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Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice

Authors: Haoran An, Yijia Huang, Zhifeng Zhao, Kunpeng Li, Jingjing Meng, Xueting Huang, Xianbin Tian, Hongyu Zhou, Jiamin Wu, Qionghai Dai, Jing-Ren Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 40073120

Doi: 10.1126/sciadv.adq6399

Products & Services: Protein and Antibody Isolation

PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover

Authors: Takashi Ono, Yoshitaka Taketomi, Takayoshi Higashi, Hiroyasu Sato, Chika Mochizuki-Ono, Yuki Nagasaki, Takashi Ueta, Takashi Miyai, Suzumi M Tokuoka, Yoshiya Oda, Yasumasa Nishito, Tomio Ono, Choji Taya, Satoru Arata, Sumiko Watanabe, Tomoyoshi Soga, Tetsuya Hirabayashi, Makoto Aihara, Makoto Murakami

Journal: Nature Communications

PubMed ID: 40082403

Doi: 10.1038/s41467-025-57402-8

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A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

Authors: Diana Romero-Zamora, Samuel Rogers, Ronnie Ren Jie Low, Scott G Page, Blake J E Lane, Shunya Kosaka, Andrew B Robinson, Lucy French, Noa Lamm, Fuyuki Ishikawa, Makoto T Hayashi, Anthony J Cesare

Journal: Nature Communications

PubMed ID: 40097392

Doi: 10.1038/s41467-025-57456-8

Products & Services: Polyclonal Antibody Services

FGF2 Mediated USP42-PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Authors: Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li

Journal: Advanced Science

PubMed ID: 40091484

Doi: 10.1002/advs.202408724

Products & Services: Recombinant Proteins

Orally delivered toxin–binding protein protects against diarrhoea in a murine cholera model

Authors: Marcus Petersson, Franz G Zingl, Everardo Rodriguez-Rodriguez, Jakob K H Rendsvig, Heidi Heinsøe, Emma Wenzel Arendrup, Natalia Mojica, Dario Segura Peña, Nikolina Sekulić, Ute Krengel, Monica L Fernández-Quintero, Timothy P Jenkins, Lone Gram, Matthew K Waldor, Andreas H Laustsen, Sandra Wingaard Thrane

Journal: Nature Communications

PubMed ID: 40108169

Doi: 10.1038/s41467-025-57945-w

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Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining

Authors: Yan Wang, Fuyuan Shen, Chen Zhao, Jiali Li, Wen Wang, Yamu Li, Jia Gan, Haojian Zhang, Xuefeng Chen, Qiang Chen, Fangyu Wang, Ying Liu, Yan Zhou

Journal: Nucleic Acids Res

PubMed ID: 40114375

Doi: 10.1093/nar/gkaf200

Products & Services: Peptide Synthesis

Transport and InsP8 gating mechanisms of the human inorganic phosphate exporter XPR1

Authors: Qinyu Zhu, Madeleine F Yaggi, Nikolaus Jork, Henning J Jessen, Melinda M Diver

Journal: Nature Communications

PubMed ID: 40113814

Doi: 10.1038/s41467-025-58076-y

Products & Services: Protein and Antibody Isolation

Machine Learning-Aided Identification of Fecal Extracellular Vesicle microRNA Signatures for Noninvasive Detection of Colorectal Cancer

Authors: Zhaowei Zhang, Xuyang Liu, Chuanyue Peng, Rui Du, Xiaoqin Hong, Jia Xu, Jiaming Chen, Xiaomin Li, Yujing Tang, Yuwei Li, Yang Liu, Chen Xu, Dingbin Liu

Journal: ACS Nano

PubMed ID: 40033785

Doi: 10.1021/acsnano.4c16698

Products & Services: Synthetic Guide RNA Catalog Gene Editing

GPR132 regulates the function of NK cells through the Gαs/CSK/ZAP70/NF-κB signaling pathway as a potential immune checkpoint

Authors: Xinhui Hui, Min Xue, Yaojun Ren, Yiran Chen, Xuenan Chen, Muhammad Asad Farooq, Yuzhou Ji, Weirong Zhan, Yunhe Huang, Bingtan Du, Jie Yao, Yixin Duan, Wenzheng Jiang

Journal: Sci Adv

PubMed ID: 40043109

Doi: doi/10.1126/sciadv.adr9395

Products & Services: Protein and Antibody Isolation

Manganese-Driven Plasmid Nanofibers Formed In Situ for Cancer Gene Delivery and Metalloimmunotherapy

Authors: Jiexin Li, Ruiqi Yang, Chen Zhang, Jonathan F Lovell, Yumiao Zhang

Journal: J Am Chem Soc

PubMed ID: 40065259

Doi: 10.1021/jacs.4c18511

Products & Services: Recombinant Proteins