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Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies

Authors: Julia Lederhofer, Andrew J Borst, Lam Nguyen, Rebecca A Gillespie, Connor J Williams, Emma L Walker, Julie E Raab, Christina Yap, Daniel Ellis, Adrian Creanga, Hyon-Xhi Tan, Thi H T Do, Michelle Ravichandran, Adrian B McDermott, Valerie Le Sage, Sarah F Andrews, Barney S Graham, Adam K Wheatley, Douglas S Reed, Neil P King, Masaru Kanekiyo

Journal: Nature Communications

PubMed ID: 40750617

Doi: 10.1038/s41467-025-62339-z.

Products & Services: Custom Vector Construction

Identification of distinct epitopes in dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid

Authors: Shoko Mai https://orcid.org/0000-0001-5468-6851, Yosuke Mai https://orcid.org/0000-0001-6356-7192, Inkin Ujiie https://orcid.org/0000-0002-7931-949X, Kentaro Izumi https://orcid.org/0000-0001-8221-9644, Ken Natsuga https://orcid.org/0000-0003-3865-6366, Wataru Nishie https://orcid.org/0000-0002-0486-9112, and Hideyuki Ujiie

Journal: SCIENCE ADVANCES

PubMed ID: 40749047

Doi: 10.1126/sciadv.adv9423

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An Apple Susceptibility-Related LRR Receptor-Like Kinase MdRLKT21 Activates Plant Immunity by Hijacking a Trans-Kingdom Fungal microRNA-Like RNA

Authors: Mingliang Lei, Jian Zhang, Jie Wang, Chengyu Gao, Yanting He, Runze Tian, Hao Feng, Lili Huang

Journal: Advanced Science

PubMed ID: 40755370

Doi: 10.1002/advs.202417426

A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies

Authors: Jessey Erath, Danielle Kemper, Elisha Mugo, Alex Jacoby, Elizabeth Valenzuela, Courtney F Jungers, Wandy L Beatty, Yaser Hashem, Marko Jovanovic, Sergej Djuranovic, Slavica Pavlovic Djuranovic

Journal: Nature Communications

PubMed ID: 40764614

Doi: 10.1038/s41467-025-62314-8.

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14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state

Authors: Juliana A Martinez Fiesco, Alexandra Beilina, Astrid Alvarez de la Cruz, Ning Li, Riley D Metcalfe, Mark R Cookson, Ping Zhang

Journal: Nature Communications

PubMed ID: 40764514

Doi: 10.1038/s41467-025-62337-1.

Products & Services: Codon Optimization

Structural basis of fast N-type inactivation in Kv channels

Authors: Xiao-Feng Tan, Ana I Fernández-Mariño, Yan Li, Tsg-Hui Chang, Kenton J Swartz

Journal: Nature

PubMed ID: 40770100

Doi: 10.1038/s41586-025-09339-7

Products & Services: Peptide Synthesis

Lipid interactions and gating hysteresis suggest a physiological role for mechanosensitive channel YnaI

Authors: Nathan Will, Giorgos Hiotis, Yoshitaka Nakayama, Gabriella Angiulli, Zijing Zhou, Charles D Cox, Boris Martinac, Thomas Walz

Journal: Nature Communications

PubMed ID: 40796571

Doi: 10.1038/s41467-025-62805-8.

Products & Services: PCR Cloning and Subcloning

High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants

Authors: Mihkel Örd, Matthew J Winters, Mythili S Subbanna, Natàlia de Martín Garrido, Victoria I Cushing, Johanna Kliche, Caroline Benz, Ylva Ivarsson, Basil J Greber, Peter M Pryciak, Norman E Davey

Journal: Nature Communications

PubMed ID: 40817109

Doi: 10.1038/s41467-025-62765-z.

Products & Services: Peptide Synthesis

POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?

Authors: Hang Liu, Xinyue Li, Mengyi Li, Ziyang Sun, Xu Wang, Juehong Li, Binbin Xu, Qian Chen, Cunyi Fan, Hongjiang Ruan

Journal: Advanced Science

PubMed ID: 40823759

Doi: 10.1002/advs.202507951

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HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates

Authors: Krystal M Ma, Henry J Sutton, Payal P Pratap, Jon M Steichen, Diane Carnathan, James Quinn, Oleksandr Kalyuzhniy, Alessia Liguori, Sashank Agrawal, Sabyasachi Baboo, Patrick Madden, Christopher A Cottrell, Jordan R Willis, Jeong-Hyun Lee, Elise Landais, Xiaozhen Hu, Parham Ramezani-Rad, Gabriel Ozorowski, Vanessa R Lewis, Jolene K Diedrich, Xiaoya Zhou, Tasha K Altheide, Nicole Phelps, Erik Georgeson, Nushin B Alavi, Danny Lu, Saman Eskandarzadeh, Michael Kubitz, Yumiko Adachi, Tina-Marie Mullen, Murillo Silva, Mariane B Melo, Sunny Himansu, Darrell J Irvine, Dennis R Burton, John R Yates 3rd, James C Paulson, Devin Sok, Ian A Wilson, Guido Silvestri, Andrew B Ward, Shane

Journal: Science immunology

PubMed ID: 40845127

Doi: 10.1126/sciimmunol.adt6660

Products & Services: Recombinant Antibody Expression