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A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes

Authors: Enzo Mameli, George-Rafael Samantsidis, Raghuvir Viswanatha, Hyeogsun Kwon, David R Hall, Matthew Butnaru, Yanhui Hu, Stephanie E Mohr, Norbert Perrimon, Ryan C Smith

Journal: Nature Communications

PubMed ID: 41285753

Doi: 10.1038/s41467-025-65304-y.

Products & Services: PCR Cloning and Subcloning

Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins

Authors: Wenjian Han, Bo Yuan, Xiaojuan Fan, Weike Li, Yiting Yuan, Yuefang Zhang, Shu Wang, Shifang Shan, Markus Hafner, Zefeng Wang, Zilong Qiu

Journal: Nature Communications

PubMed ID: 41188225

Doi: 10.1038/s41467-025-64748-6.

Products & Services: Gene Synthesis

Structural snapshots capture nucleotide release at the μ-opioid receptor

Authors: Saif Khan, Aaliyah S Tyson, Mohsen Ranjbar, Zixin Zhang, Jaskaran Singh, Gye Won Han, Cornelius Gati

Journal: Nature

PubMed ID: 41193810

Doi: 10.1038/s41586-025-09677-6.

Products & Services: Catalog Peptides

Engineered CXCR3-A expression enhances B7-H3-targeting CAR T cell migration and efficacy against diffuse intrinsic pontine glioma

Authors: Edward Z Song, Andrea Timpanaro, Michael Meechan, Leonel Elena-Sanchez, Lucy Z Li, Sophie Jamet, Davina S Lau, Lily I Winter, Matthew D Dun, Jessica B Foster, Myron K Evans, Siobhan S Pattwell, Vandana Kalia, Surojit Sarkar, Michael C Jensen, Matthew C Biery, Nicholas A Vitanza

Journal: Nature Communications

PubMed ID: 41219209

Doi: 10.1038/s41467-025-64861-6.

Products & Services: Protein and Antibody Isolation

Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma

Authors: Martina Mang Leng Lei, Carmen Oi Ning Leung, Rainbow Wing Hei Leung, Xue Qian Wu, Katherine Po Sin Chung, Catherine Yu Jia Gu, Mandy Sze Man Chan, Wing Ki Chau, Quan Hua Mu, Kai Yu Ng, Man Tong, Jing Ping Yun, Jia Ming Nickolas Teo, Guang Sheng Ling, Patrick Pak Chun Wong, Stephen Lam Chan, Zhe Wen Xiong, Alfred Sze Lok Cheng, Jin Ding, Stephanie Ma, Terence Kin Wah Lee

Journal: Nature Communications

PubMed ID: 41219194

Doi: 10.1038/s41467-025-64860-7.

Products & Services: Mutagenesis Services

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency

Authors: Vinod Tiwari, Byungchang Jin, Olivia Sun, Edwin D J Lopez Gonzalez, Min-Hsuan Chen, Xiwei Wu, Hardik Shah, Andrew Zhang, Mark A Herman, Cassandra N Spracklen, Russell P Goodman, Charles Brenner

Journal: Nature metabolism

PubMed ID: 41238906

Doi: 10.1038/s42255-025-01399-3.

Control of Mycobacterium tuberculosis protein secretion by ESX-4 and the outer membrane EsxUT-EsxEF complex

Authors: Rashmi Ravindran Nair, Virginia Meikle, Swati Dubey, Mikhail Pavlenok, Anna D Tischler, Michael Niederweis

Journal: Nature Communications

PubMed ID: 41266320

Doi: 10.1038/s41467-025-65061-y.

Products & Services: Polyclonal Antibody Services

Interpretable molecular decision-making with DNA-based scalable and memory-efficient tree computation

Authors: Junlan Liu, Qian Tang, Yongqi Han, Jinxing Song, Fei Wang, Pei Guo, Chunhai Fan, Weihong Tan, Da Han

Journal: Nature Communications

PubMed ID: 41271734

Doi: 10.1038/s41467-025-66610-1.

High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures

Authors: Aira F Cabug, Jeremy Chase Crawford, Hayley A McQuilten, Isabelle J H Foo, Lilith F Allen, Deborah Gebregzabher, Robert C Mettelman, Tanya Novak, Janet Chou, Louise C Rowntree, Ruth R Hagen, Abby J Thomson, Genevieve E Martin, Brad Gilbertson, Michael Nt Souter, Fiona James, Emma Goodall, Simone Rizzetto, Tim Flerlage, Xiaoxiao Jia, Lee-Ann Van de Velde, So Young Chang, Fabio Luciani, Ryan S Thwaites, Jason A Trubiano, Tom C Kotsimbos, Allen C Cheng, Adrienne G Randolph, Paul G Thomas, Jianqing Xu, Zhongfang Wang, Thi H O Nguyen, Brendon Y Chua, Lukasz Kedzierski, Katherine Kedzierska

Journal: Nature Communications

PubMed ID: 41285788

Doi: 10.1038/s41467-025-65262-5.

Products & Services: Peptide Synthesis

Nonexpansive biodegradable matrix promotes blood vessel organoid development for neurovascular repair and functional recovery in ischaemic stroke

Authors: Dongling Xiao, Yue Sun, Guanyuan Yang, Weixi Yan, Meilin Jiang, Zhongliang Qin, Zijun Wang, Yawei Gu, Jingting Zhou, Ju Tan, Gang Li, Yinghao Li, Chuhong Zhu

Journal: Nature biomedical engineering

PubMed ID: 41184604

Doi: 10.1038/s41551-025-01550-1

Products & Services: Peptide Library Services