110470

Products & Services: Mutagenesis Services PCR Cloning and Subcloning Gene Synthesis

Epitope molecularly imprinted polymers based on host-guest interaction: specific recognition of CD59

Authors: Yitong Xu, Huifeng Zhang, Ying Zhang, Jiutong Ma, Qiong Jia

Journal: Journal of chromatography. A

PubMed ID: 40382882

Doi: doi.org/10.1016/j.chroma.2025.466056

Products & Services: Peptide Synthesis

Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids

Authors: Kirsten Broderick, Mohamed Taha Moutaoufik, Tatiana Saccon, Ramy Malty, Shahreen Amin, Sadhna Phanse, Thomson Patrick Joseph, Mara Zilocchi, Ali Hosseinnia, Zoe Istace, Maryam Hajikarimlou, Sakib Abrar, Jade Fisher, Raelynn Brassard, Ranawaka Perera, Anil Kumar, Hiroyuki Aoki, Matineh Rahmatbakhsh, Matthew Jessulat, Darwyn Kobasa, Frank Dehne, Bhanu Prasad, Alla Gagarinova, M Joanne Lemieux, Alan Cochrane, Walid A Houry, Khaled A Aly, Ashkan Golshani, Mohan Babu

Journal: Nature Communications

PubMed ID: 40593736

Doi: 10.1038/s41467-025-60949-1

Products & Services: Gene Synthesis

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity

Authors: Victoria Gonzalez, Briallen Lobb, Jacob Côté, Arkadeb Bhuinya, Adriana G Tubb, Stephen S Nuthalapati, Akarin Asavajaru, Yan Zhou, Vikram Misra, Darryl Falzarano, Trevor R Sweeney, Sophie M C Gobeil, Linfa Wang, Andrew C Doxey, Arinjay Banerjee

Journal: Nature Communications

PubMed ID: 40593754

Doi: 10.1038/s41467-025-61254-7

Products & Services: PCR Cloning and Subcloning

CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage

Authors: Justin Van Riper, Arleth O Martinez-Claros, Lie Wang, Hannah E Schneiderman, Sweta Maheshwari, Monica C Pillon

Journal: Nature Communications

PubMed ID: 40592880

Doi: 10.1038/s41467-025-61091-8

Products & Services: Gene Synthesis

The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress

Authors: Qianqian Dong, Matthew Day, Yuichiro Saito, Emma Parker, Lotte P Watts, Masato T Kanemaki, Antony W Oliver, Laurence H Pearl, Shin-Ichiro Hiraga, Anne D Donaldson

Journal: Nature Communications

PubMed ID: 40595496

Doi: 10.1038/s41467-025-60817-y

Products & Services: Custom Vector Construction