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页码: 71/5234 每页显示数量

A novel, covalent broad-spectrum inhibitor targeting human coronavirus Mpro

Authors: Jing Sun, Deheng Sun, Qi Yang, Dong Wang, Jingjing Peng, Hu Guo, Xiaoyu Ding, Zhao Chen, Bin Yuan, Yan A Ivanenkov, Jinwei Yuan, Bogdan A Zagribelnyy, Yiyun He, Jingyi Su, Ling Wang, Jielin Tang, Zhun Li, Rong Li, Taotao Li, Xiaoyu Hu, Xing Liang, Airu Zhu, Peilan Wei, Yaya Fan, Sang Liu, Jie Zheng, Xin Guan, Alex Aliper, Minglei Yang, Dmitry S Bezrukov, Zhanhong Xie, Victor A Terentiev, Guilin Peng, Daniil A Polykovskiy, Alexander S Malyshev, Maxim N Malkov, Qingsong Zhu, Alán Aspuru-Guzik, Xiao Ding, Xin Cai, Man Zhang, Jingxian Zhao, Nanshan Zhong, Feng Ren, Xinwen Chen, Alex Zhavoronkov, Jincun Zhao

Journal: Nature Communications

PubMed ID: 40374668

Doi: 10.1038/s41467-025-59870-4

Products & Services: Peptide Synthesis

Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila

Authors: Sabrina J Fletcher, Eugenia S Bardossy, Lorena Tomé-Poderti, Thomas Moss, Vanesa Mongelli, Lionel Frangeul, Hervé Blanc, Yann Verdier, Joelle Vinh, Shaeri Mukherjee, Maria-Carla Saleh

Journal: SCIENCE ADVANCES

PubMed ID: 40378201

Doi: 10.1126/sciadv.adv1286

Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens

Authors: Sifeng Gu , Zsolt Bodai , Rachel A Anderson , Hei Yu Annika So , Quinn T Cowan , Alexis C Komor

Journal: Nature Communications

PubMed ID: 40394064

Doi: 10.1038/s41467-025-59948-z

Functional divergence of plant SCAR/WAVE proteins is determined by intrinsically disordered regions

Authors: Sabine Brumm, Aleksandr Gavrin, Matthew Macleod, Guillaume Chesneau, Annika Usländer, Sebastian Schornack

Journal: SCIENCE ADVANCES

PubMed ID: 40397725

Doi: 10.1126/sciadv.adt6107

Products & Services: Gene Synthesis

Graphene oxide enhances aphid resistance in sorghum via the miR319-SbTCP7-SbLOX3 Pathway

Authors: Yannan Shi, Zhiyin Jiao, Jinping Wang, Zhifang Wang, Cheng Chu, Yongchao Guo, Peng Lv, Junfeng Cao

Journal: Plant Biotechnology Journal.

PubMed ID: 40397692

Doi: 10.1111/pbi.70132

Products & Services: Gene Synthesis

Expanding the σ54-dependent transcription process with orthogonal designs

Authors: Yiheng Liu, Shuyi Cai, Ziyi Zhang, Zhuoting Xie, Chenyue Guo, Yi-Ping Wang, Jianguo Yang

Journal: Nucleic Acids Research

PubMed ID: 40401558

Doi: 10.1093/nar/gkaf442

Products & Services: Gene Synthesis

Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor

Authors: Yang Wang, Ming Liu, Shan Wang, Xinyi Mai, Xi Wang, Fei Teng, Tianrui Lyu, Ming-Yuan Su, Goran Stjepanovic

Journal: SCIENCE ADVANCES

PubMed ID: 40408472

Doi: 10.1126/sciadv.adu8708

Products & Services: Peptide Synthesis

Multi-level ROS regulation to activate innate and adaptive immune therapies

Authors: Ke-Ke Feng, Cheng-Lei Li, Yi-Fan Tu, Shi-Cheng Tian, Rui Xiong, Bai-Sheng Sa, Jing-Wei Shao

Journal: Chemical Engineering Journal

Doi: doi.org/10.1016/j.cej.2025.163429

Products & Services: Gene Synthesis

LPS-enriched interaction drives spectrum conversion in antimicrobial peptides: Design and optimization of AA16 derivatives for targeting gram-negative bacteria

Authors: Wanyang Xiao, Ruize Sun, Jietao Lou, Yanyan Xu, Xiaokun Li, Kaiyun Xin, Weijie Lu, Chenhui Sun, Tianbao Chen, Yitian Gao, Di Wu

Journal: Eur J Med Chem

PubMed ID: 40048797

Doi: 10.1016/j.ejmech.2025.117462

Products & Services: Peptide Synthesis

Chondrocyte fatty acid oxidation drives osteoarthritis via SOX9 degradation and epigenetic regulation

Authors: Zixuan Mei, Kamuran Yilamu, Weiyu Ni, Panyang Shen, Nan Pan, Huasen Chen, Yingfeng Su, Lei Guo, Qunan Sun, Zhaomei Li, Dongdong Huang, Xiangqian Fang, Shunwu Fan, Haitao Zhang, Shuying Shen

Journal: nature COMMUNICATION

PubMed ID: 40425566

Doi: 10.1038/s41467-025-60037-4

Products & Services: Catalog Antibodies Protein and Antibody Isolation